Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis

Sheu, Ji-Nan; Chen, Meng-Chi; Ko, Jiunn‐Liang; Cheng, Sun-Long; Lee, Inn‐Chi; Chen, Shan-Ming; Tsay, Gregory J.

doi:10.1016/j.cyto.2007.02.006

Cited by 106 publications

(134 citation statements)

References 30 publications

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“…This difference, comparing UTI with ASB, has also been found in children [9]. Urine IL-6 was elevated in children and adults with UTI [13,17,23,27], and urinary levels of IL-6 in UTI reflected disease severity [17,19,28]. With the exception of an early study by Nicolle [15] this is, to our knowledge, the first study evaluating urinary cytokine response in relation to bacteriuria in an elderly population.…”

Section: Discussionmentioning

confidence: 79%

Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria

Rodhe

Löfgren

Strindhall

et al. 2009

Scandinavian Journal of Primary Health Care

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Section: Discussionmentioning

confidence: 79%

Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria

Rodhe

Löfgren

Strindhall

et al. 2009

Scandinavian Journal of Primary Health Care

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“…Studies have shown that UPEC triggers inflammation that consists of immune mediators, including ILs (9)(10)(11)(12), although some of these responses, including, for example, IL-1a, occur in a pathogen-specific manner (13). Roles for TNF, NO (14), CXCR 2 (15), Tamm-Horsfall protein (16,17), and CD44 (18) have been shown in models of human UPEC UTI, although, in most cases, the functions of these host factors at the cellular and molecular levels remain unclear.…”

mentioning

confidence: 99%

Innate Transcriptional Networks Activated in Bladder in Response to Uropathogenic Escherichia coli Drive Diverse Biological Pathways and Rapid Synthesis of IL-10 for Defense against Bacterial Urinary Tract Infection

Duell

Carey

Tan

et al. 2012

The Journal of Immunology

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Early transcriptional activation events that occur in bladder immediately following bacterial urinary tract infection (UTI) are not well defined. In this study, we describe the whole bladder transcriptome of uropathogenic Escherichia coli (UPEC) cystitis in mice using genome-wide expression profiling to define the transcriptome of innate immune activation stemming from UPEC colonization of the bladder. Bladder RNA from female C57BL/6 mice, analyzed using 1.0 ST-Affymetrix microarrays, revealed extensive activation of diverse sets of innate immune response genes, including those that encode multiple IL-family members, receptors, metabolic regulators, MAPK activators, and lymphocyte signaling molecules. These were among 1564 genes differentially regulated at 2 h postinfection, highlighting a rapid and broad innate immune response to bladder colonization. Integrative systems-level analyses using InnateDB (http://www.innatedb.com) bioinformatics and ingenuity pathway analysis identified multiple distinct biological pathways in the bladder transcriptome with extensive involvement of lymphocyte signaling, cell cycle alterations, cytoskeletal, and metabolic changes. A key regulator of IL activity identified in the transcriptome was IL-10, which was analyzed functionally to reveal marked exacerbation of cystitis in IL-10–deficient mice. Studies of clinical UTI revealed significantly elevated urinary IL-10 in patients with UPEC cystitis, indicating a role for IL-10 in the innate response to human UTI. The whole bladder transcriptome presented in this work provides new insight into the diversity of innate factors that determine UTI on a genome-wide scale and will be valuable for further data mining. Identification of protective roles for other elements in the transcriptome will provide critical new insight into the complex cascade of events that underpin UTI.

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“…Urinary tract infection activates topical and systemic cytokine responses; also, release of cytokines from the site of infection triggers the fever, acute phase response and neutrophilic response (Sheu et al, 2006). IL-8 is one of the important mediators of early inflammatory response and an agent for influx of neutrophils to the site of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteria causing UTI activates both systemic and local inflammatory responses in which the cytokines play a central role (Sheu et al, 2006). Uropathogenic Escherichia coli that is the most common factor of UTI, stimulates the epithelial cells of the urinary tract and secretion of interleukin 8 (IL-8) (Funfstuck et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Interleukin-8 in Differentiation of Acute Pyelonephritis from Cystitis in Children

Kajbaf¹,

Valavi²,

Nikfar³

et al. 2015

Asian J. of Cell Biology

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Urinary Tract Infection (UTI) is a relatively common infection in children that can lead to serious complications such as renal scarring, hypertension and chronic renal failure. In this study we stressed the role of IL-8 in the diagnosis and differentiation between pyelonephritis and cystitis. This prospective descriptive study was conducted among 86 children one month to 14 years, who with clinical signs and symptoms of suspected urinary tract infections were referred to Ahvaz Aboozar hospital. Among 86 children studied 16 (18.6%) and 70 (81.4%) children were boy and girl, respectively. E. coli and Klebsiella were obtained from urine samples of 72 patients (83.7%) and seven patients (8.1%), respectively. The frequency of abdominal pain in pyelonephritis and cystitis groups was 10.4 and 18.4%, respectively. Vomiting in the pyelonephritis and cystitis groups was respectively 22.9 and 10.5%. The frequency of diarrhea in the pyelonephritis and cystitis groups was 4.2 and 2.6%, respectively. In general, dysuria was the most common symptom in the two groups (69.8%). Measurement of cytokines only takes a few hours and to do it is the easy and non-invasive. Based on the study system the mean IL-8/Cr for detecting pyelonephritis in level 7 has the sensitivity of 66% and the specificity of 72% and even the increased IL-8 after the initial experimental treatment can be a sign for the continued inflammation or antibiotic resistance. Obviously, in this recent case wider study must be carried out.

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Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis

Cited by 106 publications

References 30 publications

Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria

Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria

Innate Transcriptional Networks Activated in Bladder in Response to Uropathogenic Escherichia coli Drive Diverse Biological Pathways and Rapid Synthesis of IL-10 for Defense against Bacterial Urinary Tract Infection

Diagnostic Accuracy of Interleukin-8 in Differentiation of Acute Pyelonephritis from Cystitis in Children

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