Serum and Urine Markers of Bone Metabolism During the Year After Hip Fracture

Abstract

Currently, the standard treatment of care for hip fractures still results in high morbidity and mortality and failure to regain prefracture quality of life. Gaining an understanding of bone cell activity in these patients after hip fracture, derived by measuring markers longitudinally during recovery, provides a baseline by which to measure the effectiveness of new interventions to improve recovery from hip fracture.

Biochemical markers of bone turnover are influenced by recently sustained fracture

“…Alkaline phosphatase (S-Bone ALP), on the other hand, may be more involved also in the continuous mineralization processes [28]. The different markers may thus reflect different stages of osteoblastic development and function, which would be one possible explanation for the divergent findings of the markers of bone formation.…”

Changes in Biochemical Markers after Lower Limb Fractures

“…The initial decrease in bone formation markers and the marked increase in ICTP immediately after fracture are mediated by immobilization and osteosynthesis after injury. Markers of bone turnover remain increased even after bone union is completed (11,(17)(18)(19). Background: Training of clinical pathologists is evolving and must now address the 6 core competencies described by the Accreditation Council for Graduate Medical Education (ACGME), which include patient care.…”

Longitudinal study of vitamin D metabolites after long bone fracture

“…(12) The third, and largest, study investigated 205 white women aged >65 years with proximal femoral fracture at baseline, and at 10, 60, 180, and 360 days thereafter; serum 1,25(OH) 2 D concentration fell at 10 and 60 days postfracture, before recovering to baseline levels at 360 days; serum concentrations of 24R,25(OH) 2 D were not determined in this study. (13) These studies suffer from two key limitations. First, none has determined serum 24R,25(OH) 2 D concentrations within 2 weeks of fracture; this is significant because in animal models, serum 24R,25(OH) 2 D concentrations peak at 10 days postfracture and normalize thereafter.…”