Serum amyloid A protein in acute viral infections.

Miwata, Hiroyuki; Yamada, Toshiyuki; Okada, Minoru; Kudo, Takako; Kimura, Hiroshi; Morishima, Tsuneo

doi:10.1136/adc.68.2.210

Cited by 64 publications

(52 citation statements)

References 22 publications

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“…Among the APPs found in SARS patients, SAA and haptoglobin have been widely used as inflammatory markers for evaluating the status of infection and inflammatory lesions in veterinary medicine (19). Although SAA is not as commonly used in human medicine as C-reactive protein (CRP), it is more sensitive to acute response than CRP (17,20,21).…”

Section: Discussionmentioning

confidence: 99%

“…These proteins may provide a fast and effective control of inflammatory damage until the subsequent defensive mechanisms can begin to operate (15). In the past, there have been very few studies on the response of APPs to bacterial (16) or viral infection (17,18). Among the APPs found in SARS patients, SAA and haptoglobin have been widely used as inflammatory markers for evaluating the status of infection and inflammatory lesions in veterinary medicine (19).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

Chen

Chang

Yao

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

114

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We have investigated the plasma proteome by using 2D gel electrophoresis and MS from patients with severe acute respiratory syndrome (SARS). A complete proteomic analysis was performed on four patients with SARS in different time courses, and a total of 38 differential spots were selected for protein identification. Most of the proteins identified are acute phase proteins, and their presence represents the consequence of serial cascades initiated by SARS-coronavirus infection. There are several proteins that have never been identified in plasma before using 2D gel electrophoresis, among which peroxiredoxin II was chosen for further study by analyzing additional 20 plasma samples from patients with probable and suspected SARS and patients with fever, respectively. The results showed that the level of plasma peroxiredoxin II in patients with SARS is significantly high and could be secreted by T cells. Taken together, our findings indicate that active innate immune responses, along with the oxidation-associated injuries, may play a major role in the pathogenesis of SARS.proteomic techniques ͉ acute phase proteins ͉ peroxiredoxin II S evere acute respiratory syndrome (SARS) was first recognized at the end of 2002 in Guangdong, China, and since then the disease has spread to several countries. By late July 2003, Ͼ8,000 SARS cases and Ͼ700 SARS-related deaths were reported from Ͼ25 countries around the world, and no effective treatment has been established so far. Through extensive studies, the causative agent of SARS has been identified as a human SARS-coronavirus (SARS-CoV) (1-3). Although the complete genome sequence of SARS-CoV, the structure of the main protease (3CL protease), and the possible receptor have been determined (4-7), the pathogenesis of SARS is still not fully understood.Plasma proteins are useful targets for diagnostic, prognostic, and͞or therapeutic development. With proteomic tools available recently, profiling of human plasma proteome becomes more feasible in searching for disease-related markers (8). To explore the possible pathogenetic mechanisms involving the progression of SARS, we have analyzed the plasma proteins of 22 different plasma samples from four SARS patients in different time courses by using 2D gel electrophoresis (2DE) in combination with MS. The results showed that most of the plasma proteins found in patients with SARS are acute phase proteins (APPs) generated by inflammatory reactions during SARS-CoV-induced acute lung injuries. Materials and MethodsHuman Subjects. Four SARS patients with a total of 22 plasma samples were selected for complete proteomic analysis. These patients were infected by SARS-CoV through nosocomial transmission during one major SARS outbreak in one municipal hospital in Taipei. For comparison, plasma samples from six healthy individuals were used as controls. The protein concentration of each sample was determined by the standard Bradford method. The use of these samples was approved by the Review Board of the Tri-Service General Hospital, National Def...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

Chen

Chang

Yao

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

114

View full text Add to dashboard Cite

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“…The usefulness of SAA determination comes from its rapid and exponential increase at the onset of diseases with an inflammatory nature and its rapid decrease with resolution (17,20). The evidence for its clinical value in inflammation and infection due to bacterial, viral and protozoal causes is constantly expanding (3,5,15,16). With this background in mind, the aim of this study was to see how well clinical observations of lactating dairy cattle concur with changes in SAA, a definitive marker of early inflammation.…”

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confidence: 99%

Using serum amyloid a to screen dairy cows for sub‐clinical inflammation

Karreman¹,

Wentink²,

Wensing

2000

Veterinary Quarterly

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“…In neutropenic patients with acute leukemia, for example, SAA enabled a differentiation between infectious and non-infectious febrile episodes [37]. In children with a variety of viral infections, SAA concentrations increased during the acute phase of infection [38]. In a small number of aSAH patients it has also been already proposed as an infection marker [12].…”

Section: Discussionmentioning

confidence: 99%

Infection prediction for aneurysmal subarachnoid hemorrhage patients at hospital admission: combined panel of serum amyloid A and clinical parameters

Azurmendi¹,

Sarrafzadeh²,

Tiberti³

et al. 2017

J Transl Sci

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Purpose: Nosocomial infections are some of the main causes of worsening outcomes and death in aneurysmal subarachnoid hemorrhage patients. We hypothesize that combination of clinical parameters and blood biomarkers could increase the capacity of individual markers to dichotomize the patients at risk of infections. Methods:The present study included 104 patients (69 infected/35 non-infected) from two independent European cohorts. Accuracy of biomarkers (serum amyloid A, C-reactive protein, neopterin and WBC) and clinical parameters (WFNS, GCS and age) were evaluated at hospital admission using receiver operating characteristic curves. The most accurate panel combination was obtained using Panelomix. Results:At hospital admission, the most sensitive parameters for the stratification of patients at risk of developing an infection were SAA and the WFNS. To reach a SP of 100% (95% CI, 100-100), SE values of 26.9% (95% CI, 15.9-38.1) and 31.9% (95% CI, 21.7-43.5) were obtained respectively. Moreover, the combination of SAA, WBC, WFNS, and age significantly improved the SE to 64.3% (95% CI, 50-78.6). Conclusions:At hospital admission the panel SAA, WBC, WFNS, and age appear as a promising tool for predicting in-hospital infections, which could lead to a better management of patients and in their associated outcomes.

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Serum amyloid A protein in acute viral infections.

Cited by 64 publications

References 22 publications

Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

Using serum amyloid a to screen dairy cows for sub‐clinical inflammation

Infection prediction for aneurysmal subarachnoid hemorrhage patients at hospital admission: combined panel of serum amyloid A and clinical parameters

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