Serum albumin predicts survival in patients with hilar cholangiocarcinoma

Waghray, Abhijeet; Sobotka, Anastasia; Marrero, Carlos Romero; Estfan, Bassam; Aucejo, Federico; Menon, KV Narayanan

doi:10.1093/gastro/gow021

Cited by 16 publications

(20 citation statements)

References 33 publications

(18 reference statements)

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“…It is reported that approximately 70% of EHC cases have abnormal liver function [27]. Therefore, higher ALBI reflects liver dysfunction and results in poor prognosis in EHC [19]. Secondly, as shown in our study, higher ALBI grade is associated with higher CA19-9 and CRP, both of which are crucial prognostic factors of EHC [18, 28].…”

Section: Discussionsupporting

confidence: 63%

“…Previous studies on potential prognostic factors of EHC are limited and unsatisfactory. Amongst preoperative ALB, TBIL, CP grade, tumor characteristics, and tumor markers such as CA19-9 and CEA have been established as important prognostic factors [18, 19]. However, the majority of the studies have assessed the prognostic factors only in EHC patients with surgical resection, while most EHC patients present with advanced stage at diagnosis and no curative treatments can be applied [4].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study suggested that low ALB was associated with poor OS in patients with recurrent malignant obstructive jaundice [11]. Recently, low serum level of ALB has also been identified as an independent predictor of survival in EHC [19]. The potential mechanism may be multifactorial.…”

Section: Discussionmentioning

confidence: 99%

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Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma

Wang

Pang

Jin

et al. 2018

Gastroenterology Research and Practice

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Aim Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms. The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC). Methods A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department, were enrolled. Preoperative clinical data were collected to calculate the CP and ALBI grades. The performance of ALBI score in predicting postoperative death was compared with that of CP score by using the receiver operating characteristic (ROC) curve. Kaplan-Meier analysis and Cox regression model were performed for overall survival (OS) analysis. Results The median survival time of our cohort was 12 months, and the 1-year and 2-year survival rates were 56.9% and 12.8%, respectively. The area under the ROC curve of ALBI score for predicting death was significantly greater than the CP score (0.751, 95% CI: 0.641–0.861, P < 0.001 vs. 0.688, 95% CI: 0.567–0.809, P < 0.001). The univariate analysis revealed that the factors related to overall survival of EHC were carbohydrate antigen 19-9, total bilirubin, albumin, ALBI grade, and CP score. In multivariate analysis, ALBI grade (HR = 1.65, 95% CI: 1.04–2.61, P = 0.032), but not CP score, was identified as an independent prognostic model. Conclusion We demonstrated that the ALBI grade could be used as a predictor of survival in unresectable EHC patients.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma

Wang

Pang

Jin

et al. 2018

Gastroenterology Research and Practice

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“…Several studies of liver surgery and other major surgeries have shown that a drop in albumin level correlates with postoperative complications[ 10 ]. Moreover, preoperative serum albumin level has been characterized as an independent factor of recurrence and OS after resection of hepatocellular carcinoma[ 16 ] and of OS in patients with hilar cholangiocarcinoma[ 17 ]. The tumor-like behavior of AE is probably more similar to a cancer such as cholangiocarcinoma than to those cancers frequently related to underlying liver diseases, such as hepatocellular carcinoma which commonly presents with hepatitis and/or cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy

Joliat¹,

Labgaa²,

Demartines³

et al. 2017

WJG

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AIMTo identify a preoperative blood marker predictive of alveolar echinococcosis (AE) recurrence after hepatectomy.METHODSAll consecutive patients who underwent operation for liver AE at the Lausanne University Hospital (CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume (MCV), red blood cell distribution width (RDW), thrombocytes, C-reactive protein (CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic (ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrence-free survival curves were calculated using the Kaplan-Meier method.RESULTSThe cohort included 68 adult patients (37 females) with median age of 61 years [interquartile range (IQR): 46-71]. Eight of the patients (12%) presented a recurrence over a median follow-up time of 76 mo (IQR: 34-128). Median time to recurrence was 10 mo (IQR: 6-11). Median preoperative leukocyte, MCV, RDW, thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/L (IQR: 41-45) for non-recurrent cases and 36 g/L (IQR: 33-42) for recurrent cases (P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840 (95%CI: 0.642-1, P = 0.002). The cut-off albumin level value was 37.5 g/L for sensitivity of 94.5% and specificity of 75%. In multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence (HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively).CONCLUSIONLow preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up.

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“…For example, HP was proposed as pronucleating proteins because they were highly expressed in the fast nucleating bile of patients with cholesterol stones [44]. Waghray et al predicted survival in patients with hilar cholangiocarcinoma by serum albumin [45]. C3 and HP were identified as more abundant in cholangiocarcinoma [46].…”

Section: Cholangiocarcinoma Datasetmentioning

confidence: 99%

Robust Nonnegative Matrix Factorization via Joint Graph Laplacian and Discriminative Information for Identifying Differentially Expressed Genes

et al. 2017

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Differential expression plays an important role in cancer diagnosis and classification. In recent years, many methods have been used to identify differentially expressed genes. However, the recognition rate and reliability of gene selection still need to be improved. In this paper, a novel constrained method named robust nonnegative matrix factorization via joint graph Laplacian and discriminative information (GLD-RNMF) is proposed for identifying differentially expressed genes, in which manifold learning and the discriminative label information are incorporated into the traditional nonnegative matrix factorization model to train the objective matrix. Specifically,L2,1-norm minimization is enforced on both the error function and the regularization term which is robust to outliers and noise in gene data. Furthermore, the multiplicative update rules and the details of convergence proof are shown for the new model. The experimental results on two publicly available cancer datasets demonstrate that GLD-RNMF is an effective method for identifying differentially expressed genes.

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Serum albumin predicts survival in patients with hilar cholangiocarcinoma

Cited by 16 publications

References 33 publications

Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma

Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma

Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy

Robust Nonnegative Matrix Factorization via Joint Graph Laplacian and Discriminative Information for Identifying Differentially Expressed Genes

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