Serum Amylase Activity and Renal Amylase Activity Clearance in Patients with Severely Impaired Renal Function and in Patients Treated with Renal Allotransplantation

Eb, Pedersen; Brock, Ashton T.; Kornerup, H. J.

doi:10.1080/00365517609055239

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…A high amylase/ creatinine clearance ratio has also been reported in severe renal failure (GFR less than 25 ml/min) by Pedersen et al (1976). The severity of renal insufficiency may explain why the results differ from those previously reported (Blainey and Northam, 1967;Levitt et al, 1969).…”

Section: Discussionmentioning

confidence: 73%

Renal clearance of pancreatic and salivary amylase relative to creatinine in patients with chronic renal insufficiency.

Keogh¹,

McGeeney²,

Drury³

et al. 1978

Gut

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SUMMARY Pancreatic and salivary amylase/creatinine clearance ratios in patients with various degrees of renal impairment were compared with those obtained for control subjects. In chronic renal insufficiency (mean GFR 30 ml/min ± 15 SD; n = 13) the clearance ratios for pancreatic (mean 3X5 + 1X85 SD) and salivary (mean 2.3 + 1-3 SD) amylase were significantly higher (p < 0 05) than those in controls. Corresponding control values (n = 26) were 2-64 + 0-86 (pancreatic) and 1 64 + 0 95 (salivary). Three patients showed values above the normal limit. In the diabetic group (mean GFR 41 ml/min + 22 SD; n = 10) salivary amylase/creatinine clearance ratios (mean 2-36 + 1-55 SD) were significantly higher than in controls (p < 0 05). Three patients showed raised values. Pancreatic amylase clearance was raised in only one of these patients. Three patients with terminal disease (mean GFR 1Oml/min) showed markedly raised (two-to threefold) clearance ratios for both salivary and pancreatic amylase. Of a total of 26 patients, eight had increased total amylase/creatinine clearance ratios. Pancreatic amylase/creatinine clearance was increased in seven patients, while nine patients showed raised salivary amylase/creatinine ratios. Patients with raised clearance ratios did not have clinical evidence of pancreatitis. We suggest that, in the presence of impaired renal function, a high amylase/creatinine clearance ratio need not be indicative of pancreatic disease.

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Section: Discussionmentioning

confidence: 73%

Renal clearance of pancreatic and salivary amylase relative to creatinine in patients with chronic renal insufficiency.

Keogh¹,

McGeeney²,

Drury³

et al. 1978

Gut

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show abstract

“…Also the normal renal handling of amylase has been a matter of disputels). Pedersen et al 14) reported a very close correlation between the clearance of amylase and the clearance of endogeneous creatinine in patients with various degrees of renal failure. As tubular lesions must have been present in some of these cases, the investigation suggested that tubular reabsorption of amylase is negligible in these patients.…”

Section: Discussionmentioning

confidence: 95%

Urinary Concentrations of Total Protein, β2-Microglobulin and Amino Acids in Healthy Newborn Infants

1981

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The urinary concentrations of total protein, low molecular weight proteins, amylase, and total amino acid were determined from 104 healthy newborn infants during the first 15 days of life. The urine samples were collected after spontaneous voiding every two hours. Neonatal proteinuria was found in 70 per cent of 2 day old infants. N o infant older than 8 days showed proteinuria. The ratio of mean value of 02-microglobulin to creatinine was highest on the 5th day of life, followed by a rapid decrease after the 6th day. On the 15th day the 02-microglobulin concentration was still high. The mean ratios of total amino acid to creatinine and amylase to creatinine increased gradually during the first 9 days of life, and then decreased rapidly after the 10th day. The highest urinary concentration of other low molecular weight proteins was found between the 7th and 8th day. On the other hand, the lowest concentration of albumin was found between the 7th and 8th day. These findings suggest that the proximal tubular function is immature in the newborn period. (Acta Paediatr Jpn 23(3):326-332 198 1) KeywordsNewborn infants, urinary protein, low molecular weight protein, total amino acid. analysis was done by them. Karlsson and

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“…Macroamylasemia may be one cause for this (18). We therefore decided to look for the frequency of this condition among our patients with elevated serum amylase activity by using the rapid detection method described by Fridhandler et al (7).…”

mentioning

confidence: 99%

The Frequency of Macroamylasemia and the Diagnostic Value of the Amylase to Creatinine Clearance Ratio in Patients with Elevated Serum Amylase Activity

Dürr

Bindrich

1977

Scandinavian Journal of Gastroenterology

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190 patients with elevated serum amylase levels were tested for macroamylasemia and the amylase to creatinine clearance ratio. Macroamylasemia was found in 3 patients. In these patients macroamylasemia persisted after the total activity of serum amylase had fallen to nearly normal levels. The Cam/Ccr-ratios were determined 14 times in the 3 macroamylasemic patients. Only one of the 14 values was clearly less than 1%. Cam/Ccr-ratios above 4% were found in 83 patients. In 56 of them the diagnosis of acute pancreatitis could not be confirmed. 19 out of 46 patients with the established diagnosis of acute pancreatitis had Cam/Ccr-ratios below 4%. Cam/Ccr-ratios below 1% were also found in patients without macroamylasemia. It is concluded that high and low Cam/Ccr-ratios are not specific for acute pancreatitis and macroamylasemia, respectively, and--moreover--that a normal Cam/Ccr-ratio excludes neither acute pancreatitis nor macroamylesemia.

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Serum Amylase Activity and Renal Amylase Activity Clearance in Patients with Severely Impaired Renal Function and in Patients Treated with Renal Allotransplantation

Cited by 8 publications

References 9 publications

Renal clearance of pancreatic and salivary amylase relative to creatinine in patients with chronic renal insufficiency.

Renal clearance of pancreatic and salivary amylase relative to creatinine in patients with chronic renal insufficiency.

Urinary Concentrations of Total Protein, β2-Microglobulin and Amino Acids in Healthy Newborn Infants

The Frequency of Macroamylasemia and the Diagnostic Value of the Amylase to Creatinine Clearance Ratio in Patients with Elevated Serum Amylase Activity

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