Serum adiponectin level in obese and non-obese COPD patients during acute exacerbation and stable conditions

Omar, Maha Z; Issa, Hesham; Ali, Mohammad; Abd-Elhamid, Moustafa Abd-Elaty

doi:10.1016/j.ejcdt.2014.01.004

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Increased serum adiponectin also occurs, demonstrating the role of adipokines in cachexia-related energy imbalances in COPD. 12,13,14,15,16 This study was conducted to identify the relationship between serum adiponectin levels and the degree of frailty measured using the Cardiovascular Health Study (CHS) scoring system 17 , a scoring system that is most widely used and has the broadest validity to determine the degree of frailty in the population of COPD elderly patients in Surabaya. , and was willing to follow the study by signing informed consent and information for consent.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Level of Serum Adiponectin and Frailty in Elderly Patients With Chronic Obstructive Pulmonary Disease

Marfiani

Ichwani²,

Widajanti³

et al. 2020

IJTID

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Elderly are especially prone to the adverse health effects of chronic obstructive pulmonary disease (COPD). COPD is a typical aging disease which is found to be about 12% in the age group more than 64 years old. Frailty is an important geriatics syndrome, while adiponectin is an important adipokine that regulate homeostasis of energy. Adiponectin is affected by age, especially in males. Adiponectin levels increases as subcutaneous fat cells in older men decreases. Increased adiponectin can lead to muscle wasting which will further reduce body weight and body mass index (BMI), which indirectly also increases the degree of frailty. Until now the relationship between adiponectin with frailty degree in advanced COPD is still unknown.The aims of this study was to investigate the relationship between plasma adiponectin level and frailty in COPD elders. This was an observational analytic cross-sectional study. All anthropometric parameters, including weight, height, and body mass index (BMI), were measured. Adiponectin was measured by ELISA methods obtained from venous blood samples. Aged more than or equal to 60 years old, the patients underwent spirometry to determine the degree of airflow limitation and the degree of frailty defined by the Fried criteria. Statistic analysis used Rank Spearman. Thirty-eight male COPD patients became the subject of the study. The average age was 70-74 years, with a total of 13 robust, 12 prefrails and 13 frail patients. Level of adiponectin (mean and SD) in robust, prefrail, and frail were 6.84+ 2.66 , 6.58 + 4.27, and 11.62 + 4.90 respectively, p=0.015. Further analysis showed that level of adiponectin rose progresively with an increasing number of components of frailty. The degree of obstruction mostly with mild (42.1%), and no subjects with very severe. There were an increase in serum adiponectin levels in all subjects. In conclusion, level of adiponectin serum correlates positively with the degree of frailty.

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Section: Introductionmentioning

confidence: 99%

Relationship Between Level of Serum Adiponectin and Frailty in Elderly Patients With Chronic Obstructive Pulmonary Disease

Marfiani

Ichwani²,

Widajanti³

et al. 2020

IJTID

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A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation

2016

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The aims of this systematic review were to determine which blood-based molecules have been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease (COPD) exacerbations (AECOPD) and to ascertain the quality of these biomarker publications. Patients of interest were those that have been diagnosed with COPD. MEDLINE, EMBASE, and CINAHL databases were searched systematically through February 2015 for publications relating to AECOPD diagnostic biomarkers. We used a modified guideline for the REporting of tumor MARKer Studies (mREMARK) to assess study quality. Additional components of quality included the reporting of findings in a replication cohort and the use of receiver-operating characteristics area-under-the curve statistics in evaluating performance. 59 studies were included, in which the most studied biomarkers were C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). CRP showed consistent elevations in AECOPD compared to control subjects, while IL-6 and TNF-α had variable statistical significance and results. mREMARK scores ranged from 6 to 18 (median score of 13). 12 articles reported ROC analyses and only one study employed a replication cohort to confirm biomarker performance. Studies of AECOPD diagnostic biomarkers remain inconsistent in their reporting, with few studies employing ROC analyses and even fewer demonstrating replication in independent cohorts.

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Serum adiponectin level in obese and non-obese COPD patients during acute exacerbation and stable conditions

Cited by 2 publications

References 26 publications

Relationship Between Level of Serum Adiponectin and Frailty in Elderly Patients With Chronic Obstructive Pulmonary Disease

Relationship Between Level of Serum Adiponectin and Frailty in Elderly Patients With Chronic Obstructive Pulmonary Disease

A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation

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