Serum Amyloid A as an Inflammation Marker in Lichen Planus

Abstract

Inviting Innovations to tissue damage and degradation and eventually can lead to the development of secondary amyloidosis [4]. Several biological roles of SAA are shown by different studies including immunological, inflammatory, and homeostatic functions. Serum amyloid A have also antimicrobial properties against a wide spectrum of organisms as bacteria, viruses, and fungi [5]. Moreover, it has been shown that SAA protein is involved in the pathogenesis of several inflammatory diseases including rheumatoid arthritis [6] psoriases, [7] coronary artery disease [8], and Urticaria [9]Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. It was originally described as B-stimulating factor 2, which induces B lymphocytes to produce immunoglobulin. It can be rapidly synthesized in the case of infection and tissue damage. Relevant data showed that IL-6 plays a key role in the pathogenesis of inflammatory diseases [10].This study was carried out to detect the expression of SAA and IL-6 in the peripheral blood serum of LP patients through experiments to provide accurate basis for future clinical diagnosis and treatment of LP.