Serum albumin and mortality in acutely decompensated heart failure

Uthamalingam, Shanmugam; Kandala, Jagdesh; Daley, Marilyn; Patvardhan, Eshan; Capodilupo, Robert; Moore, Stephanie; Januzzi, James L.

doi:10.1016/j.ahj.2010.09.004

Cited by 161 publications

(147 citation statements)

References 24 publications

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“…18, 19 Previous studies showed that hypoalbuminemia was associated with worse clinical outcomes among patients with heart failure, cancer, stroke, or various other diseases. 19- 22 Plakht et al demonstrated that the serum albumin level on admission of patients with acute MI is an independent prognostic marker for long-term death. 23 Recently, the relationship between CRP and serum albumin (the ratio of CRP to albumin) has been reported as a prognostic marker in patients with various diseases such as severe sepsis, CKD, or cancer.…”

Section: Discussionmentioning

confidence: 99%

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Wada

Dohi

Miyauchi

et al. 2017

Circ J

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Section: Discussionmentioning

confidence: 99%

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Wada

Dohi

Miyauchi

et al. 2017

Circ J

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“…In patients with heart failure, the prevalence of hypoalbuminemia is approximately 20-30%, and it has emerged as an independent risk factor for mortality. 28, 29 The normalization of serum albumin after LVAD implantation has an impact on long-term survival and exercise capacity. 30, 31 These previous results and the present ones imply that it takes longer for patients aged >60 years to recover functional and nutritional status and exercise capacity.…”

Section: Discussionmentioning

confidence: 99%

Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device　― Japanese Multicenter Study ―

Yoshioka

Toda

Ōno

et al. 2018

Circ J

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plantation rule, patients aged >60 years at the time of wait list entry are been being treated nominally with bridge-totransplantation therapy (BTT) but practically with DT. To achieve better clinical results at introduction of DT in Japan, the clinical results and adverse events in these DT patients should be evaluated.In the present study, we compared the clinical results of patients aged >60 years at LVAD implantation with younger patients, and analyzed the adverse events and change of end-organ function on long-term follow-up using a national database. Use of a left ventricular assist device (LVAD) has become standard therapy for end-stage congestive heart failure. 1-6 Age has been shown to have an adverse impact on long-term clinical results for continuousflow LVAD, 2,7,8 but the age at which the risk of an LVAD becomes unacceptable is undefined. Furthermore, studies on the risk factors for mortality after LVAD implantation specifically in elderly patients, are very limited. 8 In Japan, destination therapy (DT) will be approved by the Ministry of Health, Labor and Welfare in the near future but, because of donor shortage and national trans- Yoshiki Sawa, MD, PhD on behalf of the Japanese HeartMateII Investigators Background: Advanced age has an adverse impact on clinical results in left ventricular assist device (LVAD) patients. We compared the clinical results of patients aged >60 years with younger patients using a national Japanese database. Methods and Results:Between April 2013 and December 2016, 300 patients underwent HeartMateII implantation. Of these, 37 patients were ≥60 years at LVAD implantation, and the clinical results of these patients were compared with the other younger 263 patients. At 1 and 3 years the on-device survival was 95%, 91% in younger patients, and 85%, 75% in older patients, respectively (P=0.016), although age was not a risk factor on the multivariate analysis. There was no significant difference between the groups in incidence of various adverse events except stroke. In the propensity-matching cohort, the incidence of stroke was significantly higher in patients aged >60 years (P=0.047). In patients aged >60 years, improvement of renal function was transient and there was no improvement later than 3 months, and recovery of serum albumin level to preoperative value was delayed.Conclusions: There were significant differences in the stroke incidence and recovery of end-organ functions after LVAD implantation. This may have important implications for patient selection in future destination therapy in Japan, where quality of life is an important issue in LVAD support.

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“…5) Uthamalingam, et al also found an increased 1-year mortality in patients presenting with hypoalbuminemia and acutely decompensated CHF. 7) Serum concentrations of BNP and NT-proBNP, and ∆ BNP over time are also predictors of morbidity and mortality in patients with CHF. 11,12) In this study, both BNP and albumin at follow-up were independent predictors, after adjusted known biomarkers of cholesterol, 9,10) hemoglobin, 13,14) and creatinine.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Low serum concentrations of albumin [5][6][7][8] and cholesterol 9,10) are predictors of poor prognosis in patients suffering from CHF. On the other hand, elevated concentrations of B-type natriuretic peptide (BNP) are a strong predictor of CHF, and recent practice guidelines recommend using this biomarker for diagnosis and risk stratification.…”

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confidence: 99%

Correlation Between Serum Concentrations of B-Type Natriuretic Peptide and Albumin in Patients With Chronic Congestive Heart Failure

et al. 2012

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SummaryWhile B-type natriuretic peptide (BNP) and hypoalbuminemia are both predictors of major adverse cardiac events (MACE) in patients with congestive heart failure (CHF), whether these markers are correlated is not known.We retrospectively analyzed data collected in 85 patients presenting with CHF, a left ventricular (LV) ejection fraction (EF) < 50%, and non-ischemic heart disease, followed for a mean of 38 months. Statistical analysis was performed to 1) examine the relationship between a) baseline BNP or albumin concentrations and b) baseline clinical characteristics, 2) identify the correlates of changes in (∆) BNP concentrations, and ∆ albumin concentrations, and 3) ascertain the prognostic value of each variable.Log transformed BNP was correlated with New York Heart Association functional class, total protein and LVEF, while albumin was correlated with a history of diabetes mellitus and total protein. ∆ BNP and ∆ albumin concentrations between baseline and follow-up were correlated (P < 0.0001). The follow-up BNP and albumin concentrations were independent predictors of MACE.BNP and albumin were correlated with different baseline clinical characteristics. The long-term changes in the two markers were inversely correlated and both were independent predictors of CHF. (Int Heart J 2012; 53: 234-237)

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Serum albumin and mortality in acutely decompensated heart failure

Cited by 161 publications

References 24 publications

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device　― Japanese Multicenter Study ―

Correlation Between Serum Concentrations of B-Type Natriuretic Peptide and Albumin in Patients With Chronic Congestive Heart Failure

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Serum albumin and mortality in acutely decompensated heart failure

Cited by 161 publications

References 24 publications

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Independent and Combined Effects of Serum Albumin and C-Reactive Protein on Long-Term Outcomes of Patients Undergoing Percutaneous Coronary Intervention

Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device ― Japanese Multicenter Study ―

Correlation Between Serum Concentrations of B-Type Natriuretic Peptide and Albumin in Patients With Chronic Congestive Heart Failure

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Clinical Results, Adverse Events, and Change in End-Organ Function in Elderly Patients With HeartMateII Left Ventricular Assist Device　― Japanese Multicenter Study ―