Serum amylase activity disorders in the course of experimental diabetes in rabbits

Burski, K; Ueland, Thor; Maciejewski, Ryszard

doi:10.17221/5695-vetmed

Cited by 14 publications

(14 citation statements)

References 17 publications

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“…In addition, several studies showed that, in models of diabetes with failure for production or resistance of insulin, the activity of amylase in acinar cells was decreased, but lipase activity in pancreatic acinar cell was increased. The reductions of amylase expression along with increment of lipase expression were results that were also confirmed [48][49][50][51][52][53]. In several studies it has been reported that insulin deficiency resulted in pancreatic exocrine dysfunction [53][54][55][56].…”

Section: Discussionsupporting

confidence: 71%

The Protective Effect of Marigold Hydroalcoholic Extract in STZ-Induced Diabetic Rats: Evaluation of Cardiac and Pancreatic Biomarkers in the Serum

2016

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Diabetes mellitus is the most common endocrine disorder worldwide and it is usually along with complications such as retinopathy, neuropathy, nephropathy, and cardiovascular disease. The prevalence of diabetes is increasing and its treatment has created concerns in society. The use of herbal medicine can be helpful in the management of diabetes mellitus. The aim of this study was to investigate the protective effect of marigold hydroalcoholic extract under diabetes condition. A total of 36 male Wistar rats were randomly divided into four groups: normal control group, diabetic control group, and groups treated with 250 or 500 mg/kg hydroalcoholic extract of marigold flower during four weeks. At the end of the study, the rats were anesthetized with ketamine/xylazine, and sampling was performed through cardiac puncture. The results showed that treatment with marigold improved body weight. In addition, we determined that marigold normalized the level of CK-MB, total CK, amylase, and lipase in a dose-dependent manner. Probably these effects resulted from antioxidant property of marigold; thus we suggest that marigold flower can be useful for reduction of diabetes complication.

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Section: Discussionsupporting

confidence: 71%

The Protective Effect of Marigold Hydroalcoholic Extract in STZ-Induced Diabetic Rats: Evaluation of Cardiac and Pancreatic Biomarkers in the Serum

2016

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“…Earlier studies have reported a decrease (at early phase) and increase (late phase) in rabbits sera treated with alloxan and attributed to impaired pancreatic exocrine secretion due to decreased stimulatory action (Hardt et al, 2000;Shimizu et al, 2000) and increased release of enzyme from cellular compartment caused by increased destruction of pancreatic tissue (Burski et al, 2004). In the present experiments, there was a dose-related reduction in serum amylase and lipase in diabetic rats with HEF.…”

Section: Discussionsupporting

confidence: 62%

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

Joshi¹,

Patil²,

Naik³

2014

Pharmaceutical Biology

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Context and objective: The herb fenugreek, Trigonella foenum-graecum Linn (Fabaceae), seeds have been traditionally used in the treatment of diabetes but its effect on oxidative stress and pro-inflammatory cytokines in the improvement of exocrine function of diabetes has not been studied. The effect of hydroalcoholic extract of Trigonella foenum-graecum seeds (HEF) on alloxan-induced type-II diabetic rat model was investigated. Materials and methods: Effect of HEF (500, 1000, and 2000 mg/kg), glimepiride (4 mg/kg), and combination of HEF (500 mg/kg) + glimepiride (2 mg/kg), on alloxan-induced diabetic rats was evaluated by assaying (blood glucose, serum protein, glycosylated hemoglobin, muscle and liver glycogen, glucose uptake by diaphragm, liver glucose transport, serum pancreatic enzymes (a-amylase, lipase), pro-inflammatory cytokines (TNF-a, IL-6), antioxidant enzymes [glutathione (GSH), superoxide dismutase (SOD)], lipid peroxides (liver and pancreas), and histoarchitecture (liver, pancreas). Results: Treatment with HEF (at different doses), glimepiride, and HEF + glimepiride increased body weight and glucose uptake, reduced plasma glucose, glycosylated hemoglobin, liver glucose transport, pro-inflammatory cytokines, pancreatic enzymes and restored depleted glycogen (muscle, liver) and total protein significantly (p50.01) and dose dependently, including prevention of lipid peroxidation and restoration of GSH and SOD (liver and pancreas). Treatment with HEF + glimepiride potentiated hypoglycemic activity of glimepiride. Histoarchitecture of liver and pancreas showed marked improvement. Conclusion: Present experimental findings suggest that HEF possesses promising hypoglycemic activity, presumably by amelioration of oxidative stress and pro-inflammatory cytokines. HEF may be useful as an adjuvant with clinically effective antidiabetic drugs in the management of type-II diabetes.

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“…The present finding came accordance with Burski et al [45] who stated that α-amylase activity in the rabbit serum, within the first three weeks of diabetes, was dropped to the levels below the half of the values noted in healthy controls. Hexokinase plays a central role in the maintenance of glucose homeostasis.…”

Section: Discussionsupporting

confidence: 93%

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

2016

IJSR

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The present study was conducted to investigate the beneficial effects of taurine (TAU) on glucose and lipid metabolism and its positive roles in the correction of oxidative stress diabetes-related complications in STZ diabetic rats. Diabetic rats showed significant (P<0.05) increase in the levels of glucose, HbA1c, AST, ALT, LDH, liver and kidney weights, urea, uric acid, creatinine and significant decrease in the levels of body and pancreas weights, insulin, pancreatic amylase, hexokinase, liver and muscle glycogen, total protein, albumin, antioxidant enzymes and HDL-C. Also, higher levels of cholesterol, TG, total lipids, LDL-C and MDA were noticed in diabetic rats. The taurine administration (50 mg/kg) showed antihyperglycemic effect as indicated by reduced glucose levels, HbA1c and improved insulin level and carbohydrate hydrolyzing enzymes. In addition, taurine supplementation normalized liver function and inhibited lipid prfile alterations while, kidney weight, urea, creatinine, uric acid, total protein and albumin levels were partially improved. The obtained results revealed that taurine exhibited an inhibitory effect on oxidative stress indices (MDA) and partially improved antioxidantlevels. Taurine could have potential as a pharmaceutical drug for diabetes mellitus (DM). Additional study is needed to investigate whether taurine has the same beneficial effects in human diabetic patients.

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Serum amylase activity disorders in the course of experimental diabetes in rabbits

Cited by 14 publications

References 17 publications

The Protective Effect of Marigold Hydroalcoholic Extract in STZ-Induced Diabetic Rats: Evaluation of Cardiac and Pancreatic Biomarkers in the Serum

The Protective Effect of Marigold Hydroalcoholic Extract in STZ-Induced Diabetic Rats: Evaluation of Cardiac and Pancreatic Biomarkers in the Serum

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

Taurine Modulates Hyperglycemia-Mediated Oxidative Stress and Protects Hepatocytes in Experimental Diabetes

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