Serum Anti-carbonic Anhydrase Antibodies and Oxidant–Antioxidant Balance in Patients with Acute Anterior Uveitis

Türk, Adem; Aykut, Murat; Akyol, Nurettin; Kola, Mehmet; Menteşe, Ahmet; Sümer, Ayşegül; Alver, Ahmet; Erdöl, Hidayet

doi:10.3109/09273948.2013.830753

Cited by 23 publications

(20 citation statements)

References 35 publications

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“…These proteins are alpha-1-acid glycoprotein 1 (Gupta et al 1991), recoverin (Whitcup et al 1998;Deeg et al 2008), selenium-binding protein 1 (Okunuki et al 2007), perforin (Young et al 1990;Dix et al 2003) and carbonic anhydrase 1 (Thurau 2005;Turk et al 2014). Elevated concentration of serum alpha-1-acid glycoprotein 1, recoverin and carbonic anhydrase has been reported in acute anterior uveitis and Behcet's disease (Sen et al 1992;Chiu et al 1977;Gupta et al 1991;Whitcup et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Kasudhan¹,

Sarkar²,

Gupta

et al. 2018

Acta Ophthalmologica

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Section: Discussionmentioning

confidence: 99%

Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Kasudhan¹,

Sarkar²,

Gupta

et al. 2018

Acta Ophthalmologica

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“…The presence of CA autoantibodies has been documented in acute anterior uveitis, Graves’ disease, systemic lupus erythematosus, Sjögren’s syndrome, endometriosis, idiopathic chronic pancreatitis, primary biliary cirrhosis, tubulointerstitial nephritis, autoimmune hepatitis, and autoimmune cholangitis. 17,18,19,20,21,24,25,26,27 …”

Section: Discussionmentioning

confidence: 99%

“…17,18,19,20,21 Based on this premise, the aim of our study was to investigate the presence of CA autoantibodies in patients with type 1 diabetes, which is considered an immunological disease, and to examine possible associations between these autoantibodies and DRP.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Serum Carbonic Anhydrase 1-2 Autoantibody Levels and Diabetic Retinopathy in Type 1 Diabetes Patients

Türk

Mollamehmetoğlu

Alver

et al. 2017

tjo

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Objectives:To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes.Materials and Methods:A total of 37 type-1 diabetic patients, 17 with DRP (group 1) and 20 without (group 2), and 38 healthy control subjects (group 3) were included. CA-I and CA-II autoantibody levels were measured in serum samples obtained from each of the three groups and compared statistically. Additionally, the correlation between CA-I and CA-II autoantibody levels and the presence of diabetic macular edema was examined.Results:Mean measured CA-I autoantibody levels were 0.145±0.072, 0.117±0.047, and 0.138±0.061 ABSU in group 1, group 2, and group 3, respectively (p=0.327). The average CA-II autoantibody levels achieved in the same groups were 0.253±0.174, 0.155±0.137, and 0.131±0.085 ABSU, respectively (p=0.005). No significant difference was obtained between the subgroups of group 1, with macular edema (n=8) and without (n=9), in terms of both CA-I and CA-II autoantibody levels (p=0.501, p=0.178, respectively).Conclusion:A significant correlation was observed between the development of DRP and serum CA-II autoantibody levels in type 1 diabetic cases. However, there was no correlation between the autoantibody levels and the presence of diabetic macular edema in cases with DRP.

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“…It is a major cause of severe visual handicap and is responsible for an estimated 10% of all blindness in the United States 14. The etiology of uveitis is complicated and its pathological mechanism is not clear up to date, in which oxidative stress may play an important role 1516. Steroids, cyclosporine A and other immunosuppressors are all effective drugs to treat uveitis; however, long-term use is precluded because of significant side effects, such as osteoporosis and renal toxicity 17.…”

Section: Introductionmentioning

confidence: 99%

Effects of hydrogen-rich saline on endotoxin-induced uveitis

et al. 2017

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The therapeutic effects of hydrogen-rich saline (HRS) have been reported for a wide range of diseases mainly via selectively reducing the amount of reactive oxygen species. Oxidative stress plays an important role in the pathogenesis of uveitis and endotoxin-induced uveitis (EIU). In this study, we investigated whether HRS can mitigate EIU in rats. Sprague-Dawley rats were randomly divided into Norm group, Model group, HRS group, dexamethasone (DEX) group, and rats in the latter three groups were injected with equal amount of lipopolysaccharide (LPS) to induce EIU of different severities (by 1 mg/kg of LPS, or 1/8 mg/kg of LPS). Rats in HRS group were injected with HRS intraperitoneally at three different modes to purse an ameliorating effect of EIU (10 mL/kg of HRS immediately after injection of 1 mg/kg of LPS, 20 mL/kg of HRS once a day for 1 week before injection of 1 mg/kg of LPS and at 0, 0.5, 1, 2, 6, 8, 12 hours after LPS administration, or 20 mL/kg of HRS once a day for 1 week before injection of 1/8 mg/kg of LPS, and at 0, 0.5, 1, 2, 6, 8, 12, 24 hours and once a day for 3 weeks after LPS administration). Rats of DEX group were injected with 1 mL/kg of DEX solution intraperitoneally immediately after LPS administration. Rats in Norm and Model groups did not receive any treatment. All rats were examined under slit lamp microscope and graded according to the clinical signs of uveitis. Electroretinogram, quantitative analysis of protein in aqueous humor (AqH) and histological examination of iris and ciliary body were also carried out. Our results showed that HRS did not obviously ameliorate the signs of uveitis under slit lamp examination and the inflammatory cells infiltration around iris and cilliary body of EIU induced by 1 mg/kg or 1/8 mg/kg of LPS (P > 0.05), while DEX significantly reduced the inflammation reflected by the above two indicators (P < 0.05). The impaired retinal function of mild EIU induced by 1/8 mg/kg of LPS, showed by delay of peak time of b-wave of Dark adapted 3.0 electroretinogram, was not significantly restored by HRS (P > 0.05), while DEX had an obvious therapeutic effect (P < 0.05). However, HRS exerted an inhibition trend on elevation of protein in AqH of EIU induced by 1 mg/kg of LPS, and significantly reduced the increasing amount of protein in AqH of mild EIU induced by 1/8 mg/kg of LPS (P < 0.05). In conclusion, HRS could not obviously mitigate EIU in rats, while it could inhibit the elevation of AqH protein.

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Serum Anti-carbonic Anhydrase Antibodies and Oxidant–Antioxidant Balance in Patients with Acute Anterior Uveitis

Abstract: These results suggest that autoimmune responses against CA I and CA II and an altered serum oxidant-antioxidant balance may be involved in the pathogenesis of AAU.

Cited by 23 publications

References 35 publications

Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

The Relationship between Serum Carbonic Anhydrase 1-2 Autoantibody Levels and Diabetic Retinopathy in Type 1 Diabetes Patients

Effects of hydrogen-rich saline on endotoxin-induced uveitis

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