Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

Abstract

Molecular balance between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) has important effects in tumor angiogenesis. Ang-2 was shown to be elevated and proved to be a prognostic factor in acute myeloid leukemia (AML). To date studies revealed increased angiogenesis in bone marrows (BMs) of both myeloproliferative neoplasm (MPN) and AML patients. We conducted this study to demonstrate circulating levels of Ang-1 and Ang-2 in MPN patients since no data exists in literature. Thirty-three newly diagnosed MPN, 27 newly diagnosed AML patients and 25 controls (HC) were enrolled and Angiopoietin levels were determined with ELISA. We found that Ang-1 levels were higher whereas Ang-2 levels were lower in MPN and HC when compared to AML. Our results suggest that though angiogenesis is increased in both AML and MPN, angiopoietin serum level profile of the two diseases are different, and MPN patients have similar Ang-1 and Ang-2 levels as HC. We conclude that, according to our results Ang-1 and Ang-2 do not only regulate tumor angiogenesis and the difference between angiopoietin levels of acute and chronic myeloid neoplasms could be a reflection of other effects of these growth factors on tumor malignancy.

Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection

“…In cancer patients, however, this expressional pattern of Ang-1 and Ang-2 is perturbed. The serum levels of Ang-2 in cancer patients increase and the ratio between Ang-1 and Ang-2 in circulation decreases significantly [28][29][30][31]. This alteration in Ang-1 and Ang-2 expressional patterns in cancer patients seems to be concordant with the well-defined functions of these two angiogenic factors described earlier.…”

Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer

“…Moreover, much higher serum Ang-2 levels in patients with LVSI might also reveal the fact that Ang-2 is a potential biomarker that can be used in the evaluation of staging. Although some evidence suggests that the expression of Ang-2 in tumor tissue indicates poor prognosis, only a few studies evaluated the levels of Ang-2 in circulation [46][47][48][49][50]. However, so far there has been no uniform conclusion.…”

Investigating the expression pattern of the angiopoietin-Tie system in ALL and its correlation with baseline characteristics

“…On the other hand, Atesoglu et al . [ 30 ] and Karakurt et al . [ 20 ] demonstrated that the expression of Ang1 was reduced in AML and ALL patients, similar to the findings of our study.…”

“…Our study showed a significantly increased expression of Ang2 in ALL patients compared to that observed in the control group. Numerous studies have been performed to evaluate the expression of this gene in hematological malignancies, all of which have shown an increase in patient Ang2 expression levels compared to the control group [ 20 , 23 , 30 - 32 ]. However, a study by Cheng et al .…”