Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study

Jylhävä, Juulia; Haarala, Atte; Eklund, Carita; Pertovaara, Marja; Kähönen, Mika; Hutri‐Kähönen, Nina; Levula, Mari; Lehtimäki, Terho; Huupponen, Risto; Jula, Antti; Juonala, Markus; Viikari, Jorma; Raitakari, Olli T.; Hurme, Mikko

doi:10.1111/j.1365-2796.2009.02120.x

Cited by 42 publications

(32 citation statements)

References 38 publications

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“…216 Other factors such as white blood cells and serum amyloid A have also emerged as additional downstream markers of inflammation. However, the data are not conclusive 58,108,139,219 and to date have not supplied additional predictive power above that of CRP, IL-6, and TNF-␣.…”

Section: Inflammation Beyond Crpmentioning

confidence: 97%

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal¹,

Ferranti²,

Cook³

et al. 2011

Circulation

295

239

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Abstract-The rapid increase in the prevalence and severity of obesity in children is likely to lower the age of onset and increase the incidence of cardiovascular disease worldwide. Understanding the pathophysiology and improving the clinical management of cardiovascular disease involve a knowledge of novel risk factors and biomarkers. The clinical and mechanistic roles of these novel biological factors during childhood are currently being investigated. The goals of this scientific statement are to present the existing knowledge and theoretical framework of nontraditional risk factors for cardiovascular disease as they relate to children and adolescents, to describe the relevance and weight of available experimental and clinical evidence and the therapeutic implications pertaining to nontraditional risk factors in the pediatric population, and to stimulate further research with a goal of developing valid and reliable approaches to identify and validate novel risk factors that will aid in the clinical evaluation and perhaps prediction of cardiovascular disease in the pediatric population. Although several biomarkers are promising, substantial research is required before nontraditional risk factors can be used to identify and reduce cardiovascular disease risk in children and adolescents. (Circulation. 2011;123:2749-2769.)

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Section: Inflammation Beyond Crpmentioning

confidence: 97%

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal¹,

Ferranti²,

Cook³

et al. 2011

Circulation

295

239

View full text Add to dashboard Cite

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“…Like CRP, serum amyloid A (SAA) is an acute phase protein that is associated with CVD [15,18] but not with subclinical atherosclerosis [19]. Unlike CRP, SAA is mainly produced in adipose tissue under noninflammatory conditions.…”

Section: Original Articlementioning

confidence: 99%

Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study

Haarala

Kähönen

Eklund

et al. 2011

European Journal of Clinical Investigation

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“…Whether or not there is a relationship between age and SAA is inconsistent throughout the literature. Several studies have reported a positive correlation with age in neonates/infants with suspected infections (22) and in healthy adults (37)(38)(39), while others have shown no relationship (40,41). Since the increased SAA concentrations may be affected by numerous clinical factors that we did not adjust for (e.g., developmental variation such as premature vs. full-term infants, the presence or absence of chronic subdural hematoma or other extracranial injuries), further validation studies with increased sample size are needed to understand these potential confounders in the pediatric population.…”

Section: Articles Gao Et Almentioning

confidence: 99%

Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis

et al. 2014

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Background: Abusive head trauma (AHT) is the leading cause of death from traumatic brain injury in infants and young children. Identification of mild AHT (Glasgow Coma Scale score: 13-15) is difficult because children can present with nonspecific symptoms and with no history of trauma. Methods: Two-dimensional difference gel electrophoresis combined with mass spectrometry was used to compare the serum protein profile of children with mild AHT and agematched controls. Protein changes were confirmed by western blots. Western blots were performed using serum from children with mild, moderate, and severe AHT to assess the effect of injury severity on protein intensity. The protein identifiedserum amyloid A (SAA)-was then measured by enzymelinked immunosorbent assay. results: Using serum from 18 mild AHT cases and 20 controls, there were ~1,000 protein spots; 2 were significantly different between groups. Both spots were identified as SAA. There was no relationship between protein levels and injury severity. SAA concentrations measured by enzyme-linked immunosorbent assay were increased in cases vs. controls. conclusion: SAA may be a potential biomarker to identify children with mild AHT who present for medical care without a history of trauma and who might otherwise not be recognized as needing a head computed tomography.

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Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study

Abstract: Abstract. Jylhävä J, Haarala A, Eklund C, Pertovaara

Cited by 42 publications

References 38 publications

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study

Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis

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