Serum and urinary magnesium in young diabetic subjects in Bangladesh

Khan, Laique A; Alam, A. M. Shafiqul; Ali, Liaquat; Goswami, Anupam; Hassan, Zurina; Sattar, Soheli; Banik, Nani G; Khan, Abid Hossain

doi:10.1093/ajcn/69.1.70

Cited by 26 publications

(18 citation statements)

References 15 publications

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“…17 In another study, prevalence was 42% in malnutrition related diabetes mellitus patients. 18 Conclusion From this study, it was found that hyponatraemia, hypokalaemia and hypomagnaesemia were common electrolyte imbalance in hospitalized diabetic patients. Prevalence of hyperkalaemia was less common.…”

Section: Discussionmentioning

confidence: 79%

Pattern of Electrolyte Imbalance in Hospitalized Diabetic Patients: Experience in a Tertiary Care Hospital

et al. 2012

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Pattern of Electrolyte Imbalance in Hospitalized DiabeticPatients 22% were on oral anti-diabetic agents and 6% were on medical nutrition therapy. Among the co-morbidities, hypertention was the most prevalent (61%), followed by ischaemic heart disease (24%), chronic kidney disease (21%), dyslipidaemia (8%) and fatty liver (4%). Diabetic peripheral neuropathy was present in 41% cases, nephropathy in 13% cases and retinopathy in 12% cases. Over all 78% (100 patients had electrolyte imbalance out of 128 patients) of patients had some sort of electrolyte imbalance, irrespective of cause of admission. Hyponatraemia was the most common electrolyte imbalance in this study (80%), followed by hypomagnaesemia (38%), hypokalaemia (36%) and hyperkalaemia (14%). In 11% cases there were hyponatraemia, hypokalaemia and hypomagnaesemia. Regarding the precipitating factors, vomiting was most common (51%). In 28% cases electrolyte imbalance was precipitated by various drugs. Diarrhea and renal failure were responsible in a minority of cases. In 4% cases no cause could be identified. No death occurred.Conclusion: From this cross-sectional study it can be concluded that, electrolyte imbalance is common in hospitalized diabetic patients. Serum electrolytes should be checked routinely in hospitalized diabetic patients irrespective of their purpose of admission.

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Section: Discussionmentioning

confidence: 79%

Pattern of Electrolyte Imbalance in Hospitalized Diabetic Patients: Experience in a Tertiary Care Hospital

et al. 2012

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“…So we believed that malnourishment did not interfere in PI size. In the literature on the other hand, an increase of the size of PI in experimentally obese animals 15 and a decreased size of the pancreas in malnourished children 16 has been described.…”

Section: Discussionmentioning

confidence: 99%

Morphologic and morphometric evaluation of pancreatic islets in chronic Chagas' disease

Saldanha

Santos²,

Reis³

et al. 2001

Rev. Hosp. Clin.

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Purpose: Hyperglycemia and abnormal glucose tolerance tests observed in some patients with chronic Chagas' disease suggest the possibility of morphological changes in pancreatic islets and/or denervation. The purpose of this study was to describe the morphology and morphometry of pancreatic islets in chronic Chagas' disease.Methods: Morphologic and computerized morphometric studies were performed in fragments of the head, body, and tail regions of the pancreas obtained at necropsies of 8 normal controls and 17 patients with chronic Chagas' disease: 8 with the digestive form (Megas) and 9 with the congestive heart failure form.Results: The Megas group had a larger (p < 0.05) pancreatic islet area in the tail of the pancreas (10649.3 ± 4408.8 µm 2 ) than the normal control (9481.8 ± 3242.4 µm 2 ) and congestive heart failure (9475.1 ± 2104.9 µm 2 ) groups; likewise, the density of the pancreatic islets (PI) was greater (1.2 ± 0.7 vs. 0.9 ± 0.6 vs. 1.9 ± 1.0 PI/mm 2 , respectively). In the tail region of the pancreas of patients with the Megas form, there was a significant and positive correlation (r = +0.73) between the area and density of pancreatic islets. Discrete fibrosis and leukocytic infiltrates were found in pancreatic ganglia and pancreatic islets of the patients with Chagas' disease. Trypanosoma cruzi nests were not observed in the examined sections. Individuals with the Megas form of Chagas' disease showed increased area and density of pancreatic islets in the tail of the pancreas.Conclusion: The observed morphometric and morphologic alterations are consistent with functional changes in the pancreas, including glycemia and insulin disturbances.

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“…They found significantly higher urinary magnesium (30 mmol/L versus 6.3 mmol/L, p<0.05) and low serum magnesium (0.66 mmol/L versus 0.73 mmol/L, p<0.05) in patients with diabetes mellitus from pancreatic disease compared to normal individuals. 19 A recent study by Xu et al, evaluated urinary magnesium levels in patients with prediabetes, type 1 and type 2 diabetes mellitus, with different end-organ complications of diabetes. Patients with type 1 or type 2 diabetes had significantly lower serum magnesium and higher urinary magnesium excretion compared to healthy controls.…”

Section: Urinary Magnesium Loss In Patients With Diabetesmentioning

confidence: 99%

Efficacy of Magnesium Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Meta-Analysis

Chua¹,

Cinco²,

Paz-Pacheco³

2017

JAFES

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Objective. To evaluate if magnesium supplementation, in addition to standard therapy, improves fasting blood sugar (FBS) and/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM) compared to placebo or other comparator.Methodology. We searched MEDLINE/PubMed, Cochrane Library, Acta Medica Philippina, Health Research and Development Information Network (HERDIN) and references of reviewed journals from 1966 to July 2015 using the following search terms: "magnesium" OR "magnesium supplementation" OR "magnesium replacement", AND randomized controlled trial AND diabetes OR diabetes mellitus OR non-insulin dependent diabetes mellitus OR diabetic OR diab* (with MeSH, where available). Studies were retrieved and rated independently using the standards provided by The Cochrane Collaboration. High quality trials were included in a systematic review and meta-analysis.Results. Of the 689 records screened, 10 studies were included in the qualitative synthesis and 7 studies in the metaanalysis. Pooled data showed a non-significant trend towards improvement in glycemic control in the magnesiumtreated group (mean difference -0.19, CI -0.58 to 0.21). There was a stronger but still non-significant trend in T2DM patients with hypomagnesemia (mean difference -1.16, CI -2.92 to 0.6).Conclusion. Routine magnesium supplementation for improvement in glycemic control in T2DM patients cannot be recommended based on data from included studies in this meta-analysis.

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Serum and urinary magnesium in young diabetic subjects in Bangladesh

Abstract: Malnutrition may not itself give rise to glucose intolerance, and serum magnesium deficiency seems to be a consequence rather than a cause of diabetes mellitus.

Cited by 26 publications

References 15 publications

Pattern of Electrolyte Imbalance in Hospitalized Diabetic Patients: Experience in a Tertiary Care Hospital

Pattern of Electrolyte Imbalance in Hospitalized Diabetic Patients: Experience in a Tertiary Care Hospital

Morphologic and morphometric evaluation of pancreatic islets in chronic Chagas' disease

Efficacy of Magnesium Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Meta-Analysis

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