Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans

Lubkowska, Anna; Radecka, Aleksandra; Bryczkowska, Iwona; Rotter, Iwona; Dudzińska, Wioleta

doi:10.3390/ijerph120911528

Cited by 49 publications

(42 citation statements)

References 67 publications

(96 reference statements)

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“…Physical activity increases plasma adiponectin concentrations in humans, and there is a negative association between adiponectin and BMI as well as body fat . Our results demonstrate a correlation between changes in adiponectin and BFP (Figure A), suggesting that participants with greater increases in adiponectin had larger decreases in BFP.…”

Section: Discussionmentioning

confidence: 52%

Does green tea extract enhance the anti‐inflammatory effects of exercise on fat loss?

Bagheri

Rashidlamir

Ashtary‐Larky

et al. 2020

Brit J Clinical Pharma

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Aims Green tea extract (GTE) can exert antiobesity and anti‐inflammatory effects. Our study determined whether the benefits of GTE are summative with exercise‐induced changes in anthropometric indices, and the levels of inflammatory cytokines, adiponectin and irisin in inactive overweight women. Methods Thirty overweight female participants were randomized to 3 groups: endurance training + placebo (ET + P); endurance training + GTE (ET + GTE); and Control (no exercise) + placebo (Control, n = 10). The exercise intervention consisted of an 8‐week endurance‐training programme of 3 sessions per week (aerobics, aerobic circuit training, and fast walking or jogging at a moderate intensity of 40–59% of the heart rate reserve). The dose of GTE used was 500 mg/day in the form of a green tea capsule. Results Body weight, body mass index, waist to hip ratio and body fat percentage were decreased in both ET + P and ET + GTE interventions (P < .001 for both interventions). The reduction of anthropometric values in the ET + GTE group was significantly higher than ET + P interventions (P < .001). Both exercise interventions also significantly (P < .001) increased adiponectin (ET + GTE = 5.28 mg/mL [95% confidence interval {CI}, 4.48 to 6.08] and ET + P = 3.34 mg/mL [95% CI, 2.76 to 3.92]) and decreased high‐sensitivity C‐reactive protein (hs‐CRP; ET + GTE = −0.95 mg/L [95% CI, −1.15 to −0.75] and ET + P = −0.35 mg/L [95% CI, −0.46 to −0.24]). Changes in adiponectin and hs‐CRP were greater (P < .05) in ET + GTE compared to ET + P. There were no significant differences in irisin, interleukin‐6 or tumour necrosis factor‐α between the 3 groups (P > .05). Conclusions GTE improves exercise‐induced body composition by further decreasing exercise‐induced changes in weight, body mass index, waist to hip ratio and body fat percentage. The combination of GTE and exercise also produced greater changes in anti‐inflammatory (increases in adiponectin) and metabolic (decreases in hs‐CRP) markers than exercise alone.

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Section: Discussionmentioning

confidence: 52%

Does green tea extract enhance the anti‐inflammatory effects of exercise on fat loss?

Bagheri

Rashidlamir

Ashtary‐Larky

et al. 2020

Brit J Clinical Pharma

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“…In addition, L/A ratio was higher and correlated with weight and FM in patients. In the literature, adiponectin is negatively correlated with insulin resistance and obesity' parameters like BMI (Maeda et al, 2002;Spranger et al, 2003;Weiss et al, 2004), body weight as well as with lean body mass and the lipid indicators LDL-chol and triglycerides (Lubkowska et al, 2015). In ASD patients, significant lower levels of adiponectin were observed when compared to healthy controls, suggesting a role of adiponectin in this pathology (Fujita-Shimizu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Whereas leptin is recognized as a proinflammatory cytokine, adiponectin downregulates the expression and release of many proinflammatory immune mediators (López-Jaramillo et al, 2014). Considering that adiponectin was negatively correlated with body weight (Lubkowska et al, 2015) and leptin was associated with FM (Dalskov et al, 2015), one can suppose that our data regarding the positive correlations of L/A ratio with weight and FM in patients could be related much more to higher leptin levels than to the L/A ratio, since adiponectin levels were similar between groups. In addition, there was no inverse correlation between leptin and adiponectin in our study.…”

Section: Discussionmentioning

confidence: 99%

Leptin and adiponectin correlations with body composition and lipid profile in children with Autism Spectrum Disorder

Nava-Castro

et al. 2019

Preprint

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Leptin and adiponectin have effects on the regulation of appetite and body composition, but evidence of these relationships in children is still limited. Even though investigations of their role in children with ASD are incipient, the nutritional aspects and eating difficulties that these patients may present are increasingly highlighted, often leading to inadequate nutritional status. This cross-sectional controlled study investigated the levels of adipokines in ASD children in comparison with healthy controls, and their correlations with nutritional aspects and lipid profile. A total of 80 participants (40 ASD and 40 controls) were included and evaluated through anthropometric variables, body composition, and blood samples. ASD participants showed higher levels of leptin, no changes of adiponectin levels in comparison with typically developing children, and a positive correlation between leptin and fat mass. This novel finding supports the role of leptin as a marker of adiposity in ASD children, which is reiterated by the higher leptin/adiponectin ratio and its correlation with fat mass in patients. Inverse correlation of leptin with HDL-cholesterol could only in certain cases be related to the higher adiposity in patients when compared to controls. These results highlight also the importance of assessing the nutritional status of this population.

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“…A study evaluating the relationship between leptin and thyroid hormones in humans with chronic renal failure and transplanted patients showed no correlation of leptin with hemoglobin (MALYSZKO et al, 2006). Conversely, Lubkowska et al (2015) observed negative relationship between leptin doses in the blood and red blood cells, hemoglobin and hematocrit. The negative relation between leptin and corpuscular hemoglobin concentration in this study suggests a possible effect of hypoxia on leptin concentration in female dogs.…”

Section: Discussionmentioning

confidence: 96%

“…Most of the research on leptin and adiponectin effects on the cardiovascular and respiratory system has been conducted on obese and/or diabetic rats and humans (LUBKOWSKA et al, 2015;SENADOR et al, 2009;SIKKA et al, 2010). Moreover, there are few reports of these effects on haematological parameters in domestics animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of leptin and adinopectin on cardiovascular, respiratory and haematological systems of healthy dogs

Queiróz

Macêdo

Chaves

et al. 2017

AVB

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Article historyAdipocytokines are substances produced by adipocytes responsible for the regulation of several physiological processes. Among those substances, leptin and adiponectin have been intensively investigated because of their possible effects on metabolism, reproduction, hematopoiesis and cardiovascular system. The current study aimed to assess the effects of adipocytokines, leptin and adiponectin on cardiac and respiratory functions, as well as on the hematological parameters of healthy female dogs of different breeds. Parameters of rectal temperature, diastolic blood pressure, systolic blood pressure, mean arterial pressure, pulse, heart rate and respiratory rate were evaluated in fifty two healthy female dogs. Blood samples were collected for complete blood count and plasma leptin and adiponectin measurement via ELISA technique. There was no difference in circulating levels of adipocytokines among the different breeds (p ≤ 0,05). Negative correlation between leptin and mean corpuscular hemoglobin concentration was found, while it was positive regarding systolic blood pressure, heart rate and breathing. Adiponectin was positively correlated with red blood cells and platelets and negatively with heart rate, respiratory rate, diastolic blood pressure and pulse. Adipocytokines, leptin and adiponectin, exert regulatory effects on cardiorespiratory function and hematopoiesis in healthy female dogs.

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Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans

Cited by 49 publications

References 67 publications

Does green tea extract enhance the anti‐inflammatory effects of exercise on fat loss?

Does green tea extract enhance the anti‐inflammatory effects of exercise on fat loss?

Leptin and adiponectin correlations with body composition and lipid profile in children with Autism Spectrum Disorder

Effects of leptin and adinopectin on cardiovascular, respiratory and haematological systems of healthy dogs

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