Serum and urinary selenium levels in thermal injury

Boosalis, Maria G.; Solem, Lynn D.; Ahrenholz, David H.; McCall, John T.; McClain, Craig J.

doi:10.1016/0305-4179(86)90122-1

Cited by 52 publications

(49 citation statements)

References 23 publications

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“…Silver has a good safety profile, but most published data relate to its short-term use. Patients with extensive burns who receive local treatment with preparations containing silver have been shown to have serum concentrations of up to 60 µg/dL and urine concentrations of 1,100 μg in 24 hours without developing clinical consequences or signs of argyria [35]. However, in a previous clinical trial [36], 10 percent of men reported a black discharge and irritation from the study's silver-coated catheter; these results were not noted in the control group.…”

Section: Discussionmentioning

confidence: 91%

Silver hydrogel urinary catheters: Evaluation of safety and efficacy in single patient with chronic spinal cord injury

Estores¹

2008

JRRD

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Abstract-Urinary tract infections (UTIs) are a large health burden for patients with spinal cord injury (SCI) who have neurogenic bladder dysfunction, especially those patients using indwelling catheters. One method that has shown promise in recent years is the use of a silver hydrogel catheter (SHC). This article describes the outcome of a subject who was part of a prospective, randomized, double-blind study and assigned to use an SHC for 6 months. Using the indwelling SHC effectively prevented this subject from developing a symptomatic UTI. He did not display any symptoms suggestive of silver toxicity or increased serum levels of silver with chronic use of the device. Although no general conclusions can be drawn from this single-subject observation, the results suggest that SHC use has a positive effect. Use of this catheter for persons with neurogenic bladder dysfunction after SCI should be explored further with a study design that optimizes subject recruitment.

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Section: Discussionmentioning

confidence: 91%

Silver hydrogel urinary catheters: Evaluation of safety and efficacy in single patient with chronic spinal cord injury

Estores¹

2008

JRRD

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“…The absorption of silver is greatest during the inflammation and cell proliferation phases of wound healing [6,19,20]. Urinary silver excretion may increase a thousand-fold when silver compounds are used to treat large open wounds (burns) for prolonged periods of times [11,18]. This appears to have no clinical significance [11].…”

Section: Biochemistry and Physiologymentioning

confidence: 97%

“…Silver nitrate has been utilized as a topical burn treatment since 1965 and silver sulfadiazine has been a mainstay of burn care since 1968 [13][14][15]. As much as 10% of silver sulfadiazine may be absorbed through partial thickness burns that have good vascularity [2,16] with blood silver levels of >300 mg/L measured [2,[16][17][18]. The absorption of silver is greatest during the inflammation and cell proliferation phases of wound healing [6,19,20].…”

Section: Biochemistry and Physiologymentioning

confidence: 99%

Silver in medicine: The basic science

Marx

Barillo²

2014

Burns

127

102

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“…5,32 Interestingly, we noted that once the silver-impregnated dressing was removed, the leukopenia abated despite continued increase in the patient's serum silver level, suggesting that there may be an association with silver that is amplified by the direct application to a wound surface.…”

Section: Discussionmentioning

confidence: 94%

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

LaRiviere

Goldin

Avansino

2011

The Journal of the American College of Certified Wound Speciali

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Silver-containing topical agents are used to help prevent infectious complications in wound therapy. Toxicity from topical silver agent exposure was initially reported in 1975 and was clinically characterized by granulocytopenia. Currently, the data regarding potential toxicity associated with silver-impregnated devices are limited. A 23-year-old patient receiving chemotherapy for acute lymphoblastic leukemia presented with necrotizing fasciitis of the abdominal wall and scrotum from a Crohn disease-related psoas-enteric fistula. Surgical debridement of the soft-tissue and abdominal musculature was performed to the peritoneum. Silver-containing foam sponges and wound vacuumassisted closure were applied directly to the peritoneum 2 weeks after initial debridement. Subsequently, the patient developed leukopenia, and workup revealed the serum silver level was 4 times normal level. Silver-impregnated sponges were discontinued and silver-free sponges and wound vacuum-assisted closure therapy resumed, followed by leukopenia resolution. Silver toxicity associated with routine application of silver-impregnated sponges has not been previously reported.

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Serum and urinary selenium levels in thermal injury

Cited by 52 publications

References 23 publications

Silver hydrogel urinary catheters: Evaluation of safety and efficacy in single patient with chronic spinal cord injury

Silver hydrogel urinary catheters: Evaluation of safety and efficacy in single patient with chronic spinal cord injury

Silver in medicine: The basic science

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

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