Serum ANGPTL2 Levels Reflect Clinical Features of Breast Cancer Patients: Implications for the Pathogenesis of Breast Cancer Metastasis

Endo, Motoyoshi; Yamamoto, Yutaka; Nakano, Masahiro; Masuda, Tetsuro; Odagiri, Haruki; Horiguchi, Haruki; Miyata, Keishi; Kadomatsu, Tsuyoshi; Motokawa, Ikuyo; Okada, Seiji; Iwase, Hirotaka; Oike, Yuichi

doi:10.5301/jbm.5000080

Cited by 39 publications

(39 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another interesting feature of our study was the existence of a statistically significant correlation between ANGPTL2 expression in primary lesions and the levels of ANGPTL2 in serum. Recently, Endo and colleagues demonstrated that breast cancer cells secrete ANGPTL2 in vitro and in vivo, and serum ANGPTL2 levels in patients with metastatic breast cancer were significantly higher compared with healthy controls (27). This report supports our hypothesis that serum ANGPTL2 in patients with colorectal cancer is likely secreted by primary colorectal cancer tissues.…”

Section: Discussionsupporting

confidence: 80%

Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

Toiyama

Tanaka

Kitajima

et al. 2014

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Angiopoietin-like protein 2 (ANGPTL2) is a mediator of chronic inflammation and inflammatory carcinogenesis. The biologic and clinical significance of ANGPTL2 remains unknown in human cancer. Therefore, we investigated the function of ANGPTL2 and evaluated its clinical significance in both primary tumors and matched sera in patients with colorectal cancer.Experimental Design: A colorectal cancer cell line was transfected with siRNA against ANGPTL2 for the assessment of its function. We examined ANGPTL2 expression in colorectal cancer tissues (n ¼ 195) by immunohistochemistry. Finally, we screened serum ANGPTL2 levels from 32 colorectal cancers and 23 normal controls (NC), and validated these results in serum samples obtained from 195 colorectal cancers and 45 NCs by ELISA.Results: Knockdown of ANGPTL2 in vitro significantly inhibited cell proliferation, migration, and invasion, whereas it enhanced anoikis. ANGPTL2 was overexpressed in colorectal cancer tissues, and was significantly associated with advanced T stage, lymph node, and liver metastasis. Likewise, serum ANGPTL2 levels in colorectal cancers were significantly higher than NCs (P < 0.01), and allowed distinguishing of colorectal cancers from NCs with high accuracy (AUC ¼ 0.837). The subsequent validation step confirmed that serum ANGPTL2 levels in colorectal cancers were significantly higher than in NCs (P < 0.0001), and had a high AUC value (0.885) for distinguishing colorectal cancers from NCs. High serum ANGPTL2 was significantly associated with advanced T stage, lymph node and liver metastasis, early relapse, and poor prognosis in colorectal cancers.Conclusion: Serum ANGPTL2 is a novel diagnostic and recurrence-predictive biomarker in patients with colorectal cancer. Clin Cancer Res; 20(23); 6175-86. Ó2014 AACR.

show abstract

Section: Discussionsupporting

confidence: 80%

Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

Toiyama

Tanaka

Kitajima

et al. 2014

Clinical Cancer Research

View full text Add to dashboard Cite

show abstract

“…Figure 3B). More recently, it was reported that serum ANGPTL2 levels in patients with metastatic breast cancer are significantly higher than those in healthy individuals or in patients with ductal carcinoma in situ or non-metastatic invasive ductal carcinoma [48]. This finding raises a possibility that serum ANGPTL2 levels in breast cancer patients could be a potential marker of breast cancer metastasis.…”

Section: Roles Of Angptl2 In Carcinogenesis and Metastasismentioning

confidence: 98%

Diverse roles of ANGPTL2 in physiology and pathophysiology

Kadomatsu¹,

Endo²,

Miyata³

et al. 2014

Trends in Endocrinology & Metabolism

Self Cite

123

164

View full text Add to dashboard Cite

stromal cells via cell-cell contact or humoral factors. However, loss of tissue homeostasis leads to chronic inflammation and pathological tissue remodeling. Angiopoietin-like protein 2 (ANGPTL2) maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas excess ANGPTL2 activation induced by prolonged stress promotes breakdown of tissue homeostasis due to chronic inflammation and irreversible tissue remodeling, promoting development of various metabolic diseases. Thus, it is important to define how ANGPTL2 signaling is regulated in order to understand mechanisms underlying disease development. Here, we focus on ANGPTL2 function in physiology and pathophysiology.

show abstract

“…In vitro studies performed in skin squamous and HCC lines, as well as in lung and osteosarcoma cell lines, further support these findings (147,148,150,151). Interestingly, ANGPTL2 levels may represent a potential biomarker in various tumour types, such as breast (152) or oesophageal cancer (153). On the other hand, ANGPTL2 has been found to inhibit ovarian cancer cell growth in vitro (154).…”

Section: Angiopoietin-like Proteinmentioning

confidence: 65%

A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis

et al. 2016

View full text Add to dashboard Cite

Obesity, a pandemic disease, is caused by an excessive accumulation of fat that can have detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting different molecules that affect body physiology. In obesity, this function is altered, leading to a dysfunctional production of several factors, known as adipocytokines. This process has been linked to various comorbidities associated with obesity, such as carcinogenesis. In fact, several classical adipocytokines with increased levels in obesity have been demonstrated to exert a pro-carcinogenic role, including leptin, TNF-α, IL-6 and resistin, whereas others like adiponectin, with decreased levels in obesity, might have an anti-carcinogenic function. In this expanding field, new proteomic techniques and approaches have allowed the identification of novel adipocytokines, a number of which exhibit an altered production in obesity and type 2 diabetes and thus are related to adiposity. Many of these novel adipocytokines have also been identified in various tumour types, such as that of the breast, liver or endometrium, thereby increasing the list of potential contributors to carcinogenesis. This review is focused on the regulation of these novel adipocytokines by obesity, including apelin, endotrophin, FABP4, lipocalin 2, omentin-1, visfatin, chemerin, ANGPTL2 or osteopontin, emphasizing its involvement in tumorigenesis.

show abstract

Serum ANGPTL2 Levels Reflect Clinical Features of Breast Cancer Patients: Implications for the Pathogenesis of Breast Cancer Metastasis

Abstract: These findings suggest that serum ANGPTL2 levels in breast cancer patients could represent a potential marker of breast cancer metastasis.

Cited by 39 publications

References 20 publications

Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

Diverse roles of ANGPTL2 in physiology and pathophysiology

A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis

Contact Info

Product

Resources

About