Serum and Muscle 1H NMR-Based Metabolomics Profiles Reveal Metabolic Changes Influenced by a Maternal Leucine-Rich Diet in Tumor-Bearing Adult Offspring Rats

Miyaguti, Natália Angelo da Silva; Stanisić, Danijela; Oliveira, Sarah Christine Pereira de; Santos, Gabriela Sales dos; Manhe, Beatriz Schincariol; Tasić, Ljubica; Marcondes, Maria Cristina Cintra Gomes

doi:10.3390/nu12072106

Cited by 6 publications

(5 citation statements)

References 48 publications

(62 reference statements)

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“…The tumor-bearing rats displayed distinctly altered metabolic pathways including protein biosynthesis, glycine, serine and threonine metabolism, and ammonia recycling. Significantly, the leucine-rich diet rats showed attenuated Warburg effect and improved lipid metabolism (Miyaguti et al, 2020).…”

Section: Therapeutic Strategies By Using Metabolomicsmentioning

confidence: 94%

Metabolomics and its Applications in Cancer Cachexia

Cui

Huang

et al. 2022

Front. Mol. Biosci.

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Cancer cachexia (CC) is a complicated metabolic derangement and muscle wasting syndrome, affecting 50–80% cancer patients. So far, molecular mechanisms underlying CC remain elusive. Metabolomics techniques have been used to study metabolic shifts including changes of metabolite concentrations and disturbed metabolic pathways in the progression of CC, and expand further fundamental understanding of muscle loss. In this article, we aim to review the research progress and applications of metabolomics on CC in the past decade, and provide a theoretical basis for the study of prediction, early diagnosis, and therapy of CC.

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Section: Therapeutic Strategies By Using Metabolomicsmentioning

confidence: 94%

Metabolomics and its Applications in Cancer Cachexia

Cui

Huang

et al. 2022

Front. Mol. Biosci.

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“…The fecal and serum metabolites of rats were identified based on the chemical shifts and signal diversity of each metabolite, combined with coupling information from the public database BMRB 2 and 2D NMR profiles from authentic literature (32,(40)(41)(42). Forty-three metabolites were detected in rat feces (Figure 3A), and forty were detected in rat serum (Figure 3B).…”

Section: Nuclear Magnetic Resonance Metabolic Profile Of Rat Feces An...mentioning

confidence: 99%

Effect of dietary protein content shift on aging in elderly rats by comprehensive quantitative score and metabolomics analysis

Zheng

Li²,

Zhou³

et al. 2022

Front. Nutr.

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In the protein nutrition strategy of middle-aged and elderly people, some believe that low protein is good for health, while others believe high protein is good for health. Facing the contradictory situation, the following hypothesis is proposed. There is a process of change from lower to higher ratio of protein nutritional requirements that are good for health in the human body after about 50 years of age, and the age at which the switch occurs is around 65 years of age. Hence, in this study, 50, 25-month-old male rats were randomly divided into five groups: Control (basal diet), LP (low-protein diet with a 30% decrease in protein content compared to the basal diet), HP (high-protein diet with a 30% increase in protein content compared to the basal diet), Model 1 (switched from LP to HP feed at week 4), and Model 2 (switched from LP to HP feed at week 7). After a total of 10 weeks intervention, the liver and serum samples were examined for aging-related indicators, and a newly comprehensive quantitative score was generated using principal component analysis (PCA). The effects of the five protein nutritional modalities were quantified in descending order: Model 1 > HP > LP > Control > Model 2. Furthermore, the differential metabolites in serum and feces were determined by orthogonal partial least squares discriminant analysis, and 15 differential metabolites, significantly associated with protein intake, were identified by Spearman’s correlation analysis (p < 0.05). Among the fecal metabolites, 10 were positively correlated and 3 were negatively correlated. In the serum, tyrosine and lactate levels were positively correlated, and acetate levels were negatively correlated. MetaboAnalyst analysis identified that the metabolic pathways influenced by protein intake were mainly related to amino acid and carbohydrate metabolism. The results of metabolomic analysis elucidate the mechanisms underlying the preceding effects to some degree. These efforts not only contribute to a unified protein nutrition strategy but also positively impact the building of a wiser approach to protein nutrition, thereby helping middle-aged and older populations achieve healthy aging.

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“…These epigenetic effects were also found in morphometric parameters, such as food intake, triglycerides, and serum levels of albumin and globulin. This led to the maintenance of the gastrocnemius muscle due to the upregulation of the mTOR activity [ 129 , 130 , 131 ]. Thus, leucine has been demonstrated to be a potential co-adjuvant therapy in animal models.…”

Section: Leucine-rich Diet As a Potential Treatmentmentioning

confidence: 99%

Pregnancy and Cancer: Cellular Biology and Mechanisms Affecting the Placenta

Oliveira

Salgado

Viana

et al. 2021

Cancers

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Cancer during pregnancy is rarely studied due to its low incidence (1:1000). However, as a result of different sociocultural and economic changes, women are postponing pregnancy, so the number of pregnant women with cancer has been increasing in recent years. The importance of studying cancer during pregnancy is not only based on maternal and foetal prognosis, but also on the evolutionary mechanisms of the cell biology of trophoblasts and neoplastic cells, which point out similarities between and suggest new fields for the study of cancer. Moreover, the magnitude of how cancer factors can affect trophoblastic cells, and vice versa, in altering the foetus’s nutrition and health is still a subject to be understood. In this context, the objective of this narrative review was to show that some researchers point out the importance of supplementing branched-chain amino acids, especially leucine, in experimental models of pregnancy associated with women with cancer. A leucine-rich diet may be an interesting strategy to preserve physiological placenta metabolism for protecting the mother and foetus from the harmful effects of cancer during pregnancy.

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Serum and Muscle 1H NMR-Based Metabolomics Profiles Reveal Metabolic Changes Influenced by a Maternal Leucine-Rich Diet in Tumor-Bearing Adult Offspring Rats

Cited by 6 publications

References 48 publications

Metabolomics and its Applications in Cancer Cachexia

Metabolomics and its Applications in Cancer Cachexia

Effect of dietary protein content shift on aging in elderly rats by comprehensive quantitative score and metabolomics analysis

Pregnancy and Cancer: Cellular Biology and Mechanisms Affecting the Placenta

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