Serum alkaline phosphatase isoenzyme profiles in phenobarbital‐treated epileptic dogs

Gaskill, Cynthia L.; Hoffmann, Walter; Cribb, Alastair E.

doi:10.1111/j.1939-165x.2004.tb00376.x

Cited by 22 publications

(17 citation statements)

References 33 publications

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“…The liver is the primary detoxification and metabolic centre in the body and is prone to damage as a consequence of exposure to toxins (Gaskill et al, 2004). Alkaline phosphatase (ALP) and alanine transaminase (ALT) are important markers of liver damage hence their plasma concentrations were used to assess the hepatotoxicity of the Aloe vera extracts.…”

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confidence: 99%

The Effects of Crude Aqueous and Alcohol Extracts of <em>Aloe Vera</em> on Growth and Abdominal Viscera of Suckling Rats

Beya¹,

Davidson²,

Erlwanger³

2012

Afr. J. Trad. Compl. Alt. Med.

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The gastrointestinal tract of neonates is sensitive to dietary manipulations. When nursing mothers use Aloe vera, their babies are at risk of indirect exposure to Aloe vera via breast feeding or directly as health supplements. The effects of orally administered extracts of Aloe vera in unweaned rats were investigated. Six day old Sprague-Dawley rats were gavaged with aqueous or alcohol extracts of Aloe vera (low dose 50mg. kg -1 or high dose 500mg. kg) daily for eight days. All data were expressed as mean ± SD and analyzed by one way ANOVA. Pups receiving high doses of either extract had a significantly higher body mass gain than the group receiving lower dose (p < 0.05). Tibial length was significantly increased in the high dose aqueous extract group (15-26 %). The differences in growth could not be attributed to circulating insulin-like growth factor-1 as the levels were not significantly different. The caecum was significantly enlarged in the rats that received the high doses of both extracts. Although, there was no significant difference in the non-fasting plasma concentration of glucose and triglycerides, the hepatic lipid and glycogen content were significantly higher (p < 0.001) for the high dose aqueous extract group. The plasma alanine transaminase was not affected by the treatments, however the high doses of the extracts significantly increased plasma alkaline phosphatase activity. Short term administration of Aloe vera extracts resulted in growth promotion, enhanced hepatic storage of metabolic substrates, increased ALP possibly in relation to bone growth and caused hypertrophy of the caecum of neonatal rats. These effects need to be explored further to enhance animal production and health.

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confidence: 99%

The Effects of Crude Aqueous and Alcohol Extracts of <em>Aloe Vera</em> on Growth and Abdominal Viscera of Suckling Rats

Beya¹,

Davidson²,

Erlwanger³

2012

Afr. J. Trad. Compl. Alt. Med.

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“…Results of previous studies indicate that the explanation for such an increase may be the induction of enzymes which results in increased concentrations of izoenzymes L-AP and C-AP within the hepatocytes and their subsequent release in the general circulation (Solter and Hoffmann, 1995;Deng et al, 1996). In support of this theory is a paper (Gaskill et al, 2004) which claims that a significant increase in serum AP during phenobarbitone therapy is the result of increased activities of all three isoenzymes (C-AP, L-AP and B-AP).…”

Section: Resultsmentioning

confidence: 54%

“…A number of studies carried out on dogs (Dayrell-Hart et al, 1991;Chauvet et al, 1995;Foster et al, 2000;Müller et al, 2000;Aitken et al, 2003;Gaskill et al, 2004;Gaskill et al, 2005) report increased activities of alanine transaminase (ALT) and alkaline phosphatase (AP). Increased ALT and AP activities were mainly recorded in patients who did not display clinical signs of hepatopaties.…”

Section: Introductionmentioning

confidence: 96%

Biochemical changes in the blood serum of dogs treated with phenobarbital

Andrić¹,

Popović²,

Stepanović³

et al. 2010

Acta vet. (Beogr.)

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Despite being described as the safest antiepileptic drug of first choice the presented literature data are much varied as far as dog blood serum biochemical parameters are considered. The aim of this study was to investigate the effect of phenobarbitone at different per os doses on the values of selected blood serum biochemical parameters in dogs during both short and long term application. The study was conducted on 30 dogs of different races, both sexes, ranging from 2 to 8 years of age. A total of 15 healthy and 15 dogs suffering from idiophatic epilepsy were observed. During the short term per os application of phenobarbitone (given at 3 week intervals) to the healty population in varied doseses a statistically significant increase in ALT and AP was recorded. Application of 16 mg/kg/day of phenobarbitone to the healthy population during 14 days resulted in a significant increase of ALT ans AP. This increase was dependant on the duration of the treatment. During chronic application of phenobarbitone to dogs suffering from idiopathic epilepsy a significant increase in values of AP and ALT depending on the given dose was recorded. In two of the studied epileptic dogs treated with high therapeutic doses of phenobarbitone clinical signs of hepatotoxicity were recorded. Hepatotoxicity resulted in decreased albumin and total protein concentrations, as well as increased blood serum total bilirubin, AST, ALP and AP. The obtained results indicate that a long term application of phenobarbitone at high therapeutic doses can cause hepatotoxicity. However, there was no relationship between phenobarbitone dosage and duration of therapy and blood glucose, urea, creatinine, total proteins, albumins, total bilirubin, triglycerides and cholesterol

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“…The values of the metabolic substrates in circulation and storage (not shown) in these pups was a reflection homeostasis within the rats' systems. The liver is prone to damage as a consequence of exposure to toxins as the primary metabolic and detoxification centre in the body [25] . Alkaline phosphatase (ALP) and alanine transaminase (ALT) are important markers of liver damage hence their plasma concentrations were used to assess the hepatotoxicity of the honey supplements.…”

Section: Discussionmentioning

confidence: 99%

Growth and Metabolic Response of Suckling Rats Fed with Natural Honey Supplements

Ajibola¹,

Olusakin²,

Oyewale³

et al. 2016

IJFNS

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The growth and metabolic response of unweaned rats fed with honey were investigated. Ten day old Sprague-Dawley rats were gavaged with 50% honey solution (low dose 10 ml/kg or high dose 20 ml/kg) twice daily for ten days. All data were expressed as mean ± SEM and analyzed by one way ANOVA. Pups nourished with honey had 5.41-7.43% body weight gain than untreated rats. Tibial length was significantly increased (p < 0.05) in the honey-fed group than control (6-9%). The differences in growth could be attributed to circulating insulin-like growth factor-1 as the concentrations were also significantly higher in the honey-fed pups. There were no differences in the circulating and stored metabolic substrates (glucose, triglycerides, free fatty acid, cholesterol, lipid and glycogen) between the treatment and control groups. The plasma alanine transaminase was not affected by the treatments, however there was significantly increased plasma alkaline phosphatase activity in the male pups compared with female litter mates. Short term (10-day) oral administration of honey resulted in growth promotion and increased alkaline phosphatase in male rats, possibly in relation to bone growth and caused no liver pathology in neonatal rats. It was concluded that honey supplements administered orally to suckling rats have a positive effect on body weight and linear growth, and these effects are beneficial during weaning and development of fast growing animals.

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Serum alkaline phosphatase isoenzyme profiles in phenobarbital‐treated epileptic dogs

Cited by 22 publications

References 33 publications

The Effects of Crude Aqueous and Alcohol Extracts of <em>Aloe Vera</em> on Growth and Abdominal Viscera of Suckling Rats

The Effects of Crude Aqueous and Alcohol Extracts of <em>Aloe Vera</em> on Growth and Abdominal Viscera of Suckling Rats

Biochemical changes in the blood serum of dogs treated with phenobarbital

Growth and Metabolic Response of Suckling Rats Fed with Natural Honey Supplements

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