Serum and tissue angiotensin converting enzyme in patients with lichen planus

Alendar, Faruk; Huskić, Jasminko; Babić, Nermina; Mulabegović, Nedžad

doi:10.17305/bjbms.2005.3272

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…After therapy, serum and tissue ACE activity decreased and no significant difference in ACE activity was found. 9 Robati et al conducted a study of serum ACE levels in pemphigus in which 34 patients with pemphigus vulgaris and 35 healthy individuals were recruited. The mean serum ACE levels in patients and control groups were 25.34±14.25 and 31.97±19.44 respectively.…”

Section: Discussionmentioning

confidence: 99%

Study of serum angiotensin converting enzyme levels in pemphigus vulgaris

Kumar¹,

Shree²

2018

Int J Res Dermatol

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Background: This study aimed to evaluate the serum angiotensin converting enzyme (ACE) levels in patients with pemphigus vulgaris compared with healthy volunteers.Methods: In this study, 40 patients were selected in the study group with pemphigus vulgaris and 40 patients were selected in the control group i.e. healthy group. Serum ACE levels were determined by spectrophotometric method.Results: The mean ACE levels in study group and control group were 26.98±15.87 and 32.57±20.98 respectively. There was no statistically significant difference between both the groups (p=0.11). The mean ACE levels were 26.25±12.36 and 26.14±13.89 in females and males respectively in the study group which showed no significant difference (p=0.95). In the control group, the mean ACE levels were 26.22±19.77 and 38.54±11.11 in females and males respectively which showed a statistically significant difference (p=0.04). The mean ACE levels were higher in healthy males when compared to the males in the study group. The mean serum levels in females of both the groups were almost same.Conclusions: The serum ACE level was considerably lower in male study group i.e. pemphigus vulgaris patients compared with male control group i.e. healthy group, despite lack of any significant difference of serum ACE level between pemphigus and control group. Hence, ACE might have some relation with pemphigus vulgaris especially in male patients.

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Section: Discussionmentioning

confidence: 99%

Study of serum angiotensin converting enzyme levels in pemphigus vulgaris

Kumar¹,

Shree²

2018

Int J Res Dermatol

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“…There have been reported two cases suggesting that Captopril and Ramipril induced LP pemphigoides. Unfortunately, mechanisms are still unknown [131][132][133].…”

Section: Lichen Planus (Lp)mentioning

confidence: 99%

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Maranduca,

Cosovanu,

Clim

et al. 2023

Diagnostics

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Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more.

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“…These findings suggest that angiotensin II may contribute to oral LP through activating TRPA1. Given that circulating angiotensin-converting enzyme (the enzyme the produces angiotensin II) was upregulated in LP patients (Alendar et al, 2005), TRPA1 would be activated and upregulated in both lesion sites and non-lesion sites. However, unfortunately, this study (Kun et al, 2016) did not examine the expression levels of TRPA1 in non-lesion sites.…”

Section: Dear Editormentioning

confidence: 99%