Serum Aluminum Levels in Dialysis Dementia

McKinney, T. D.; Basinger, Mark A.; Dawson, E Manasvi; Jones, Mark M.

doi:10.1159/000182802

Cited by 39 publications

(11 citation statements)

References 16 publications

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“…However, excess or defi ciency of trace elements, which was disregarded until several years ago, has recently been noticed as one of the factors that induce complications in dialyzed patients. In 1972, Alfrey et al [1] reported cases of dialysis dementia possibly due to aluminum intoxication [2], A number of observations indicate a high aluminum concentration in plasma, which may accelerate dialysis dementia and re nal osteodystrophy [3][4][5][6]. In the plasma of dialyzed pa tients, zinc concentration is decreased [7,8], and copper concentration increased [7,9].…”

mentioning

confidence: 99%

Trace Element Concentrations in Hair, Fingernails and Plasma of Patients with Chronic Renal Failure on Hemodialysis and Hemofiltration

Marumo¹,

Tsukamoto²,

Iwanami

et al. 1984

Nephron

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Trace element concentrations in hair and fingernails and plasma of nondialyzed, hemodialyzed and hemofiltered patients with chronic renal failure and healthy volunteers were measured by atomic and nameless atomic absorption spectrophotometry and neutron activation analysis. Plasma aluminum concentrations in all three groups of patients were higher than in the controls. Aluminum levels in plasma and red blood cells were higher in hemofiltered patients than in dialyzed patients. The aluminum concentrations in the hair of both nondialyzed and dialyzed patients was higher than in the controls, while that in the hemofiltered patients it was not. These elevated aluminum concentrations appear to be mainly caused by the use of aluminum-contaminated dialysate. Calcium concentrations in the hair of nondialyzed and dialyzed patients were higher than in the controls. Plasma zinc concentrations in all the patients were lower than the controls, and the concentrations in hemofiltered patients were lower than in the dialyzed patients.

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mentioning

confidence: 99%

Trace Element Concentrations in Hair, Fingernails and Plasma of Patients with Chronic Renal Failure on Hemodialysis and Hemofiltration

Marumo¹,

Tsukamoto²,

Iwanami

et al. 1984

Nephron

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“…In the 1980s, a progressively more extensive use of reverse osmosis for dialysis water treatment markedly reduced aluminum levels in the dialysate, with a large reduction in the incidence of dialysis dementia (7). However, it should be kept in mind that in some cases aluminum present in phosphate binders has been found to induce osteomalacia and encephalopathy by accumulation in bone and cerebral tissues (8).…”

Section: Dialysis Dementiamentioning

confidence: 99%

Neurological complications of hemodialysis: state of the art

Rizzo

Frediani²,

Basile³

et al. 2011

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Neurological complications frequently affect chronic kidney disease patients. They are important causes of morbidity and mortality. We present a review of neurological complications affecting hemodialysis patients, focusing on classical and new aspects. Neurological complications can be classified as central or peripheral, but they also include other conditions such as muscle and autonomic disorders. Neurological complications in hemodialysis patients are often underdiagnosed and undertreated. Dialysis treatment can modify the clinical pattern and the course of neurological complications, but it may also directly induce some specific, dialysis-related complications. A strict collaboration between nephrologists, neurologists and other specialists can potentially improve prevention and management of these disorders and improve quality of life for hemodialysis patients.

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“…Serum aluminum concentrations [17] and grey matter aluminum content [18] have been shown to be higher in patients with dialysis encephalopathy than in uremic patients on hemodialysis without neurological symptoms and in nonuremic controls. Ladurneret al [19] concluded from a study of 64 dialysis patients that there is a direct correlation between serum aluminum concentrations and the appearance of dementia as well as electroencephalographic changes.…”

Section: Clinical and Pathophysiologic Featuresmentioning

confidence: 99%