Serum Albumin Level at Admission: Mortality and Clinical Outcome in Geriatric Patients

D'Erasmo, E; Pisani, Daniela; Ragno, Alessandro; Romagnoli, Stefano; Spagna, G; Acca, M

doi:10.1016/s0002-9629(15)40150-8

Cited by 11 publications

(2 citation statements)

References 17 publications

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“…However, this did not emerge as an independent factor. Therefore, in very elderly people in the community, it might be more useful to complement nutritional assessment with a multidisciplinary approach instead of an analytical approach, which is described as completely different for people living in homecare or patients in hospitals …”

Section: Discussionmentioning

confidence: 99%

Risk of being undernourished in a cohort of community‐dwelling 85‐year‐olds: The Octabaix study

Farré¹,

Formiga

Ferrer

et al. 2013

Geriatrics Gerontology Int

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There is a high risk of being undernourished in 85-year-old subjects. This nutritional status was positively associated with being female, disability, increased social risk and a high number of prescription drugs, whereas there was a protective relationship with cardiovascular prescription. In evaluations of nutritional status in the community, a multidisciplinary assessment is more valid than analytical findings.

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Section: Discussionmentioning

confidence: 99%

Risk of being undernourished in a cohort of community‐dwelling 85‐year‐olds: The Octabaix study

Farré¹,

Formiga

Ferrer

et al. 2013

Geriatrics Gerontology Int

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“…Talvez por ser proteína que permite dosagem mais fácil e rápida que as demais, a albumina está freqüentemente associada à gravidade do paciente, constituindo a hipoalbuminemia indicador prognóstico de pacientes cirúrgicos graves, pacientes de UTI, pacientes com doenças inflamatórias, ou trauma craniencefálico (1,17). Nos pacientes geriátricos, a hipoalbuminemia (< 3,3g/dl), na admissão hospitalar, pode ser utilizada como índice preditivo de mortalidade (8), enquanto que, em unidade de terapia intensiva, o uso de ventilação mecânica foi mais freqüente em pacientes hipoalbuminêmicos, superando em sensibilidade o Apache II (18,24).…”

Section: Jornal Brasileiro De Patologia E Medicina Laboratorialunclassified

Comparação entre a relação PCR/albumina e o índice prognóstico inflamatório nutricional (IPIN)

Corrêa¹,

Angeleli²,

Camargo³

et al. 2002

J. Bras. Patol. Med. Lab.

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Objetivo: Simplificar o cálculo do índice prognóstico inflamatório nutricional (IPIN) empregando número menor de variáveis com conseqüente redução do custo da análise. Materiais e métodos: Foram estudados 54 pacientes e 12 indivíduos-controle com 48 ± 20 (média ± dp) anos de idade. As principais patologias dos pacientes eram: doença arterial periférica (22), pênfigo foliáceo (7), doença inflamatória intestinal (7), trauma (6) e pós-operatório de ortognatia (3). Foram obtidas amostras de sangue periférico, colhidas em jejum para dosagens de proteínas positivas (+) e negativas (-) de fase aguda (PFA) pelo método nefelométrico. Proteína C reativa (PCR), α-1-glicoproteína-ácida (α-1-GA), α-1-antitripsina (α-1-AT) e ceruloplasmina (CER) foram as PFA+ e albumina (Alb), transtiretina (TTR), transferrina (TF) e proteína ligadora do retinol (RBP) foram as representantes das PFA-. Esses valores foram analisados quanto à associação de correlação isolada ou associadamente na fórmula do índice prognóstico inflamatório e nutricional (IPIN = PCR + α-1-GA / Alb + TTR). De acordo com o índice prognóstico inflamatório e nutricional, os pacientes foram classificados em grupo-controle (G1); pacientes sem infecção/inflamação (IPIN < 1, G2) ou com risco de inflamação/infecção (IPIN > 1, G3). Em seguida os pacientes do G3 foram subdivididos em baixo risco (G3A, n = 16); médio risco (G3B, n = 10); alto risco (G3C, n = 6) e com risco de morte (G3D, n = 11). Os resultados foram correlacionados entre si (teste de Spearman) ou submetidos às comparações entre grupos (teste de Kruskall-Wallis). Resultados: Houve relação significativa entre as variáveis PCR × α-1-GA

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Functional measures, inflammatory markers and endothelin-1 as predictors of 360-day survival in centenarians

Szewieczek¹,

Francuz²,

Duława³

et al. 2015

AGE

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Centenarians represent a rapidly growing population. To better characterize this specific age group, we have performed a cross-sectional study to observe associations between functional measures and a range of biochemical markers, including inflammatory markers and their significance as predictors of 360-day survival. Medical history and physical and functional assessment (Mini-Mental State Examination (MMSE), Katz Index (activities of daily living, ADL) and Barthel Index (Barthel Index) of Activities of Daily Living, and Lawton Instrumental Activities of Daily Living Scale (Lawton IADL)) were conducted on 86 101.9 ± 1.2-year-old (mean ± SD) subjects (70 women, 16 men). Blood tests were performed on 84 subjects of whom 43 also had extended biomarker assessment. As a reference group 30 51.8 ± 5.0-year old healthy subjects (20 women, 10 men) were recruited. The centenarians received follow-up phone calls. Fifty-two centenarians (60 %) survived ≥360 days. Longer survival was associated with higher MMSE (hazard ratio, HR = 0.934, 95 % confidence interval (CI) 0.896–0.975, P = .002), ADL (HR = 0.840, 95 % CI 0.716–0.985, P = .032), Barthel Index (HR = 0.988, 95 % CI 0.977–0.999, P = .026), and albumin level (HR .926, 95 % CI 0.870–0.986, P .016) and with lower white blood cell (WBC) (HR = 1.161, 95 % CI 1.059–1.273, P = .001), C-reactive protein (CRP) (HR = 1.032, 95 % CI 1.014–1.050, P < .001), IL-6 (HR = 1.182, 95 % CI 1.047–1.335, P = .007), and endothelin-1 (ET-1) level (HR = 3.711, 95 % CI 1.233–11.169, P = .020). Centenarians had higher 360-day survival probability with MMSE ≥13 (P < .001), ADL ≥1 (P < .001), Barthel Index ≥15 (P < .001), Lawton IADL ≥10 points (P = .009), WBC <8.3 G/L (P = .039), CRP <10 mg/L (P < .001), IL-6 <6 pg/mL (P .002), and ET-1 <1.1 pg/mL (P .007). Our results indicate that functional measures, inflammatory markers, and endothelin-1 are predictors of 360-day survival in centenarians.

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Serum Albumin Level at Admission: Mortality and Clinical Outcome in Geriatric Patients

Cited by 11 publications

References 17 publications

Risk of being undernourished in a cohort of community‐dwelling 85‐year‐olds: The Octabaix study

Risk of being undernourished in a cohort of community‐dwelling 85‐year‐olds: The Octabaix study

Comparação entre a relação PCR/albumina e o índice prognóstico inflamatório nutricional (IPIN)

Functional measures, inflammatory markers and endothelin-1 as predictors of 360-day survival in centenarians

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