Serum and whole blood Zn, Cu and Mn profiles and their relation to redox status in lung cancer patients

Zabłocka‐Słowińska, Katarzyna; Płaczkowska, Sylwia; Prescha, Anna; Pawełczyk, Konrad; Porębska, Irena; Kosacka, Monika; Pawlik-Sobecka, Lilla; Grajeta, Halina

doi:10.1016/j.jtemb.2017.09.024

Cited by 64 publications

(52 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results show an increase in the concentration of zinc in human plasma of CD patients compared to the healthy control. This result is consistent with that of Pasha et al and is contrary to that of Zablocka‐Slowinski et al and Marco et al Zinc has many important physiological and metabolic roles. Its antioxidants functions are also important for its protective effects against cancer .…”

Section: Resultssupporting

confidence: 92%

“…In our study, the concentration of Cu in the plasma of cancer patients was significantly lower than that of healthy controls. Which is in agreement with Khoshdel et al, while, it is contrary to the finding of Zablocka‐Slowinska et al, Marco et al, and Emre et al Since the copper is a transition active redox metal, it plays an important role in several normal immune function disorders . Where it is bound to numerous enzymes, either, as a cofactor or as an allosteric component .…”

Section: Resultssupporting

confidence: 83%

See 1 more Smart Citation

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

et al. 2019

View full text Add to dashboard Cite

Cancers are among the leading causes of morbidity and mortality in the world.The purpose of this study was to conduct a survey on the effect of minerals on cancer risk in the Algerian population. One hundred and seventy-eight plasma samples were used to analyze the concentrations of iron (Fe), copper (Cu), and zinc (Zn) in cancerous patients and also in healthy subjects using the X-ray florescence technique (XRF). Samples were classified according to the age and gender of the donors. An empirical formula was developed for the concentration of Zinc, Copper and Iron in cancer patients according to the age. The averages iron, copper and zinc concentrations in mg/kg for control and Cancer disease groups were (1493 ± 105; 1496 ± 86), (1172 ± 229; 1078 ± 283) and (1266 ± 202; 1344 ± 208) respectively. The ANOVA One-Way test was applied. For both genders of control and cancer disease groups it shows a significant decrease rate of copper for global and female gender and a significant increase rate of zinc for global and male gender (p < 0.05). The results indicate that the Cu and Zn concentration could show helpful tools for diagnosis and preventive treatment of cancer diseases.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 83%

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, this study evaluated biological associations with metal levels in whole blood samples, rather than commonly used plasma and serum samples. Some studies showed that whole blood can more comprehensively re ect the long-term status of metals in the body, and may not be markedly affected by current dietary intake [38,39]. Moreover, this study considered the interaction between elements, and provided the analysis of single elements, as well as the combined action of multiple metals.…”

Section: Discussionmentioning

confidence: 99%

Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6–12-year-old rural Chinese children: 2010–2012 China National Nutrition and Health Survey

Zhang

Man

Song

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Copper (Cu), magnesium (Mg) and zinc (Zn) are essential elements that participate in a series of oxidative stress and inflammation pathways related to metabolic reactions. Many studies have analyzed the relationship between Cu, Mg and Zn and metabolic syndrome (MetS) in adolescents and adults, but there have been few studies of children. We aimed to investigate the association of whole blood Cu, Mg and Zn with MetS components in 6–12-year-old rural Chinese children. Methods: A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were enrolled from the 2010–2012 China National Nutrition and Health Survey. Basic characteristics, metals and MetS component parameters were collected. Multivariate logistic regression analysis was performed to examine the independent relationship between metals and the incidence of MetS components.Results: Copper was positively associated with elevated waist circumference when analyzed alone (OR=2.00, 1.18–3.28). Combined with Zn, this association approached zero. For elevated triglyceride levels, the combination of low Cu and high Zn showed the opposite association with triglyceride relative to Cu alone (OR=2.21, 1.18–4.13 versus OR=0.33, 0.16–0.65, respectively), but was similar to the analysis of Zn alone (OR=2.12, 1.10–4.10). There was no association between whole blood Mg and waist circumference. However, the presence of both high Cu and high Mg levels significantly increased the risk of waist circumference exceeding the standard value (OR=2.03, 1.26–3.27). In addition, separate analysis of the distribution of Mg and Zn found no association with the risk of reduced high density lipoprotein-cholesterol (HDL-C); but high Zn combined with low Mg negatively associated with the risk of reduced HDL-C levels (OR=0.47, 0.28–0.77). Conclusions: Both the single and combined effects of Cu, Mg and Zn were associated with components of MetS. These results indicate the importance of combined analysis of multiple elements, and also provide new avenues for the early screening of MetS. The current results need to be further investigated in future work and other populations.

show abstract

“…The free Cu ion is transported through the BBB into the brain parenchyma, where it is utilized and released into the CSF 5 . Although an increased content of blood Cu has been associated with solid tumors, hematological malignancies 21,22 , and cancer progression (due to its key role in angiogenesis) 4 , no relationship between altered Cu level and brain cancers has been found. This is in agreement with the findings of the current study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex-and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis. The importance of trace metals in the neurosciences has become more compelling during the first decade of the 21 st century 1 , as there is considerable interest in finding the relationships between trace metals and various neurological diseases, including central nervous system (CNS) malignancies. Metals show their harmful effects at the first stage of cancerogenesis (initiation) 2. Initiation can affect normal biochemical reactions, leading to alterations in metal profiles. Considering that trace metals play a significant role in neoplastic processes, the metal contents in neoplastic samples can differ from the composition in control ones 3. Homeostasis of metals within tight physiological limits is maintained through the mechanisms of uptake, distribution, accumulation, and secretion. Each breakdown has deleterious effects on metal-regulated metabolic pathways and can be a crucial step in the pathogenesis of various diseases. The most important pathway in metal-induced cancerogenesis is the ability of a metal to modulate gene expression by interfering with signal transduction pathways, leading to the deregulation of cell proliferation, activation of numerous transcription factors, disruption of cell cycle course, and apoptosis 4. Metal homeostasis is critical for the proper functioning of the brain 5. The brain is a target organ for toxic environmental pollutants 6. The balance of metals within the brain is regulated through the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier. In physiological conditions, these barriers regulate CNS homeostasis

show abstract

Serum and whole blood Zn, Cu and Mn profiles and their relation to redox status in lung cancer patients

Cited by 64 publications

References 40 publications

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6–12-year-old rural Chinese children: 2010–2012 China National Nutrition and Health Survey

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Contact Info

Product

Resources

About