“…However, while increasing the lipophilicities of complexes can improve their uptake, it can also have a considerable impact on the nature of their interactions with biomolecules, such as proteins and membranes, which may in fact hinder their uptake, alter their subcellular localisation and/or influence the nature of their interactions with (or even the identity of) their molecular targets within cells. 87,90 Researchers have developed complexes capable of selectively targeting and visualising specific organelles within cells, including the nucleus, mitochondria, lysosomes and endoplasmic reticulum, and have shown Ru(II) polypyridyl complexes to be excellent candidates for use as luminescent probes for ultra-resolution STED microscopy and two-photon imaging. 87,131,143,211,357,358 Furthermore, by conjugating functional molecules, such as targeting peptides, drug molecules and nanomaterials to Ru(II) complexes, the resulting conjugates can be targeted for specific cell types or subcellular organelles and imparted with additional properties such as enhanced solubility, multimodal drug action, altered biodistribution and enhanced circulation times in vivo, etc.…”