Serum and small intestinal immunoglobulin levels in undernourished children

Abstract

Intestinal immunoglobulin levels were quantitated in undernourished Indonesian children with enteric infections and normally nourished Indonesians with and without enteric infections. These were compared to the same parameters in Australian Aboriginal children (also suffering undernutrition) and normal Caucasian children. Children with enteric infections displayed equally elevated levels of intestinal immunoglobulin irrespective of their nutritional status. Intestinal infections appeared to elevate IgG levels more than secretory IgA levels in the age group examined. However, it appeared likely that some of the EgG was serum-derived whereas the IgA appeared to be locally produced. There was no apparent deficiency in the capacity of undernourished children to manufacture and secrete immunoglobulin in the gut.

Efficacy of a Fish Protein Hydrolysate in Malnourished Children

“…The data is useful for comparison of immune status of children from different geographical regions of the country and elsewhere. Indonesian population 1443 ± 220 218 ± 19 143 ± 20 [22] Indian population (present study)…”

“…Interestingly, we have observed similar results in the current user trial study in malnourished children of the higher age group of 6-8 years. In a recent study, it was reported that intestinal immunoglobulin levels in the undernourished children among various ethnic populations such as Caucasian population, Indonesian and Australian Aboriginal populations were within the normal range (Table 5) [22]. The study showed no statistically significant differences among various groups of undernourished children.…”

Effect of a Low Protein Diet on the Capacity of Mice to Express a Type I Hypersensitivity Response

“…The majority of malnourished children in under developed countries carry a heavy burden of intestinal parasites [Sumarmo, personal commun.] which stimulate the synthesis of high levels of scrum IgE [5,9,13]. Prior in cubation of mast cells with serum from par asitized subjects inhibits subsequent sensiti zation of the tissue with allergen specific IgE [8], It is reasonable to postulate there fore that the findings of Abbassy et al [1] could be explained on the basis that the IgE receptor sites on the skin mast cells of mal nourished children were already saturated with IgE, thus precluding further sensitiza tion in the P-K test.…”

Technical Report: results of immunological tests on faecal extracts are likely to be extremely misleading

“…Increasing numbers of papers draw inferences on the immune functions of the gut from measurements of faecal immunoglobulins, specific antibodies and eytokines [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Technical and analytical problems associated with the use of faeces are significant, and results obtained in this way have not generally been validated by comparison with determinations on directly collected gut secretions.…”