Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes

Cai, Yun Ying; Lin, Na; Zhong, Lan Ping; Duan, Hui; Dong, Yun; Wu, Ze; Su, Heng

doi:10.1186/s12958-019-0529-0

Cited by 29 publications

(26 citation statements)

References 35 publications

(35 reference statements)

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“…Some genes regulate hormone levels, including gonadotropin-releasing hormone (GNRH), oxytocin (OXT), growth hormone (GH), and thyroid hormone (TH). All these hormones play a vital role in the female reproductive system [41][42][43][44][45][46]. Some genes affect egg number traits by affecting the growth and development of follicles.…”

Section: Candidate Genesmentioning

confidence: 99%

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

et al. 2021

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Background Since the domestication of chicken, various breeds have been developed for food production, entertainment, and so on. Compared to indigenous chicken breeds which generally do not show elite production performance, commercial breeds or lines are selected intensely for meat or egg production. In the present study, in order to understand the molecular mechanisms underlying the dramatic differences of egg number between commercial egg-type chickens and indigenous chickens, we performed a genome-wide association study (GWAS) in a mixed linear model. Results We obtained 148 single nucleotide polymorphisms (SNPs) associated with egg number traits (57 significantly, 91 suggestively). Among them, 4 SNPs overlapped with previously reported quantitative trait loci (QTL), including 2 for egg production and 2 for reproductive traits. Furthermore, we identified 32 candidate genes based on the function of the screened genes. These genes were found to be mainly involved in regulating hormones, playing a role in the formation, growth, and development of follicles, and in the development of the reproductive system. Some genes such as NELL2 (neural EGFL like 2), KITLG (KIT ligand), GHRHR (Growth hormone releasing hormone receptor), NCOA1 (Nuclear receptor coactivator 1), ITPR1 (inositol 1, 4, 5-trisphosphate receptor type 1), GAMT (guanidinoacetate N-methyltransferase), and CAMK4 (calcium/calmodulin-dependent protein kinase IV) deserve our attention and further study since they have been reported to be closely related to egg production, egg number and reproductive traits. In addition, the most significant genomic region obtained in this study was located at 48.61–48.84 Mb on GGA5. In this region, we have repeatedly identified four genes, in which YY1 (YY1 transcription factor) and WDR25 (WD repeat domain 25) have been shown to be related to oocytes and reproductive tissues, respectively, which implies that this region may be a candidate region underlying egg number traits. Conclusion Our study utilized the genomic information from various chicken breeds or populations differed in the average annual egg number to understand the molecular genetic mechanisms involved in egg number traits. We identified a series of SNPs, candidate genes, or genomic regions that associated with egg number, which could help us in developing the egg production trait in chickens.

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Section: Candidate Genesmentioning

confidence: 99%

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

et al. 2021

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“…On the other hand, in the study by Cai et al, implantation failure was associated with lower FT4 levels but not with the presence of thyroid antibodies in the serum or FF (11), leading the authors to conclude that thyroid function might be more important than that of TAI. In the study by Zhong et al lower implantation rates were present in women with TAI (64% vs 74% in women without TAI), but the authors did not determine TSH in their study, rendering the further interpretation of the results difficult (78).…”

Section: Thyroid Disorders and Art (Ivf/icsi) Clinical Outcomesmentioning

confidence: 91%

“…TH may reduce granulosa cell aromatase activity, impair pre-antral follicle development, and regulate ovarian function, in part via its effects on nitric oxide synthase (8). Thyroid receptors (T3-r and TSH-r) are present on the developing and mature oocyte and T3, T4 and thyroid antibodies are present in the follicular fluid (9,10,11).…”

Section: Introductionmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Thyroid and female infertility: more questions than answers?!

Poppe

2021

European Journal of Endocrinology

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Severe thyroid dysfunction may lead to menstrual disorders and infertility via direct and indirect interactions with the hypothalamo-pituitary-ovarian axis and the reproductive organs. However, the precise prevalence of infertility in women with thyroid disorders remains unknown. Fertility problems may persist even after restoring normal thyroid function, and then surgery and/or an assisted reproductive technology (ART) may be necessary to obtain a pregnancy. The initial step in an ART treatment is the ovarian stimulation, putting strain on the thyroid gland, potentially leading to (permanent) hypothyroidism in women with thyroid autoimmunity (TAI) or when already treated with thyroid hormones (LT4). Moreover, women with ovarian and unexplained causes of infertility have a higher prevalence of TAI. In women treated with LT4, a serum TSH level <2.5 mIU/L should be targeted before ART. In women with TSH levels >4.0 mIU/L, fertilisation rates, embryo quality and live birth rates may be impaired and improved with LT4 therapy. In euthyroid women with TAI, LT4 should not be given systematically, but on a case-by-case basis if serum TSH is >2.5 mIU/L. For all of the above reasons, women of infertile couples should be screened routinely for the presence of thyroid disorders. In this review, we will focus on the gaps in the current knowledge, the remaining questions on the associations between thyroid (disorders) and (assisted) reproduction and make proposals for future investigations that may lead to a better understanding and contribute to novel treatment options in the long term.

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“…Some genes regulate hormone levels, including gonadotropin-releasing hormone (GNRH), oxytocin (OXT), growth hormone (GH), and thyroid hormone (TH). All these hormones play a vital role in the female reproductive system [40][41][42][43][44][45]. Some genes affect egg production traits by affecting the growth and development of follicles.…”

Section: Candidate Genesmentioning

confidence: 99%

Identification of Candidate Genomic Regions for Chicken Egg Production Traits Based on Genome Wide Association Study

Zhao

Nie

Zhang

et al. 2021

Preprint

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Background: Since the domestication of chicken, various chicken breeds have been developed for food production, entertainment, and so on. Compared to indigenous chicken breeds which generally do not show elite production performance, commercial breeds or lines are selected intensely for meat or egg production. In the present study, in order to understand the molecular mechanisms underlying the dramatic egg yielding differences between commercial egg-type chickens and indigenous chickens, we performed a genome-wide association study (GWAS) in a mixed linear model. Results: We obtained 148 single nucleotide polymorphisms (SNPs) associated with egg production traits or reproductive traits (57 significantly, 91 suggestively). Among them, 18 SNPs overlapped with previously reported quantitative trait loci (QTL), including 13 for egg production and 5 for reproductive traits. Three SNPs were significantly associated with multiple egg production traits, such as egg number, age at first egg, and egg production rate in chickens. Furthermore, we identified 32 candidate genes based on the function of the screened genes. These genes were found to be mainly involved in regulating hormones, playing a role in the formation, growth, and development of follicles, and in the development of the reproductive system. Some genes such as NELL2, KITLG, GHRHR, NCOA1, ITPR1, GAMT, and CAMK4 deserve our attention and further study since they have been reported to be closely related to reproductive traits. In addition, the most significant genomic region obtained in this study was located at 48.61-48.84Mb on GGA5. In this region, we have repeatedly annotated four genes, in which YY1 and WDR25 have been shown to be related to oocytes and reproductive tissues, respectively, which implies that this region may be a candidate region underlying egg production traits. Conclusion: Our study utilized the genomic information from various chicken breeds or populations differed in egg production to understand the molecular genetic mechanisms involved in reproduction traits. We identified a series of SNPs, candidate genes, or genomic regions that associated with reproductive traits, which could help us in developing egg production in chickens.

show abstract

Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes

Cited by 29 publications

References 35 publications

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study

MANAGEMENT OF ENDOCRINE DISEASE: Thyroid and female infertility: more questions than answers?!

Identification of Candidate Genomic Regions for Chicken Egg Production Traits Based on Genome Wide Association Study

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