Serum Adiponectin Level May be an Independent Predictor of Clear Cell Renal Cell Carcinoma

Abstract

Objectives: To examine whether serum adiponectin or leptin level has the ability to differentiate clear cell renal cell carcinoma (ccRCC) from other subtypes of renal cell carcinoma (RCC) in a Chinese population.Patients and methods: We recruited 198 consecutive patients who were treated with radical or partial nephrectomy in our department from September 2011 to June 2013. Their histological types were all malignant, including clear cell, papillary, chromophobe and unclassified RCC. We also enrolled 86 people with no cancer or cancer-related diseases as normal controls. We measured patients' preoperative blood samples for plasma adiponectin and leptin concentrations using an enzyme-linked immunosorbent assay method. Statistical methods were used to analyze ccRCC and other subtypes as they relate to serum adiponectin/leptin level and other factors such as body mass index or visceral fat area.Results: In our database, normal controls had significantly higher circulating adiponectin (p < 0.001) and leptin levels (p < 0.001) than patients with RCC. Among the 198 RCC patients, 156 patients had ccRCC while 42 patients had other histological types. Serum adiponectin levels were lower in ccRCC patients than in non-clear-cell RCC patients (p = 0.004). However, the plasma leptin level was not differently distributed between ccRCC and non-ccRCC patients (p = 0.940). In multivariate analysis, we found that serum adiponectin level may be an independent predictor for discriminating ccRCC patients from others (p = 0.004). Furthermore, in the ccRCC subgroup, we observed that men with ccRCC had lower leptin (p < 0.001) and adiponectin (p = 0.002) levels, and diabetic patients had lower plasma adiponectin levels (p = 0.001).Conclusions: Lower plasma adiponectin concentration was related to an increased incidence of ccRCC and may act as an independent predictor for ccRCC. Our study may help define the process from obesity to adipose tissue, to cytokines and finally to ccRCC.

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

“…Compared to lean women, overweight/obese women had lower serum adiponectin levels and this difference has statistical signi cance [75]. In addition, adiponectin is negatively associated with a variety of benign and malignant tumors, especially those associated with obesity and insulin resistance, such as leukemia [76], renal carcinoma [77], gastric carcinoma [78] and colon cancer [79].Moreover, , the association of adiponectin with potential tumor-limiting functions has been widely proposed [80].…”

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

“…Compared to lean women, overweight/obese women had lower serum adiponectin levels and this difference has statistical significance [74]. In addition, adiponectin is negatively associated with a variety of benign and malignant tumors, especially those associated with obesity and insulin resistance, such as leukemia [75], renal carcinoma [76], gastric carcinoma [77] and colon cancer [78].…”

Overweight and obesity during adolescence increases the risk of renal cell carcinoma

“…10 Inflammation may contribute to tumour initiation and promotion through multiple mechanisms, 9 such as upregulation of hypoxia-inducible factors (HIF) and downregulation of adiponectin. 11 A better understanding of the role of overweight and obesity earlier in life is needed to target relevant time-windows for prevention efforts. To this end, we aimed to investigate the association between BMI in late adolescence and subsequent risk of RCC in large a national cohort of men in Sweden.…”