Serum Angiogenesis Markers and Their Correlation with Ultrasound-Detected Synovitis in Juvenile Idiopathic Arthritis

Świdrowska, Joanna; Smolewski, Piotr; Stańczyk, Jerzy; Smolewska, Elżbieta

doi:10.1155/2015/741457

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…In our own studies, we observed a similar relationship between VEGF and its soluble sVEGFR-1 receptor. The inverse relationship was related to the sVEGFR-2 receptor, which could be associated with high affinity of VEGF to the Flt-1 receptor [54]. In patients with RA – contrary to the results of our research – Lee et al found no significant difference between serum VEGF and synovial fluid taken from 32 patients [55].…”

Section: Role Of Angiogenesis In Rheumatoid Processescontrasting

confidence: 87%

A fresh look at angiogenesis in juvenile idiopathic arthritis

Świdrowska-Jaros¹,

Smolewska²

2018

cejoi

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Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity.The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis.

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Section: Role Of Angiogenesis In Rheumatoid Processescontrasting

confidence: 87%

A fresh look at angiogenesis in juvenile idiopathic arthritis

Świdrowska-Jaros¹,

Smolewska²

2018

cejoi

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“…Interestingly, VE-cadherin is not the only endothelial protein affecting the development of inflammation within the course of JIA. Vascular endothelial growth factor (VEGF) is the best recognized and the most endothelial-specific angiogenic factor, and its higher concentrations in serum and synovial fluid were reported in JIA patients [ 26 ]. However, the authors were unable to measure VE-cadherin levels in synovial fluid in the recent study.…”

Section: Discussionmentioning

confidence: 99%

How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process

Orczyk

Smolewska

2020

Disease Markers

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Introduction. Vascular endothelial cadherin (VE-cadherin) is a calcium-dependent protein essential for stabilization of the adherens junctions of the endothelial cells. Through vasculogenic mimicry, VE-cadherin may influence angiogenesis in synovial fibroblast-like cells. The soluble extracellular domain of VE-cadherin may be considered an indicator of endothelial dysfunction. Its potential as a diagnostic biomarker in rheumatic diseases, including juvenile idiopathic arthritis (JIA), needs to be investigated. Materials and Methods. The study group included 80 patients diagnosed with JIA. In 53 individuals, blood samples were obtained twice with an average interval of 102.4 ± 4.6 days. Results from the study group were compared to 29 age- and sex-matched healthy children. Results. Serum levels of VE-cadherin were significantly higher in JIA patients than in healthy controls. In such comparison, VE-cadherin had 87.5% sensitivity and 69.0% specificity for the cutoff level 4.36 ng/ml (Youden index 0.56, area under the curve 0.724). VE-cadherin concentrations negatively correlated with the disease activity score. However, such finding may be a false result because of the downregulation of VE-cadherin induced by glucocorticosteroids. Conclusions. VE-cadherin may become a promising diagnostic biomarker of early stages of JIA. Its predictive significance may be decreased by utilization of glucocorticosteroids. A multicentre study including patients with other arthritides is recommended for further evaluation of this protein.

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“…They found a significant correlation of joint vascularization intensity with higher serum VEGF. However, oligoarticular JIA was the major subtype of the study population (69.8%) and remaining was polyarticular JIA [22]. In another important study with 12 DMARD naïve early RA patients, Kelly S. et al analyzed the relationship of US detected synovitis and synovial vascularity with various angiogenic, lymphangiogenic factors and cellular inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Association of Angiogenic and Inflammatory Markers with Power Doppler Ultrasound Vascularity Grade and DAS28-CRP in Early Rheumatoid Arthritis: A Comparative Analysis

Misra

Mondal

Chatterjee

et al. 2018

BioMed Research International

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Objective Upregulation of various proinflammatory and angiogenic mediators orchestrates the typical pathological synovial alterations in rheumatoid arthritis (RA). DAS28-CRP is commonly used for assessment of RA disease activity and power Doppler ultrasonography (PDUS) is an important modality for assessing synovial vascularity. This study was intended to look for the association of various inflammatory and angiogenic mediators, with respect to different PDUS vascularity grades and disease activity status, in early RA patients. Methods 50 early RA patients (<6 months disease duration) with either moderate or high disease activity and 30 healthy controls were included in this study. RA patients were subcategorized based on PDUS vascularity grading of wrist joints. Serum levels of proinflammatory cytokines [tumor necrosis factor-α (TNF- α); interleukin-6(IL-6)] and angiogenic markers [angiopoietin-1 and 2 (Ang-1 and Ang-2); vascular endothelial growth factor (VEGF) ] were measured and compared among different patient subgroups. Results Among 50 patients, 22 and 28 patients had moderate and high DAS28-CRP score, respectively. Patients with grade 3 PDUS score, even with moderate DAS value, showed a significant rise in Ang-1 (p<0.02), VEGF (p<0.008), Ang-2 (p <0.001), and TNF-α (p<0.005) level compared to grade 2 PDUS patients with high DAS values. Conclusion Higher serum level of angiogenic and inflammatory markers was noted among patients with moderate disease activity but with advanced PDUS vascularity (grade 3) in comparison to high disease activity group with less severe PDUS vascularity (grade 2). PDUS vascularity grading better reflects some markers of angiogenesis and inflammation, than composite disease activity index.

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Serum Angiogenesis Markers and Their Correlation with Ultrasound-Detected Synovitis in Juvenile Idiopathic Arthritis

Cited by 13 publications

References 23 publications

A fresh look at angiogenesis in juvenile idiopathic arthritis

A fresh look at angiogenesis in juvenile idiopathic arthritis

How Does Endothelial Permeability Affect the Development of Juvenile Idiopathic Arthritis? Vascular Endothelial Cadherin as a Promising New Tool Helpful in the Diagnostic Process

Association of Angiogenic and Inflammatory Markers with Power Doppler Ultrasound Vascularity Grade and DAS28-CRP in Early Rheumatoid Arthritis: A Comparative Analysis

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