Serum and Urine Levels of Zinc and Selenium in Diabetics in Calabar, Nigeria

Trace Elements in Diabetes Mellitus

“…In the present study, serum zinc levels were found to be significantly lowered in diabetic group (p<0.001), which was in correlation with findings of Chausmer AB et al, [3] A C Nsonwu et al, [14] and Alena Viktorinovaa et al, [30].…”

“…Hyperglycaemia has been postulated to interfere with the active transport of zinc back in to the tubular cells [14,3]. Other possible causes may be disturbed metabolisms of zinc metalloenzymes and an abnormal binding of zinc to tissue proteins, which cause hyperzincuria.…”

“…Its deficiency has been implicated in insulin resistance, carbohydrate intolerance, dislipidaemia and complications of diabetes [13]. The association between diabetes It is not known whether trace element status leads to disease or whether diseases sets in due to deficiency of trace elements [14].…”

Status of Serum Zinc and Magnesium among Type 2 Diabetic Subjects in Maiduguri

“…In their study, there was significantly low level of serum zinc in diabetics as compared to controls. Same study were carried out by Nsonwu et al [26], Chausmer et al [3], Naila et al [27] and Alena et al [28] and serum zinc was found to be significantly lower in diabetic group. In our study, there was no significant difference in the means of serum magnesium in type 2 diabetics as compared to controls.…”

Copper, Zinc and Magnesium in Non-Insulin-Dependent Diabetes Mellitus Treated with Metformin

“…There are some research data confirming that patients with type 1 and type 2 diabetes mellitus have increased levels of zinc concentration in urine. [54] Increased urinary levels of this cation can be involved in the plasmatic reduced levels, and the mechanism involved may be due to hyperglycemia that can interfere with the Zn transport back in renal tubular cells, but we cannot exclude other interventions of zinc ions on the zinc transporters.…”