Serum- and glucocorticoid-inducible kinase 3 is a potential oncogene in nasopharyngeal carcinoma

Chen, Jing; Li, Hai Liang; Li, Bo Bo; Li, Wei; Ma, Dong; Li, Yong He; Liu, Tao

doi:10.1016/j.bjorl.2018.05.012

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…The pathophysiology behind the association between stressful events and cancer is attributed to the release of glucocorticoids through the hypothalamic-pituitary axis molecular pathways and in beta-adrenergic signaling through the sympathetic nervous system [28,32]. The release of catecholamines can stimulate the transcription of various proteins involved in the regulation of cellular growth, differentiation and the transcription of various genes, which can result in the onset and progression of various malignancies [33][34][35]. The role of cortisol in tumor cell proliferation has also been described in various malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…The role of glucocorticoid-activated receptors in cell growth and survival has been described in various studies [17,33]. For example, glucocorticoid-inducible kinase 3 has been described as a potential oncogene in nasopharyngeal carcinoma [34]. A few studies have shown the impact of circulating catecholamines and glucocorticoid levels in oral cancer: that chronic stress is associated with increased IL-6 expression in humans with oral cancer and increased VEGF expression with tumor size in oral carcinoma mouse models via increased circulating catecholamines and glucocorticoids [18,35].…”

Section: Discussionmentioning

confidence: 99%

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Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case–Control Study

Sridhar,

Sekhon,

Nguyen

et al. 2024

Cancers

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Background: Major stressful life events have been shown to be associated with an increased risk of lung cancer, breast cancer and the development of various chronic illnesses. The stress response generated by our body results in a variety of physiological and metabolic changes which can affect the immune system and have been shown to be associated with tumor progression. In this study, we aim to determine if major stressful life events are associated with the incidence of head and neck or pancreatic cancer (HNPC). Methods: This is a matched case–control study. Cases (CAs) were HNPC patients diagnosed within the previous 12 months. Controls (COs) were patients without a prior history of malignancy. Basic demographic data information on major stressful life events was collected using the modified Holmes–Rahe stress scale. A total sample of 280 was needed (79 cases, 201 controls) to achieve at least 80% power to detect odds ratios (ORs) of 2.00 or higher at the 5% level of significance. Results: From 1 January 2018 to 31 August 2021, 280 patients were enrolled (CA = 79, CO = 201) in this study. In a multivariable logistic regression analysis after controlling for potential confounding variables (including sex, age, race, education, marital status, smoking history), there was no difference between the lifetime prevalence of major stressful event in cases and controls. However, patients with HNPC were significantly more likely to report a major stressful life event within the preceding 5 years when compared to COs (p = 0.01, OR = 2.32, 95% CI, 1.18–4.54). Conclusions: Patients with head, neck and pancreatic cancers are significantly associated with having a major stressful life event within 5 years of their diagnosis. This study highlights the potential need to recognize stressful life events as risk factors for developing malignancies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case–Control Study

Sridhar,

Sekhon,

Nguyen

et al. 2024

Cancers

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“…SGK3 silencing could suppress proliferation, survival and migration of NPC cells (Chen et al, 2019).…”

Section: Sgk3mentioning

confidence: 98%

The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma

Lao

Quang

2021

Asian Pac J Cancer Prev

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Objective: MicroRNAs (miRNAs) are key post-transcriptional regulators of protein translation in humans. They have an essential role in various cancers, including nasopharyngeal carcinoma (NPC). The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets. This study provides a systematic view of the roles of miR-21 and its network of targets (hsa-miR-21-3p, hsa-miR-21-5p) that are associated with nasopharyngeal carcinoma. Methods: Bioinformatics tools were applied to predict the targets of miR-21. Interactions among the targets of hsa-miR-21-3p/5p were found by the gene MANIA online tool. Results and conclusion: It was found that the target genes are involved in vital biological processes in cancer. In detail, a total of 95 targets of miR-21 were recorded to be associated with NPC. Therefore, they may provide new insights into nasopharyngeal pathogenesis and bring about novel targets for NPC diagnosis as well as therapy in near future.

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“…Laser-based therapies, particularly photothermal therapy (PTT), have emerged as promising strategies for this purpose. [1][2][3][4] These therapies utilize agents with near-infrared (NIR) activity to absorb laser energy and convert it into heat, thereby inducing localized thermal damage, specifically to cancer cells. 5,6 By harnessing the power of PTT, it is possible to mitigate the toxic side effects associated with traditional chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

Wang,

Cheng,

Xing

et al. 2024

J. Mater. Chem. B

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Serum- and glucocorticoid-inducible kinase 3 is a potential oncogene in nasopharyngeal carcinoma

Cited by 6 publications

References 38 publications

Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case–Control Study

Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case–Control Study

The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

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