Serum aminoterminal propeptide of type III procollagen in psoriasis and psoriatic arthritis: Relation to liver fibrosis and arthritis

Zachariae, H; Aslam, Hafiz Muhammad; Bjerring, Peter; Søgaard, H; Zachariae, E; Heickendorff, Lene

doi:10.1016/0190-9622(91)70173-y

Cited by 64 publications

(44 citation statements)

References 9 publications

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“…Serum PIIINP levels may be a less reliable marker of liver fibrosis in these patients because elevated levels may be related to active joint disease. 5,12 Transient elastography (TE) using pulse-echo ultrasonography measures the propagation and velocity of the wave in the liver in one dimension, correlating with tissue stiffness and serving as an indirect measure of fibrosis. 13 A meta-analysis 14 of 9 studies involving TE for diagnosing fibrosis showed a sensitivity of 87% and specificity of 91%.…”

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confidence: 99%

The Use of Transient Elastography and FibroTest for Monitoring Hepatotoxicity in Patients Receiving Methotrexate for Psoriasis

et al. 2014

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The Use of Transient Elastography and FibroTest for Monitoring Hepatotoxicity in Patients Receiving Methotrexate for Psoriasis

et al. 2014

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“…Performing a liver biopsy only in patients with an abnormal PIIINP resulted, according to the study of Maurice et al [14], in a 45% reduction of all liver biopsies and the study of Chalmers et al [13 ]in a sevenfold reduction, without important liver damage being missed. Boffa et al [15 ]and Zachariae et al [8, 16, 17 ]also concluded that the chance to develop substantial liver fibrosis and the risks of missing significant liver damage are minimal in case of persisting normal PIIINP values.…”

Section: Discussionmentioning

confidence: 99%

Dermatologists’ Adherence to the Guideline of the Dutch Society of Dermatology and Venereology with Respect to the Treatment with Methotrexate for Severe Chronic Plaque Psoriasis: Results from a Dutch Survey

Berends¹,

Jong²,

Kerkhof³

et al. 2007

Dermatology

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Background: In 2003, the Dutch guideline ‘Photo(chemo) therapy and systemic therapy for severe chronic plaque psoriasis’ was established. Objectives: To document how closely this guideline is followed in clinical practice with respect to the methotrexate (MTX) treatment and to formulate recommendations to adjust the guideline. Methods: A survey was conducted among Dutch dermatologists and residents in dermatology. The questionnaire assessed the knowledge of and the adherence to the guideline with respect to MTX treatment. Results: Fifty percent of the contacted dermatologists/residents responded. Fifty-two percent follow the guideline with respect to MTX. Liver biopsy and the frequency of blood investigations cause a discrepancy between guideline and reality. There is a lack of consensus between guidelines of the different specialisms concerning liver biopsy. Conclusion: The need for liver biopsies in combination with the frequent check-ups and the lack of consensus between rheumatologists, hepatologists and dermatologists seem to restrict the adherence to the guideline.

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“…Both type I and type 111 collagens are synthesized in a precursor form, procollagen, which is characterized by the presence of extension propeptides at the amino-and carboxy-terminal ends [10], During synthesis, the propep tides are released to the circulation, although type III pro collagen may be incorporated to some extent into the con nective tissue retaining its amino-terminal propeptide. In creased serum levels of PIIINP have been reported in a number of conditions characterized by increased tissue fibrosis, such as liver fibrosis [11,12], systemic scleroderma [13] and in various chronic renal diseases [14,15]. At present, there is no information concerning PIIINP and PICP se rum values in renal transplant recipients.…”

Section: Introductionmentioning

confidence: 89%

Serum Propeptides of Type I and III Procollagens in Renal Transplant Recipients

Heickendorff

Frost

Madsen

et al. 1994

Nephron

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Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type III and type I collagens, we analyzed serum levels of the amino-terminal propeptide of type III procollagen (PIIINP) and the carboxy-terminal propeptide of type I procollagen (PICP) in 11 renal transplant recipients receiving cyclosporine (group CY) and a comparable group of 16 renal transplant recipients treated with azathioprine (group AZ). In addition, 27 healthy subjects and 15 patients with chronic renal disease and reduced renal function (group CRD) were examined. The cyclosporine-treated patients had serum PIIINP and PICP similar to the azathioprine-treated patients. Both groups of renal transplant recipients had significantly increased serum PIIINP compared to healthy controls (2p < 0.01) and serum PIIINP levels similar to group CRD in which serum PIIINP was also elevated compared to healthy controls (2p < 0.01). Mean serum PIIINP levels were: group CY 0.81 U/l (n = 11); group AZ 0.98 U/l (n = 16); controls 0.62 U/l (n = 27); and group CRD 1.06 U/l (n = 15). The renal graft recipients – both cyclosporine- and azathioprine-treated patients – had significantly increased PICP serum levels compared to healthy controls, but the patients with chronic renal disease had serum PICP levels which did not differ from that of healthy controls. Mean serum PICP levels were: group CY 174 μg/l; group AZ 151 μg/l; controls 106 μg/l; and group CRD 119 μg/l. A significant positive correlation was seen between serum creatinine and serum PIIINP in the renal graft recipients (r = 0.51, p < 0.01), but not in the patients with chronic renal disease (r =-0.009, p = 0.49). The data point to an increased synthesis of type I and III collagens in renal transplant recipients. The graft is most likely the source of the increased serum PIIINP and PICP levels. It is suggested that the increased serum levels of propeptides derived from collagen metabolism may reflect continuous immunological destruction of renal tissue causing inflammation and fibrosis.

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Serum aminoterminal propeptide of type III procollagen in psoriasis and psoriatic arthritis: Relation to liver fibrosis and arthritis

Cited by 64 publications

References 9 publications

The Use of Transient Elastography and FibroTest for Monitoring Hepatotoxicity in Patients Receiving Methotrexate for Psoriasis

The Use of Transient Elastography and FibroTest for Monitoring Hepatotoxicity in Patients Receiving Methotrexate for Psoriasis

Dermatologists’ Adherence to the Guideline of the Dutch Society of Dermatology and Venereology with Respect to the Treatment with Methotrexate for Severe Chronic Plaque Psoriasis: Results from a Dutch Survey

Serum Propeptides of Type I and III Procollagens in Renal Transplant Recipients

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