Serum alkaline phosphatase activity in hepatitis of infectious mononucleosis

Barondess, Jeremiah A.; Erle, Henry

doi:10.1016/0002-9343(60)90006-1

Cited by 17 publications

(1 citation statement)

References 33 publications

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“…This was followed by the discovery of alterations in serum glutamic oxalacetic transaminase (SCOT) and other hepatic enzymes during the course of disease. (6,131,158) Search for the etiological agent of infectious mononucleosis began in the 1920s, but met with little success until 1942, when Wising (156) reported the successful transmission of classic infectious mononucleosis to a female medical student volunteer who received 250 ml of blood from a patient ill with the acute disease. This successful experiment was not reproducible by Wising in several other attempts, nor by Bang, (4) who carried out a similar set of volunteer experiments.…”

Section: Historical Backgroundmentioning

confidence: 99%

Epstein—Barr Virus

Evans

Niederman

1984

Viral Infections of Humans

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Section: Historical Backgroundmentioning

confidence: 99%

Epstein—Barr Virus

Evans

Niederman

1984

Viral Infections of Humans

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Structural and Functional Abnormalities of Liver in Infectious Mononucleosis

Kilpatrick¹

1966

Arch Intern Med

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Serum sorbitol dehydrogenase activity as an indicator of chemically induced liver damage in rainbow trout

Dixon

Hodson

Kaiser

1987

Enviro Toxic and Chemistry

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The utility of serum sorbitol dehydrogenase activity (SSDH) to diagnose chemically induced liver damage in fish was assessed with rainbow trout. The assay was both precise and repeatable and was unaffected by long‐term sample storage in liquid nitrogen, by fish weight, by sex, or by fasting. Exposure of trout to phenol, p‐chlorophenol, p‐phenoxyphenol, carbon tetrachloride, or copper injected intraperitoneally (i.p.) or added to water, caused an exposure‐dependent increase in SSDH activity. Peak activity occurred 48 h after the start of exposure. Cyanide had no effect on SSDH activity, consistent with previous observations of no hepatotoxicity. The response to toxic chemicals was unaffected by impaired liver function induced by preexposure to excessive levels of dietary carbohydrate. Elevated SSDH activity was strongly correlated to decreased serum protein levels. Hepatic lesions visible at the light‐microscope level were observed with waterborne toxicant exposure; parenchymatous edema was closely associated with increased liver somatic index (LSI). With i.p. dosing, however, biochemical lesions preceded histopathology since no visible lesions or changes in LSI were associated with toxicant exposure. Therefore, SSDH activity provides a good, reliable indicator of sublethal hepatotoxicity in studies of chemical effects on fish.

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Serum alkaline phosphatase activity in hepatitis of infectious mononucleosis

Cited by 17 publications

References 33 publications

Epstein—Barr Virus

Epstein—Barr Virus

Structural and Functional Abnormalities of Liver in Infectious Mononucleosis

Serum sorbitol dehydrogenase activity as an indicator of chemically induced liver damage in rainbow trout

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