Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

Ogawa, Takahiro; Hoekstra, Sven P.; Kamijo, Yoshi‐ichiro; Goosey‐Tolfrey, Victoria L.; Walsh, Jeremy J.; F., Fumihiro Tajima; Leicht, Christof A.

doi:10.1371/journal.pone.0260775

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Thermoneutral head-out water immersion has garnered attention as a potential modality to induce elevations in cerebral blood flow (CBF). It is speculated that episodic increases in CBF and potentially shear stress, which augments endothelial-derived nitric oxide bioavailability [1] and brain-derived neurotrophic factor [2][3][4], may contribute to improved cerebrovascular health [5,6]. During thermoneutral water immersion, CBF increases via immersion-induced elevations in arterial CO 2 and blood pressure secondary to the hydrostatic pressure placed on the body [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cool head-out water immersion does not alter cerebrovascular reactivity to hypercapnia despite elevated middle cerebral artery blood velocity: A pilot study

Worley,

Reed,

Klaes

et al. 2024

PLoS ONE

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Episodic increases in cerebral blood flow (CBF) are thought to contribute to improved cerebrovascular function and health. Head-out water immersion (HOWI) may be a useful modality to increase CBF secondary to the hydrostatic pressure placed on the body. However, it is unclear whether water temperatures common to the general public elicit similar cerebrovascular responses. We tested the hypothesis that mean middle cerebral artery blood velocity (MCAvmean) and cerebrovascular reactivity to CO2 (CVRCO2) would be higher during an acute bout of thermoneutral (TN; 35°C) vs. cool (COOL; 25°C) HOWI. Ten healthy participants (age: 23±3 y; 4 women) completed two randomized HOWI visits. Right MCAvmean, end-tidal CO2 (PETCO2) mean arterial pressure (MAP), and MCA conductance (MCAvmean/MAP) were continuously recorded. CVRCO2 was assessed using a stepped hypercapnia protocol before (PRE), at 30 minutes of HOWI (HOWI), immediately after HOWI (POST-1), and 45 minutes after HOWI (POST-2). Absolute values are reported as mean ± SD. MCAvmean, PETCO2, MAP, and CVRCO2 were not different between conditions at any timepoint (all P≥0.17). In COOL, MCAvmean increased from PRE (61±9 cm/s) during HOWI (68±11 cm/s), at POST-1 (69±11 cm/s), and POST-2 (72±8 cm/s) (all P<0.01), and in TN from PRE to POST-1 (66±13 vs. 71±14 cm/s; P = 0.05). PETCO2 did not change over time in either condition. In COOL, MAP increased from PRE (85±5 mmHg) during HOWI (101±4 mmHg), at POST-1 (97±7 mmHg), and POST-2 (96±9 mmHg), and in TN from PRE (88±5 mmHg) at HOWI (98±7 mmHg) and POST-1 (99±8 mmHg) (all P<0.01). In COOL, CVRCO2 increased from PRE to HOWI (1.66±0.55 vs. 1.92±0.52 cm/s/mmHg; P = 0.04). MCA conductance was not different between or within conditions. These data indicate that 30 minutes of cool HOWI augments MCAvmean and that the increase in MCAvmean persists beyond cool HOWI. However, cool HOWI does not alter CVRCO2 in healthy young adults.

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Section: Introductionmentioning

confidence: 99%

Cool head-out water immersion does not alter cerebrovascular reactivity to hypercapnia despite elevated middle cerebral artery blood velocity: A pilot study

Worley,

Reed,

Klaes

et al. 2024

PLoS ONE

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Brain-derived neurotrophic factor in older adults exposed to simulated indoor overheating

Kirby,

Meade,

McCormick

et al. 2024

Eur J Appl Physiol

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The relationships between environmental parameters in livestock pen and physiological parameters of Holstein dairy cows

Nohara

Hisaeda

Ono

et al. 2022

The Journal of Veterinary Medical Science

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There has been an increase in temperature and the incidence of extreme weather events, such as heat wave, due to global warming, which has promoted the incidence of livestock diseases. Therefore, it is important to examine the effect of changes in environmental parameters on livestock performance. The aim of this study was to examine the relationship between ambient environmental conditions in livestock pen and the physiological parameters of Holstein dairy cows. The results showed that there was a decrease in the red blood cell counts, hemoglobin concentrations, and mean corpuscular hemoglobin concentration of the cows with increasing pen temperature, wet bulb globe temperature (WBGT), and temperature humidity index (THI). Additionally, high daily variation in temperature caused a decrease in the serum albumin levels of the cows. Moreover, the lowest serum calcium, inorganic phosphorus, and magnesium concentrations were observed in November, and were negatively correlated with the 24 -hr temperature, WBGT, and THI range of the pen prior to sampling. Multiple regression analysis showed a positive correlation between serum cortisol concentration and 24 -hr WBGT range of the pen prior to samplings and packed cell volume. However, serum cortisol and total protein c oncentrations were negatively correlated. Overall, the findings of the study suggest that large variation in temperature induced stress in the cows, which could be overcome by increased water consumption and improved protein digestion and absorption by the animals, and the addition of minerals, such as calcium to the diet. KEY WORD blood examination values, cortisol, Holstein dairy cows, temperature humidity index , wet bulb globe temperature .

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Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

Cited by 3 publications

References 46 publications

Cool head-out water immersion does not alter cerebrovascular reactivity to hypercapnia despite elevated middle cerebral artery blood velocity: A pilot study

Cool head-out water immersion does not alter cerebrovascular reactivity to hypercapnia despite elevated middle cerebral artery blood velocity: A pilot study

Brain-derived neurotrophic factor in older adults exposed to simulated indoor overheating

The relationships between environmental parameters in livestock pen and physiological parameters of Holstein dairy cows

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