“…The hormone exerts its actions by binding to specific receptors, namely AdipoR1, AdipoR2, and T-cadherin (CDH13), expressed in various tissues, including the liver, muscle, vascular endothelium, central nervous system, and others [ 3 , 19 , 88 ]. Despite its observed neuroprotective effects in cell-based and animal experiments [ 3 , 18 , 21 , 22 , 23 , 24 , 25 ], the role of adiponectin in the pathogenesis of AD in humans remains controversial, with some studies even suggesting its possible deleterious effects in amyloidogenesis [ 22 , 28 , 29 , 30 , 31 ].…”