Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever

Abstract

Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.

Articular manifestations in Egyptian children with familial Mediterranean fever

“…The most frequent MEFV gene mutations were V726A (24.35%), E148Q (20.87%), M694I (20.43%), M680I (12.61%), M694V (10.43%), and A7445 (3.04%). This is nearly similar to many studies [26,27] while in the study by Mneimneh et al [28], M694V (37.2%) and E148Q (27.4%) were the commonest. These differences may be due to the effect of different genetic backgrounds that affect the genetic pattern of the disease.…”

“…When we analyzed the clinical presentation, we found that abdominal pain was the most common followed by fever, chest pain, and arthritis. This is similar to the results of another Egyptian study [26], while Duşunsel et al [27] reported that fever was the most common followed by abdominal pain. It seems that different genetic patterns of the disease among different populations affect the clinical picture of the attacks.…”

Clinical Implications of S100A12 and Resolvin D1 Serum Levels, and Related Genes in Children with Familial Mediterranean Fever

“…The levels of S100A12 and resolvin D correlated significantly (p < 0.001) with the classical inflammatory biomarkers as 70 (89.7%) patients had high serum amyloid levels, which agree with Lofty et al 28 and Duzova et al 29 Similarly, Ben-Zvi and Livneh 24 affirmed that although the Fig. 3 The ROC curve of S100A12 and resolvin D1 was at a cutoff point of 529.5 pg/mL and 231 pg/mL respectively, their sensitivity was 97.4 and 100%, specificity 80 and 50% respectively and the areas under the curve (AUC) was 0.958 and 0.82 respectively.…”

“…In addition, CRP was elevated in 50 (64.1%) cases higher than the findings of others studies. 28,29,32 The number of patients with increased SAA was more than those with elevated CRP. This may be due to the high sensitivity of SAA in detecting the degree of inflammation.…”

Ergebnisse der systematischen Literatursuche als Grundlage für die „evidenzbasierten Therapieempfehlungen für FMF-Patienten mit unzureichendem Ansprechen bzw. Unverträglichkeit auf Kolchizin“ der Gesellschaft für Kinder- und Jugendrheumatologie und der Deutschen Gesellschaft für Rheumatologie

“…[ 40 ] 2017 Aktive Erkrankung trotz mindestens 3 Monate langer Kolchizin-Therapie Lofty, H.M. et al. [ 41 ] 2016 ≥1 Attacke/Monat Melikoglu, M.A. et al.…”