Serum and skin levels of miR-369-3p in patients with psoriasis and their correlation with disease severity

Guo, Sen; Zhang, Weigang; Wei, Chao; Wang, Lei; Zhu, Guannan; Shi, Qiong; Li, Shuli; Ge, Rui; Li, Kai; Gao, Lin; Gao, Tianwen; Wang, Gang; Li, Chunying

doi:10.1684/ejd.2013.2148

Cited by 45 publications

(36 citation statements)

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“…Specific miRNA expression profiles have been identified in psoriasis lesions, and some miRNAs ( e.g ., miR‐125b, miR‐31 and miR‐369‐3p) have been confirmed to be related with the genesis of psoriasis . Some high‐throughput studies have implicated that miR‐146a is increased in psoriatic lesions , which was also detected in the current study.…”

Section: Discussionsupporting

confidence: 83%

A single‐nucleotide polymorphism of miR‐146a and psoriasis: an association and functional study

Zhang

Guo

et al. 2014

J Cellular Molecular Medi

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Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study investigated the association between a functional SNP of rs2910164 in miR-146a and the risk of psoriasis in the Chinese Han population. A total of 521 Han Chinese patients with psoriasis and 582 healthy controls were recruited in this study. The miR-146a rs2910164 SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Overall, a significantly increased risk of psoriasis was associated with the rs2910164 miR-146a CG and GG genotypes (adjusted OR, 1.38; 95% CI, 1.06–1.80). Furthermore, the rs2910164G allele in miR-146a attenuated its inhibitory regulation on the expression of EGFR as well as the proliferation of human keratinocytes, and lowered the level of miR-146a in the psoriatic lesions. These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, which may account for the increased risk of psoriasis in this study population.

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Section: Discussionsupporting

confidence: 83%

A single‐nucleotide polymorphism of miR‐146a and psoriasis: an association and functional study

Zhang

Guo

et al. 2014

J Cellular Molecular Medi

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“…Meaningfully, serum and skin miR‐369‐3p levels in patients with psoriasis were detected and confirmed their correlation with disease severity, in which miR‐369‐3p levels in skin had a positive linear relation with PASI scores . Similar results were obtained in the investigation of miR‐223 and miR‐143 .…”

Section: Mirna As Potential Biomarkers In Psoriasissupporting

confidence: 77%

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

Liu

Han

et al. 2017

Experimental Dermatology

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MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.

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“…Among these miRNAs, miR‐203, miR‐146a, miR‐31, miR‐21, miR‐210 and miR‐369‐3p are increased, and miR‐125b is decreased in psoriasis compared to controls. These miRNAs regulate inflammatory autoimmune process via distinct pathways or/and targets (Table ).…”

Section: Mirnas In Autoimmune Diseases With Skin Involvementmentioning

confidence: 99%

“…One recent study showed that the expression of miR‐369‐3p was increased in serum samples and skin tissues from patients with psoriasis compared to healthy subjects. MiR‐369‐3p levels in skin had a positive linear relationship with psoriasis activity severe index (PASI) scores .…”

Section: Mirnas In Autoimmune Diseases With Skin Involvementmentioning

confidence: 99%

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

Deng

et al. 2015

Scand J Immunol

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MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively modulate gene expression by binding to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs), which leads to the degradation or translational repression of their target mRNAs. Previous research on miRNAs has revealed a new paradigm of gene regulations and pathways involved in the pathogenesis of autoimmune disorders and malignant diseases. The roles of miRNAs in cellular processes, including cell differentiation, proliferation, apoptosis and immune functions, are not clearly understood. MiRNAs are easily detected in a variety of sources, including tissues, serum and other body fluids, and this make them a good biological sample for pathogenic studies and disease biomarker development. This review encompasses the current understanding of the roles of miRNAs in autoimmunity and the cellular and molecular mechanisms of miRNAs in various autoimmune diseases (AIMDs). Specifically, we focus on the target genes of miRNAs and the biological processes associated with autoimmune diseases with skin involvement, including systemic lupus erythematosus, psoriasis, systemic sclerosis, Behcet's disease and dermatomyositis. In addition, the diagnostic and therapeutic relevance of miRNAs that are involved in autoimmunity are elucidated to provide information for clinical implications.

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Serum and skin levels of miR-369-3p in patients with psoriasis and their correlation with disease severity

Cited by 45 publications

References 0 publications

A single‐nucleotide polymorphism of miR‐146a and psoriasis: an association and functional study

A single‐nucleotide polymorphism of miR‐146a and psoriasis: an association and functional study

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

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