Serum and red blood cell folate levels in parturients, in the intervillous space of the placenta and in full-term newborns

Giugliani, Elsa Regina Justo; Jorge, Salim Moysés; Gonçalves, Arthur Lopes

doi:10.1515/jpme.1985.13.2.55

Cited by 34 publications

(24 citation statements)

References 8 publications

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“…The fetus is completely dependent on the delivery of folate from the mother via the placenta (Henderson et al, 1995) and the maternal folate concentration is reflected in the fetal concentration (Giugliani et al, 1985). Our immunohistochemical studies unambiguously demonstrated upregulation of FR in several fetal tissues in varying degrees, which reflected the adverse effects of sustained maternal folate deficiency on fetal nutrition.…”

Section: Upregulation Of Fr In Folate-deficient Fetusessupporting

confidence: 55%

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues

et al. 2005

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Section: Upregulation Of Fr In Folate-deficient Fetusessupporting

confidence: 55%

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues

et al. 2005

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“…With this method of collection it is possible to obtain intraplacental blood with practically no direct contamination with fetal blood, thus permitting the individualized study of the three compartments, i.e., the maternal, intervillous space and fetal compartments (10). Previous studies have demonstrated that the nutrient concentrations (vitamin E, vitamin B 12 , folate, zinc, and copper) in the three compartments and their interactions vary widely according to the nutrients studied (22)(23)(24)(25). On this basis, the objective of the present study was to assess the amino acid concentrations in the three compartments for a better understanding of maternal-fetal relations.…”

Section: Discussionmentioning

confidence: 96%

Plasma amino acids in pregnancy, placental intervillous space and preterm newborn infants

Camelo

Martinez

Gonçalves

et al. 2007

Braz J Med Biol Res

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Plasma amino acid levels have never been studied in the placental intervillous space of preterm gestations. Our objective was to determine the possible relationship between plasma amino acids of maternal venous blood (M), of the placental intervillous space (PIVS) and of the umbilical vein (UV) of preterm newborn infants. Plasma amino acid levels were analyzed by ion-exchange chromatography in M from 14 parturients and in the PIVS and UV of their preterm newborn infants. Mean gestational age was 34 ± 2 weeks, weight = 1827 ± 510 g, and all newborns were considered adequate for gestational age. The mean Apgar score was 8 and 9 at the first and fifth minutes. Plasma amino acid values were significantly lower in M than in PIVS (166%), except for aminobutyric acid. On average, plasma amino acid levels were significantly higher in UV than in M (107%) and were closer to PIVS than to M values, except for cystine and aminobutyric acid (P < 0.05). Comparison of the mean plasma amino acid concentrations in the UV of preterm to those of term newborn infants previously studied by our group showed no significant difference, except for proline (P < 0.05), preterm > term. These data suggest that the mechanisms of active amino acid transport are centralized in the syncytiotrophoblast, with their passage to the fetus being an active bidirectional process with asymmetric efflux. PIVS could be a reserve amino acid space for the protection of the fetal compartment from inadequate maternal amino acid variations. Correspondence

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“…This is in accordance with some previous studies [19,20], but other investigators have failed to demonstrate a RBC folate deficiency in moth ers of NTD fetuses [12,18]. In the latter stud ies, negative results may have been due to the small number of cases [18], the use of immu nologic rather than biologic folate assays, or the fact that some NTD mothers were sam pled in the postpartum period and had re ceived folate supplements after delivery [12], Because maternal folate levels tend to de crease throughout gestation [21], matching cases with controls of similar gestational age is also likely to have improved the sensitivity of our study. A minor decrease in maternal se rum folate was also observed in our study in the NTD group, but this did not reach statisti cal significance, probably due to the small number of cases.…”

Section: Discussionmentioning

confidence: 99%

Maternal-Fetal Folate Status and Neural Tube Defects: A Case Control Study

Bunduki

Dommergues²,

Zittoun³

et al. 1995

Neonatology

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The object of this study was to explore the role of folate in the pathophysiology of neural tube defects (NTD). Maternal and fetal serum and red blood cell folate were assayed in 14 cases of NTDs and compared with 14 controls with other malformations and matched for gestational age (range 18–36 weeks). In mothers of NTD fetuses, serum folate (5.2 ng/ml), red blood cell folate (294 ng/ml) and the folate methylation rate (65%) were significantly lower than in controls (6.6 and 399 ng/ml, respectively, and 77%). However, the fetal folate status was similar in cases and controls. In the NTD group, folate metabolism was altered in the mothers but not in the fetuses. Therefore, a normal folate placental transfer can be assumed in this group. In addition, it could be speculated that decreased maternal folate methylation might be involved in the pathogenesis of NTDs.

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Serum and red blood cell folate levels in parturients, in the intervillous space of the placenta and in full-term newborns

Cited by 34 publications

References 8 publications

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues

Plasma amino acids in pregnancy, placental intervillous space and preterm newborn infants

Maternal-Fetal Folate Status and Neural Tube Defects: A Case Control Study

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