Serum and plasma BDNF levels in major depression: A replication study and meta-analyses

Bocchio-Chiavetto, Luisella; Bagnardi, Vincenzo; Zanardini, Roberta; Molteni, Raffaella; Nielsen, Maria Gabriela; Placentino, Anna; Giovannini, C; Rillosi, Luciana; Ventriglia, Mariacarla; Riva, Marco A.; Gennarelli, Massimo

doi:10.3109/15622971003611319

Cited by 375 publications

(214 citation statements)

References 53 publications

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“…Upregulation of BDNF is observed after chronic, but not acute, administration of different classes of antidepressants, including 5-hydroxytryptamine (5-HT) and norepinephrine-selective reuptake inhibitors. There is also evidence that antidepressant treatment increases BDNF in post-mortem brains of subjects on antidepressants at the time of death, as well as increasing blood levels of patients as discussed earlier [6,9,10].…”

Section: Neurobiology Of Depression: Atrophy and Loss Of Neuronsmentioning

confidence: 99%

“…Post-mortem studies also demonstrate a reduction of BDNF in these regions in post-mortem brains of depressed subjects [6]. This work has led to studies of growth factors in blood, which demonstrate decreased levels of BDNF in serum of depressed patients and reversal with antidepressant treatment, suggesting that BDNF is a biomarker of depression and treatment response [9,10]. In contrast to stress and depression, antidepressant treatment increases the expression of BDNF in the hippocampus and PFC [6,8].…”

Section: Neurobiology Of Depression: Atrophy and Loss Of Neuronsmentioning

confidence: 99%

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A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

Duman

2012

Phil. Trans. R. Soc. B

278

182

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Molecular and cellular studies have demonstrated opposing actions of stress and antidepressant treatment on the expression of neurotrophic factors, particularly brain-derived neurotrophic factor, in limbic structures of the brain. These changes in neurotrophic factor expression and function result in structural alterations, including regulation of neurogenesis, dendrite length and spine density in hippocampus and prefrontal cortex (PFC). The deleterious effects of stress could contribute to the reduced volume of these brain regions in depressed patients. Conversely, the actions of antidepressant treatment could be mediated in part by blocking or reversing the atrophy caused by stress and depression. Recent studies have identified a novel, rapid-acting antidepressant, ketamine, in treatment-resistant depressed patients that addresses the limitations of currently available agents (i.e. delayed onset of action and low response rates). We have found that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, causes a rapid induction of synaptogenesis and spine formation in the PFC via stimulation of the mammalian target of the rapamycin signalling pathway and increased synthesis of synaptic proteins. These effects of ketamine rapidly reverse the atrophy of PFC neurons caused by chronic stress and correspond to rapid behavioural actions of ketamine in models of depression. Characterization of a novel signalling pathway also identifies new cellular targets that could result in rapid and efficacious antidepressant actions without the side effects of ketamine.

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Section: Neurobiology Of Depression: Atrophy and Loss Of Neuronsmentioning

confidence: 99%

Section: Neurobiology Of Depression: Atrophy and Loss Of Neuronsmentioning

confidence: 99%

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

Duman

2012

Phil. Trans. R. Soc. B

278

182

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“…89 Furthermore, BDNF expression is reduced in the PFC, hippocampus 90 and in peripheral tissues of depressed patients, 91 and is involved in the molecular events regulating long-term potentiation. 92 Indeed, a well-studied polymorphism in the BDNF gene, which effectively reduces its protein levels, is related to reduced episodic memory and executive function and decreased hippocampal size in humans.…”

mentioning

confidence: 99%

A role for activity‐dependent epigenetics in the development and treatment of major depressive disorder

Nagy

Vaillancourt

Turecki

2018

Genes Brain and Behavior

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Chronic stressors, during developmental sensitive periods and beyond, contribute to the risk of developing psychiatric conditions, including major depressive disorder (MDD). Epigenetic mechanisms including DNA methylation and histone modifications, at key stress response and neurotrophin genes, are increasingly implicated in mediating this risk. Although the exact mechanisms through which stressful environmental stimuli alter the epigenome are still unclear, research from the learning and memory fields indicates that epigenomic marks can be altered, at least in part, through calcium-dependent signaling cascades in direct response to neuronal activity. In this review, we highlight key findings from the stress, MDD, and learning and memory fields to propose a model where stress regulates downstream cellular functioning through activity-dependent epigenetic changes. Furthermore, we suggest that both typical and novel antidepressant treatments may exert positive influence through similar, activity-dependent pathways.

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“…Diversos estudios han encontrado la relación entre depresión posparto y gestación no deseada (17)(18)(19) . El efecto perjudicial de esta vivencia de embarazo no deseado llevado a término por condiciones del entorno persiste por muchos años (17) .…”

Section: El Embarazo No Deseado Un Factor De Riesgo Para Depresiónunclassified

“…Se trata de una proteína implicada en el crecimiento neuronal, la plasticidad de las sinapsis y en la neurogénesis. Se ha encontrado que las concentraciones en sangre periférica de BDNF se encuentran reducidas en sujetos deprimidos y que se normalizan luego del tratamiento antidepresivo (19) .…”

Section: El Embarazo No Deseado Un Factor De Riesgo Para Depresiónunclassified

Salud mental y aborto terapéutico

Rondón

2016

An Fac med

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ResumenSe revisa el concepto de salud para argumentar que el componente mental es inherente al bienestar integral, estando la salud mental y la física íntimamente interrelacionadas. Se describe la relación entre depresión y eventos del ciclo reproductivo, especialmente en cuanto al riesgo que supone el embarazo no deseado, que es un factor de riesgo para depresión posparto reportado en investigaciones realizadas en diversos lugares del mundo. Siendo así, las mujeres que presentan factores de riesgo para depresión (historia de padecimiento depresivo previo, antecedentes de adversidad o trauma en la infancia o exposición a la violencia, la historia familiar de trastorno afectivo, pobreza y falta de soporte social, enfermedades físicas concomitantes, y la mala salud del feto) deben recibir la información suficiente que les permita decidir si desean interrumpir la gestación por indicación terapéutica para proteger su salud mental. Se ofrecen recomendaciones prácticas para el reconocimiento y manejo de estas mujeres. Palabras clave. Salud mental; Embarazo no Deseado; Depresión. Abstract The concept of health is reviewed to argue that the mental component as inherent to the integral wellbeing, since mental and physical health are closely related. The relationship between depression and events of the reproductive cycle is described, especially concerning the risk posed by unwanted pregnancy, a risk factor for postpartum depression as reported in studies conducted in various parts of the world. Consequently, women with depression risk factors (history of previous depressive ailment, background of infant adversity or trauma or exposition to violence, family history of affective disorder, poverty and lack of social support, concomitant physical ailments, and altered fetus health) should receive information to allow them to decide if they wish to interrupt pregnancy for therapeutic reasons in order to protect their mental health. Practical recommendations to recognize and manage these women are presented. INTRODUCCIÓNLa definición de salud consagrada por la OMS (un estado de bienestar físico, psíquico y social y no la mera ausencia de enfermedad) integra los aspectos biológicos, sicológicos y sociales del bienestar y permite afirmar, como lo hace la Convención para la Eliminación de todas las Formas de Discriminación contra las Mujeres, que las mujeres tienen el derecho a gozar del más alto nivel disponible de salud física y mental. En ese sentido, la protección de la salud de las mujeres proporcionada por los instrumentos que garantizan el acceso al aborto por indicación terapéutica debe incluir la protección de la salud mental.La OMS ha definido la salud mental como el estado de bienestar que permite a cada individuo realizar su potencial, enfrentarse a las dificultades usuales de la vida, trabajar productiva y fructíferamente y contribuir con su comunidad (1) .Este concepto tiene, por cierto, un propósito didáctico para facilitar la capacitación y los procesos de prestación de servicios, al hacer referencia a una dimen...

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Serum and plasma BDNF levels in major depression: A replication study and meta-analyses

Abstract: In conclusion, our results provide evidence of peripheral BDNF alteration in MD and support the rationale for further investigation aiming to the identification of biomarkers for differential diagnosis and personalization of therapies in this disorder.

Cited by 375 publications

References 53 publications

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

A role for activity‐dependent epigenetics in the development and treatment of major depressive disorder

Salud mental y aborto terapéutico

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