Serum albumin level difference in burn injury after tangential excision: A prospective cohort study

Soedjana, Hardisiswo; Bowo, Setiagung Ambari; Putri, Nandita Melati; Davita, Theresia Risa

doi:10.1016/j.amsu.2020.02.007

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…One factor that can cause changes in the concentration levels of albumin in the body is malnutrition. The level measurement of albumin serum is often used to indicate the nutritional status and health level so that can be used to detect any malnutrition in the body (Soedjana, Bowo, Putri, & Davita, 2020). Thus result was in line with research by Oliveira, Sousa, Araujo, Aarão, & Quaresma (2017) that in some patients with type Mb leprosy was more experienced in patients who have abnormal serum albumin levels.…”

Section: Discussionsupporting

confidence: 67%

Nutrition as a Risk Factor of Child Leprosy in Gresik District 2019

Arifin

Prakoeswa

Prakoswa

et al. 2022

JBE

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Background: Indonesia's annual increase in leprosy is a serious health problem. In east Java, child leprosy cases spread in several counties/cities, the number of new cases of child leprosy cases has been raised in Gresik District from 2015 until 2019. Purpose: This study analyzed characteristics, BCG vaccine status, nutritional status and home environment, the correlated risk factors to child leprosy in Gresik District. Methods: This study used a design population-based matched case-control design and analysis data using computer computing. The variables for this research were characteristics (age, sex, and education) and BCG vaccine status (BCG scar and without BCG scar), nutritional status classified as Body Mass Index (BMI)(normal and thin) and protein (albumin and Hb serum), and home environment (wall, ceiling, floor, humidity, ventilation, and density of occupancy). It was conducted in October 2019-February 2020 using a questionnaire, observation and measurements. The total sample was 36 respondents, of which the number of the case was 18, and the control was 18. Data were analyzed using the Logistic Regression method entered with a 95% CI and an OR. Results: Home environment had not correlated to leprosy cases of children. The completeness of BCG vaccine status correlated to children's leprosy cases (p=0.02). BMI had correlated to leprosy cases of children (p=0.01). The most influential variable was the completeness protein of albumin serum (Odds Ratio (OR) =9.10; 95%CI=1.11-41.44; p=0.01). Conclusion: The most dominant risk factor correlated with the incidence of leprosy is the serum albumin level.

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Section: Discussionsupporting

confidence: 67%

Nutrition as a Risk Factor of Child Leprosy in Gresik District 2019

Arifin

Prakoeswa

Prakoswa

et al. 2022

JBE

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“…Soedjana et al showed serum albumin reduction is highly associated with the increased mortality risk in major burn injuries as the inflammatory mediators induce vascular permeability that causes protein loss into the interstitial space, which results in intravascular fluid, electrolytes and protein depletion. 7 The resulting inflammation in burn patients itself decreases albumin synthesis. This depletion in serum albumin is used for predicting complications in flame burn injury.…”

Section: Change In Albuminmentioning

confidence: 99%

A clinical study on dyselectrolytemia and changes in renal function in patients with 25% to 60% flame burn injury

Mohanty¹,

Dhar²,

Patar³

2021

Int Surg J

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Background: Severe fluid loss is the greatest problem faced following major thermal burn injuries accompanied by changes in the level of electrolytes. Standard fluid resuscitation derived from Parkland’s formula and body’s response to it is measured in terms of correction of dyselectrolytemia and urine output.Methods: A prospective cross sectional study involving 80 patients were included in the study with male patients being 28 and females being 52. Flame burns involving ≥25% - ≤60% of BSA presenting within 24 hours of flame burn injury were taken into account. Serial follow up of serum electrolytes was done on the day of presentation, day 2, day 3 and day 7 its effect on standard fluid resuscitation was studied.Results: Renal function is indirectly related to the percentage of flame burn, hence decreasing urine output and linear increase in serum creatinine is suggestive of increased surface area of burn. The mean serum sodium on the day of admission was roughly normal whereas as the days progressed there was significant hyponatremia with normalisation of day 7, whereas serum potassium was initially normal followed by hyperkalemia.Conclusions: An initial assessment involved calculation of percentage of total body surface area burn injury followed by of estimation of fluid requirement according to standard Parkland formula. Monitoring of electrolyte imbalance was noted for 2nd, 3rd and 7th day of hospitalisation. Derangements in these parameters were observed during course of admission followed by normalisation on the 7th day.

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“…Exudate is generally produced during the inflammatory and proliferative stages of the healing process. In acute wounds, exudate production reduces over time; on the other hand, in chronic and burn wounds and wound dehiscence, large amounts of exudate can be produced, which can lead to a significant amount of albumin loss [9]. Bacterial contamination has a special importance to the chronic inflammation of wounds that do not heal [6,10].…”

Section: Introductionmentioning

confidence: 99%

Pectin–Zeolite-Based Wound Dressings with Controlled Albumin Release

et al. 2022

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Hypoalbuminemia can lead to poor and delayed wound healing, while it is also associated with acute myocardial infarction, heart failure, malignancies, and COVID-19. In elective surgery, patients with low albumin have high risks of postoperative wound complications. Here, we propose a novel cost-effective wound dressing material based on low-methoxy pectin and NaA-zeolite particles with controlled albumin release properties. We focused on both albumin adsorption and release phenomena for wounds with excess exudate. Firstly, we investigated albumin dynamics and calculated electrostatic surfaces at experimental pH values in water by using molecular dynamics methods. Then, we studied in detail pectin–zeolite hydrogels with both adsorption and diffusion into membrane methods using different pH values and albumin concentrations. To understand if uploaded albumin molecules preserved their secondary conformation in different formulations, we monitored the effect of pH and albumin concentration on the conformational changes in albumin after it was released from the hydrogels by using CD-UV spectroscopy analyses. Our results indicate that at pH 6.4, BSA-containing films preserved the protein’s folded structure while the protein was being released to the external buffer solutions. In vitro wound healing assay indicated that albumin-loaded hydrogels showed no toxic effects on the fibroblast cells.

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Serum albumin level difference in burn injury after tangential excision: A prospective cohort study

Cited by 3 publications

References 8 publications

Nutrition as a Risk Factor of Child Leprosy in Gresik District 2019

Nutrition as a Risk Factor of Child Leprosy in Gresik District 2019

A clinical study on dyselectrolytemia and changes in renal function in patients with 25% to 60% flame burn injury

Pectin–Zeolite-Based Wound Dressings with Controlled Albumin Release

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