Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer

Park, Joo Hun; Choi, Hye Won; Kim, Young Bae; Kim, Young Sun; Sheen, Seung Soo; Choi, Jin-Hyuk; Lee, Hye Lim; Lee, Keu Sung; Chung, Woo Young; Lee, Sungsoo; Park, Kyung Joo; Hwang, Sung Chul; Lee, Kyi Beum; Park, Kwang Joo

doi:10.1016/j.lungcan.2009.03.002

Cited by 28 publications

(32 citation statements)

References 34 publications

(56 reference statements)

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“…However, the precise reason from a clinical standpoint for a poor prognosis still remains unknown and there is no other established biomarker that is correlated to postoperative recurrence clinically. Recent studies reported the possibility that chemokine receptors 7 and angiopoietin-1 are potential markers of for predicting disease-free survival and recurrence in patients with early stage NSCLC [21,22].…”

Section: Discussionmentioning

confidence: 99%

TS expression predicts postoperative recurrence in adenocarcinoma of the lung

Shimokawa¹,

Uramoto²,

Onitsuka³

et al. 2011

Lung Cancer

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Section: Discussionmentioning

confidence: 99%

TS expression predicts postoperative recurrence in adenocarcinoma of the lung

Shimokawa¹,

Uramoto²,

Onitsuka³

et al. 2011

Lung Cancer

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“…Both factors are competitive ligands for tyrosine kinase (Tie-2), which is a receptor discovered on vessel endothelial cells, and form a dynamic balance system for regulation of angiogenesis (Suri et al 1996;Davis et al 1996;Maisonpierre et al 1997). Previous studies had performed to reveal the significances of Ang-1 and Tie-2 on many types of cancer (Caine et al 2003;Niedźwiecki et al 2006;Park et al 2009). Our study only focused on Ang-2, but not included Ang-1 and Tie-2.…”

Section: Chemotherapy Response No Of Patients (N)mentioning

confidence: 99%

Elevated Serum Level of Angiopoietin-2 as a Potential Marker for Poor Prognosis in Small Cell Lung Cancer

Zhang

Yang

et al. 2015

Tohoku J. Exp. Med.

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Small cell lung cancer (SCLC) is a fast-growing cancer with poor prognosis. Patients with extensive-stage SCLC are generally treated with chemotherapy. Thus, it is essential to identify a predictor of efficacy and prognosis for SCLC. Angiopoietin-2 promotes vascular remodeling and angiogenesis. Increasing evidence reveals that angiopoietin-2 is preferentially expressed in cancer cells, and elevated angiopoietin-2 expression is related to invasive and metastatic phenotypes in various cancers. However, serum angiopoietin-2 level and its prognostic potential in SCLC have not been investigated. The aim of this study was to determine the usefulness of angiopoietin-2 level as a predictor of efficacy and prognosis for SCLC. This study consisted of sixty patients with SCLC. Each patient received four cycles of cisplatin-etoposide chemotherapy, and was followed for 36 months. Serum angiopoietin-2 levels were measured by Enzymelinked immunosorbent assays. The angiopoietin-2 levels were significantly higher in SCLC patients than those in healthy subjects (P < 0.001). The patients were divided into high-level group (32 patients, 2,923.9 ± 294.7 pg/ml) and low-level group (28 patients, 1,789.5 ± 355.1 pg/ml) according to the mean value of the angiopoietin-2 level (2,400 pg/ml). Compared with the patients in the high-level group, the patients in the low-level group showed remarkably survival advantage (P = 0.002). During chemotherapy, the patients in the low-level group showed better treatment response than the patients in the high-level group (P < 0.05). Therefore, angiopoietin-2 might be useful as a prognostic factor for SCLC and for predicting SCLC response to chemotherapy.

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“…In cancer patients, the levels of Ang-1 decrease while the levels of Ang-2 increase significantly, and higher levels of Ang-2 are associated with poor prognosis of cancers. 22,23 To selectively target Ang-2 for cancer treatment, Amgen, Inc. developed two Ang-2 inhibitors named AMG-386 and L1-10, which are small peptides that bind with high affinity to Ang-1 or Ang-2 to prevent their interactions with Tie-2. 24 AMG-386 has an affinity for both Ang-1 and Ang-2 while L1-10 only binds to Ang-2.…”

Section: Introductionmentioning

confidence: 99%

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

Sha

Shao

et al. 2016

Cell Cycle

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Kaposi's sarcoma (KS) is a highly angiogenic and inflammatory neoplasia. The angiogenic and inflammatory cytokine angiopoietin-2 (Ang-2) is strongly expressed in KS due to Kaposi's sarcoma-associated herpesvirus (KSHV) infection. In the present study, we determined how Ang-2 contributes to development of KS by using telomerase-immortalized human umbilical vein endothelial cells (TIVE) as a model, which become malignantly transformed and express increased levels of Ang-2 following KSHV infection. Ang-2 released from TIVE-KSHV cells induces tyrosine phosphorylation of Tie-2 receptor from both human and mouse endothelial cells and promotes angiogenesis in nude mice. Functional inhibition or expressional "knock-down" of Ang-2 in these cells blocks angiogenesis and inhibits tumor growth. Ang-2 suppression also reduces the numbers of infiltrating monocytes/macrophages in tumors. In transwell-based cell migration assays, Ang-2 indeed enhances migration of human monocytes in a dose-dependent manner. These results underscore a pivotal role of KSHV-induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation. Our data also suggest that selective drug targeting of Ang-2 may be used for treatment of KS.

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Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer

Cited by 28 publications

References 34 publications

TS expression predicts postoperative recurrence in adenocarcinoma of the lung

TS expression predicts postoperative recurrence in adenocarcinoma of the lung

Elevated Serum Level of Angiopoietin-2 as a Potential Marker for Poor Prognosis in Small Cell Lung Cancer

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

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