Serum and ascitic fluid nitrate levels in patients with cirrhosis

Coşkun, Uğur; Özeni̇rler, Seren; Sancak, Banu; Bukan, Neslihan

doi:10.1016/s0009-8981(01)00414-4

Cited by 24 publications

(25 citation statements)

References 25 publications

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“…Previous reports have indicated that nitrate concentration and nitric oxide levels may be raised in ascites from patients with cirrhosis and SBP [14,21] . Since nitric oxide is a diffusible, short-lived, and a reactive free radical gas that is difficult to measure in vivo [22,23] , most studies have based their conclusions on measurement of nitrite and nitrate in biological fluids [24][25][26] .…”

Section: Discussionmentioning

confidence: 93%

“…Intriguingly, reagent strips detecting leukocyte esterase activity in biological fluids have been validated for the diagnosis of urinary tract infections [9,10] , peritonitis in patients on continuous ambulatory peritoneal dialysis [11] , pleural infections [12] and meningitis [13] . The observation that nitrate levels in ascites fluid are raised in patients with SBP is also of interest [14] . Thus far, however, no study has specifically looked at the potential usefulness of nitrite reagent test strips as a diagnostic tool in this patient group.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

Torun

Dolar²,

Yılmaz³

et al. 2007

WJG

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AIM:To investigate the diagnostic efficacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: RESULTS:Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specificity, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically significant effects on diagnostic accuracy. CONCLUSION:Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

Torun

Dolar²,

Yılmaz³

et al. 2007

WJG

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“…It has been demonstrated that there was a significant elevation of both serum nitrite and nitrate in patients with primary biliary cirrhosis but not in hepatitis [10]. Overproduction of NO in cirrhotic patients is related to the severity of liver damage [19]. Battista et al [9] reported that enhanced NO production in primary biliary cirrhosis could be related to the development of a strong inflammation and at least partially to neutrophil activation.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum nitric oxide metabolites in biliary atresia

et al. 2005

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Biliary atresia (BA) remains one of the most intractable liver diseases in children. The aim of this study was to investigate the possible roles of nitric oxide (NO) in BA. Serum levels of nitrite and nitrate (NO production) were determined using a colorimetric method from 65 post-operative BA patients and 12 healthy children. The patients were categorized into two groups according to their jaundice status, and serum alanine aminotransferase (ALT, a marker for liver injury). Unpaired t tests were used. Data are expressed as mean and SD in terms of mumol/l. Age and gender between BA patients and controls were comparable. Serum NO metabolites of BA patients was higher than the controls (79.77+/-21.22 vs. 65.75+/-9.44, P=0.001). Subgroup analysis revealed that there was no difference in serum nitrate/nitrite levels of BA patients without jaundice compared to those with jaundice (78.85+/-23.23 vs. 80.90+/-18.76, P=0.70). However, patients with serum ALT> or =100 IU/l had higher levels of serum NO metabolites compared to those with serum ALT<100 IU/l. In conclusion, NO production was elevated in BA patients compared to normal controls. Serum NO was associated with serum ALT levels, but not with jaundice status, in BA patients. These suggest that NO plays a role in the pathophysiology of liver injury in post-operative BA.

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“…11 Nitric oxide (NO) is a potent biologic molecule of physiologic functions such as vasodilatation, neurotransmission, host defense and carcinogenesis. [12][13][14] NO plays a complex and sometimes opposite role in tumorigenesis. The association between increased NO activity and tumor progression is proposed by some studies, 15,16 whereas others showed a positive correlation with decreased NO activity.…”

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confidence: 99%

Prognostic Value of Serum IL-18 and Nitric Oxide Activity in Breast Cancer Patients at Operable Stage

Günel

Coşkun

Sancak

et al. 2003

American Journal of Clinical Oncology

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Interleukin-18 (IL-18) is a multifunctional cytokine that was previously termed interferon-gamma-inducing factor. It has been suggested that serum IL-18 level may be used as a prognostic factor in some cancer types. Nitric oxide is a potent biologic molecule involved in the pathogenesis of cancer. In this study, we measured serum IL-18 and nitrate + nitrite levels in 56 patients with nonmetastatic breast cancer and 14 control subjects. Serum IL-18* and nitrate + nitrite** levels were significantly higher in patients with breast cancer when compared to the control subjects (*p < 0.05, **p < 0.001). Serum IL-18 levels were significantly higher in patients whose tumor size was greater than or equal to 5 cm when compared to patients whose tumor size was less than or equal to 2 cm (p < 0.05). Patients who were axillary lymph node negative (ALN) had lower serum IL-18 levels when compared to patients with positive ALN (p < 0.001). Serum IL-18 levels were significantly higher in patients with stage IIB or IIIA when compared to patients with stage I or IIA (p < 0.05). There was no significant difference in serum nitrate + nitrite levels in terms of age, tumor stage, estrogen receptor, and menopausal and ALN status (p > 0.05). In conclusion, serum IL-18 level may be a useful marker to predict prognosis of patients with breast cancer in complete remission after surgery. Long-term follow-up is required to clarify this hypothesis.

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Serum and ascitic fluid nitrate levels in patients with cirrhosis

Cited by 24 publications

References 25 publications

Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

Elevated serum nitric oxide metabolites in biliary atresia

Prognostic Value of Serum IL-18 and Nitric Oxide Activity in Breast Cancer Patients at Operable Stage

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