Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer

Gadducci, Angiolo; Cosio, Stefania; Tana, Roberta; Genazzani, Andrea Riccardo

doi:10.1016/j.critrevonc.2008.05.001

Cited by 75 publications

(62 citation statements)

References 200 publications

(310 reference statements)

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“…It has also proven its value to predict recurrence and disease progression after primary therapy (4,6,7). However, the role of preoperative serum CA 125 as a prognostic tumor marker remains unclear as most studies could not show a significantly independent predictive effect (3,4,9,(11)(12)(13)(14)26). We found that preoperative serum CA 125 was a significant predictor of DFS in univariate analysis.…”

Section: Discussionsupporting

confidence: 51%

Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer

Kolwijck

Span²,

Thomas³

et al. 2009

Oncol Rep

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Abstract. Most ovarian tumors contain ovarian cyst fluid (oCF) which can be easily obtained during surgery. This is the first study that explored if CA 125 in oCF could be of prognostic value for patients with epithelial ovarian cancer (EOC). Of 54 patients with primary EOC, oCF and preoperative serum were collected and clinicopathological data were retrospectively obtained. CA 125 was measured with the commercially available CA 125 assay. CA 125 in oCF (n=54, median: 55,500 U/ml, range: 590-10,200,000 U/ml) was always higher than in the corresponding serum (n=51, median: 179 U/ml, range: 13-11,000 U/ml) (p<0.001) and values were moderately correlated (R=0.337, p=0.016). CA 125 in oCF was associated with histology (p<0.001) and tumor grade (p=0.038). High levels of oCF CA 125 (>median) were significantly associated with a poor diseasefree survival (DFS) (log-rank p=0.002 and p=0.005 univariate Cox-regression). Other factors associated with a poor DFS in univariate analysis were advanced FIGO stage, suboptimal debulking (both p<0.001), high tumor grade (p=0.025), serous histology (p=0.003) and high serum (>media) CA 125 (p=0.009). In multivariate analysis, only FIGO stage was of independent predictive value. These findings indicate that, although high levels of oCF CA 125 were significantly associated with a poor survival of EOC patients, CA 125 in oCF was not of independent predictive value and might therefore not be useful as a prognostic biomarker for EOC.

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Section: Discussionsupporting

confidence: 51%

Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer

Kolwijck

Span²,

Thomas³

et al. 2009

Oncol Rep

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“…Tissue expression and fluid levels of TNF-α have been associated significantly with ovarian cancers, but not with the benign tumors [10,11]. Inflammatory conditions related to the ovarian cancer include exposure to exogenous irritants and ovulation, accompanied by cell proliferation, oxidative stress, vascular permeability and overproduction of biological factors, such as prostaglandins, leukotrienes, TNF-α and other cytokines [5,10,16,17].…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Dobrzycka

Terlikowski²,

Garbowicz³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-α and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-α, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-α and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.Keywords: tumor necrosis factor-α (TNF-α); tumor necrosis factor receptor 1 (TNF-R1); tumor necrosis factor receptor 2 (TNF-R2); epithelial ovarian cancer (EOC) Correspondence: B. Dobrzycka,

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“…All of these known variables (except age) are amenable for assessment only after surgery. Various preoperative molecular markers such as serum CA-125, soluble cytokeratin fragments, serum human kallikreins, serum cytokines, serum vascular endothelial growth factor (VEGF) and plasma d-dimer have been assessed as prognostic variables for ovarian cancer with varied results [6]. CA-125 is the most useful and extensively studied molecular marker in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Established prognostic variables in ovarian cancer include age at diagnosis, International Federation of Obstetricians and Gynecologists (FIGO) tumour stage, histological type, tumour grade and presence of residual disease after initial surgery [6]. All of these known variables (except age) are amenable for assessment only after surgery.…”

Section: Introductionmentioning

confidence: 99%

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

et al. 2011

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Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer

Cited by 75 publications

References 200 publications

Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer

Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer

Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

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