Serum Amyloid A Levels Associated with Gastrointestinal Manifestations in Henoch-Schönlein Purpura

He, Xuelian; Zhao, Yulan; Li, Yin; Kang, Shixiu; Ding, Yan; Luan, Jiangwei; Zhao, Peiwei; Liu, Ningsheng

doi:10.1007/s10753-012-9435-8

Cited by 6 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serological reports in IgAV have indicated dysregulated inflammatory cytokine production and elevated acute phase proteins. Namely, increased levels of systemic SAA (36-fold) were previously found in IgAV pediatric patients [18,19] and associated with GIT manifestations [18]. The current report exposes significantly elevated levels of SAA (12-fold) in the sera of adult IgAV patients, indicating a low-medium inflammatory response.…”

Section: Discussionsupporting

confidence: 59%

Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis

et al. 2018

View full text Add to dashboard Cite

Immunoglobulin A vasculitis (IgAV) is an immune complex, small vessel vasculitis with dominant IgA deposits in vessel walls, predominantly affecting the pediatric population. However, adults frequently have more severe gastrointestinal tract (GIT) and renal involvements as compared to children. Our aim was to study serological and cellular biomarkers to support clinicians in their diagnosis and the course of IgAV in adult patients. This cross-sectional study included 62 adult IgAV patients and 53 healthy blood donors (HBDs). Demographic and clinical data, as well as routine laboratory tests, were meticulously analyzed. Serum levels of IL-1β, IL-2, IL-6, IL-8, IL-9, IL-10, IL-17A, IL-23, TNF-α and serum amyloid A (SAA) were measured. Percentages of neutrophils, lymphocytes, and monocytes with neutrophil expression of L-selectin and integrin αM were determined by flow cytometry. SAA (12-fold), IL-6 (3-fold), IL-8 (2-fold), and TNF-α (2-fold) were significantly elevated in sera of adult IgAV patients compared to HBDs. There was a 16% elevation in neutrophils in IgAV patients, with IgAV neutrophils showing significantly higher CD62L surface expression. IgAV patients with GIT involvement exhibited elevated numbers of leukocytes, neutrophils, and neutrophil/lymphocyte (NLR), but lower neutrophil CD11b expression, as compared to IgAV patients without GIT. IgAV patients exhibit a low-medium grade inflammatory, neutrophil-driven response. Patients with GIT can be distinguished by their elevated NLR.

show abstract

Section: Discussionsupporting

confidence: 59%

Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…SAA1 is an acute phase proteins, and it is not surprising that it was increased in patients with active IgAV. Moreover, we also investigated that SAA1 levels were positively correlated with C-reactive protein (CRP) [ 11 ], the most commonly used acute phase protein in clinical practice. C4A and KNG1 were not correlated with CRP, and the elevation in these serum proteins could not only due to systemic acute phase reaction but also contribute to the pathogenesis of IgAV.…”

Section: Resultsmentioning

confidence: 99%

Higher Serum Angiotensinogen Is an Indicator of IgA Vasculitis with Nephritis Revealed by Comparative Proteomes Analysis

Ding

Cui

et al. 2015

PLoS ONE

Self Cite

View full text Add to dashboard Cite

IgA vasculitis (IgAV), previously named as Henoch–Schönlein purpura, is the most common systematic vasculitis with unknown etiology. Lack of appropriate study system and/or animal model limits the understanding of its molecular pathogenesis and hinders the identification of targets for rational therapy, especially for its long-term complication, IgAV nephritis (IgAVN). In this study, we applied comparative analysis of serum proteomes to obtain an insight about disease pathogenesis. This study has utilized high sensitivity nanoscale ultra performance liquid chromatography-mass spectrometry (nanoLC-MS/MS) to investigate the alterations in serum proteomic profiles in patients with IgAV (n=6), IgAVN (n=6) and healthy subjects (n=7). The differentially expressed proteins were subjected to functional pathway analysis by PANTHER and DAVID software. We identified 107 differentially expressed proteins among three different groups, and functional analysis suggested that, in addition to earlier reported pathways, such as acute phase response, immune response, complement and blood coagulation pathways, hemostasis and Wnt signaling pathway were probably involved in pathogenesis of IgAV. A few differentially abundant proteins identified, such as C4a, serum amyloid A, angiotensinogen, and kininogen 1, were further validated by ELISA. More importantly, we found that angiotensinogen concentration is correlated with IgAVN and could be used as a potential marker for the progression of IgAV. This is the first report of analyzing the proteomic alterations in IgAV patients and the differentially proteins identified in this study may enhance understanding of the pathology of IgAV and a few of them may be used to monitor disease progression.

show abstract

“…The association between SAA and RDs was reported in 32 studies (38 group comparators) evaluating a total of 2365 RD patients (mean age 44 years, 69% females) and 1632 healthy controls (mean age 43 years, 66% females) [ 41 – 72 ] (Table 1 ). Eighteen studies were conducted in Asia [ 41 , 42 , 44 – 46 , 48 , 50 , 55 , 57 , 59 – 61 , 65 – 69 , 72 ], six in Europe [ 52 – 54 , 58 , 62 , 64 ], five in America [ 47 , 49 , 51 , 56 , 70 ], two in Africa [ 63 , 71 ], and one in Oceania [ 43 ]. Thirteen study comparators included patients with RA [ 42 , 43 , 47 , 49 , 52 , 55 , 56 , 63 , 65 , 67 , 71 ], five with SLE [ 45 , 46 , 55 , 58 ], five with FMF [ 53 , 57 , 59 , 60 , 66 ], three with Takayasu arteritis (TA) [ 48 , 61 , 69 ], two with AS [ 44 , 68 ], two with SSc [ 54 , 62 ], two with osteoarthritis (OA) [ 52 , 55 ], one with BD [ 41 ], one with Henoch–Schönlein purpura (HSP) [ 50 ], one with spondylarthritis (SpA) [ 5...…”

Section: Resultsmentioning

confidence: 99%

The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis

Zinellu,

Mangoni

2024

Clin Exp Med

View full text Add to dashboard Cite

The identification of novel, robust biomarkers for the diagnosis of rheumatic diseases (RDs) and the presence of active disease might facilitate early treatment and the achievement of favourable long-term outcomes. We conducted a systematic review and meta-analysis of studies investigating the acute phase reactant, serum amyloid A (SAA), in RD patients and healthy controls to appraise its potential as diagnostic biomarker. We searched PubMed, Scopus, and Web of Science from inception to 10 April 2024 for relevant studies. We evaluated the risk of bias and the certainty of evidence using the JBI Critical Appraisal Checklist and GRADE, respectively (PROSPERO registration number: CRD42024537418). In 32 studies selected for analysis, SAA concentrations were significantly higher in RD patients compared to controls (SMD = 1.61, 95% CI 1.24–1.98, p < 0.001) and in RD patients with active disease compared to those in remission (SMD = 2.17, 95% CI 1.21–3.13, p < 0.001). Summary receiving characteristics curve analysis showed a good diagnostic accuracy of SAA for the presence of RDs (area under the curve = 0.81, 95% CI 0.78–0.84). The effect size of the differences in SAA concentrations between RD patients and controls was significantly associated with sex, body mass index, type of RD, and study country. Pending the conduct of prospective studies in different types of RDs, the results of this systematic review and meta-analysis suggest that SAA is a promising biomarker for the diagnosis of RDs and active disease.

show abstract

Serum Amyloid A Levels Associated with Gastrointestinal Manifestations in Henoch-Schönlein Purpura

Cited by 6 publications

References 22 publications

Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis

Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis

Higher Serum Angiotensinogen Is an Indicator of IgA Vasculitis with Nephritis Revealed by Comparative Proteomes Analysis

The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis

Contact Info

Product

Resources

About