Serum Adiponectin and hsCRP Levels and Non-Invasive Radiological Methods in the Early Diagnosis of Cardiovascular System Complications in Children and Adolescents with Type 1 Diabetes Mellitus

Gökşen, Damla; Levent, Ertürk; Kar, Sakine; Özen, Samim; Darcan, Şükran

doi:10.4274/jcrpe.1003

Cited by 20 publications

(15 citation statements)

References 41 publications

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“…These changes reflect early changes in myocardial relaxation. DD in diabetic children was reported by other investigators 21)22)23). LV DD in patients with diabets mellitus (DM) may be caused by increased LV diastolic stiffness, deposition of advanced glycation end (AGE) products, and cardiac fibrosis, all as a consequence of DM 3).…”

Section: Discussionmentioning

confidence: 83%

Evaluation of Cardiac Functions in Children and Adolescents with Type 1 Diabetes

Aziz

Abdelghaffar

Hussien

et al. 2017

J Cardiovasc Ultrasound

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BackgroundCardiac dysfunction in patients with type 1 diabetes (T1D) represents one of the serious complications. To evaluate the cardiac function in children with T1D by conventional echocardiography and tissue Doppler imaging (TDI).MethodsThe study included 40 T1D patients (age between 6 and 16 years) with > 5 years duration of diabetes and 42 healthy control children. The patients were subjected to clinical evaluation and laboratory investigations [glycosylated hemoglobin A1c (HbA1c), serum lipids and lipoproteins]. Conventional echocardiography and TDI were performed to patients and controls.ResultsThe patients had lower early diastolic filling velocity (E wave) of the tricuspid valve and mitral valves with a p value of (0.000 and 0.006, respectively). TDI revealed that patients had lower S′velocity of the T1D, shorter isovolumic contraction time, longer isovolumic relaxation time and lower E/E′ of the right ventricle than controls (p value 0.002, 0.001, 0.004, 0.003, and 0.016, respectively). The left ventricle (LV)-T1D of the patients was significantly higher (p value 0.02). Twenty eight patients had poor glycemic control without significant differences between them and those with good glycemic control regarding echocardiographic data. Patients with dyslipidemia (13 patients) had higher late diastolic filling velocity of the mitral valve (A) and the lower LV late tissue velocity (A′) (p wave 0.047 and 0.015). No correlation existed between the duration of illness or the level of HbA1c and the echocardiographic parameters.ConclusionDiabetic children have evidence of echocardiographic diastolic dysfunctions. Periodic cardiac evaluation with both conventional and tissue Doppler echocardiography is recommended for early detection of this dysfunction.

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Section: Discussionmentioning

confidence: 83%

Evaluation of Cardiac Functions in Children and Adolescents with Type 1 Diabetes

Aziz

Abdelghaffar

Hussien

et al. 2017

J Cardiovasc Ultrasound

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“…It is normally present in plasma concentrations of 2–20 μg/mL 43. Most studies comparing adiponectin concentration in obese adolescents with its concentration in healthy controls referred to “low levels” when adiponectin concentration was <5 μg/mL, as compared with its concentration in healthy control subjects at >10 μg/mL 44–46. Therefore, in the present study, we used the same cutoff points.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of cardiometabolic risk factors and metabolic syndrome in obese Kuwaiti adolescents

Boodai¹,

Cherry²,

Sattar³

et al. 2014

DMSO

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BackgroundChildhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this pilot study was to determine the prevalence of cardiometabolic risk factor abnormalities and metabolic syndrome (MetS) in a sample of obese Kuwaiti adolescents, as prevalence data might be helpful in improving engagement with obesity treatment in future.MethodsEighty obese Kuwaiti adolescents (40 males) with a mean (standard deviation) age of 12.3 years (1.1 years) participated in the present study. All participants had a detailed clinical examination and anthropometry, blood pressure taken, and assessment of fasting levels of C-reactive protein, intracellular adhesion molecule, interleukin-6, fasting blood glucose, insulin, liver function tests (alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase), lipid profile (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides), insulin resistance by homeostasis model assessment, and adiponectin. MetS was assessed using two recognized criteria modified for use in younger individuals.ResultsThe cardiometabolic risk factors with highest prevalence of abnormal values included aspartate aminotransferase (88.7% of the sample) and insulin resistance by homeostasis model assessment (67.5%), intracellular adhesion molecule (66.5%), fasting insulin (43.5%), C-reactive protein (42.5%), low-density lipoprotein cholesterol (35.0%), total cholesterol (33.5%), and systolic blood pressure (30.0%). Of all participants, 96.3% (77/80) had at least one impaired cardiometabolic risk factor as well as obesity. Prevalence of MetS was 21.3% according to the International Diabetes Federation definition and 30% using the Third Adult Treatment Panel definition.ConclusionThe present study suggests that obese Kuwaiti adolescents have multiple cardiometabolic risk factor abnormalities. Future studies are needed to test the benefits of intervention in this high-risk group. They also suggest that prevention of obesity in children and adults should be a major public health goal in Kuwait.

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“…High sensitivity C-reactive protein (CRP) is the most studied inflammatory marker in pediatric type 1 diabetes. In healthy adults, CRP levels predict future cardiovascular disease and are linked to endothelial dysfunction [13–15], Most [6, 7, 16–22], but not all studies [23, 24], have demonstrated significant increases in CRP levels in pediatric T1D patients. Soluble intracellular adhesion molecule 1 (sICAM 1) is biochemical marker of endothelial damage and inflammation and is again elevated in pediatric T1D [7, 20, 25–27].…”

Section: Introductionmentioning

confidence: 99%

Glycemic variability predicts inflammation in adolescents with type 1 diabetes

Hoffman

Dye

Huang

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Background Adolescents with type 1 diabetes (T1D) have increased risk of cardiovascular disease as well as elevations in biomarkers of systemic inflammation, plasma protein oxidation and vascular endothelial injury. It is unclear whether hyperglycemia itself, or variations in blood glucose are predictors of these abnormalities. Methods This study was designed to determine the relationship of inflammatory (C-reactive protein, CRP), oxidative (total anti-oxidative capacity, TAOC) and endothelial injury (soluble intracellular adhesion molecule 1, sICAM1) markers to glycemic control measures from 3 days of continuous glucose monitoring (CGM) and to hemoglobin A1c (HbA1c), and HbA1c × duration area under the curve (A1cDur). Results Seventeen adolescents (8 F/9M; age, 13.1 ± 1.6 years (mean±SD); duration, 4.8 ± 3.8 years, BMI, 20.3 ± 3.1 kg/m2; A1c, 8.3 ± 1.2%) were studied. Log CRP but was not related to age, duration, body mass index (BMI), HbA1c, or A1cDUR. TAOC increased as logA1cDUR increased (n = 13, r = 0.61, p = 0.028). CRP and sICAM were not related to CGM average glucose but log CRP increased as 3 day glucose standard deviation increased (r = 0.66, p = 0.006). TAOC increased as glucose standard deviation increased (r = 0.63, p = 0.028). Conclusions Increased glucose variability is associated with increased inflammation in adolescents withT1D. Increased TAOC with increasing variability may be an effort to compensate for the ongoing oxidative stress.

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Serum Adiponectin and hsCRP Levels and Non-Invasive Radiological Methods in the Early Diagnosis of Cardiovascular System Complications in Children and Adolescents with Type 1 Diabetes Mellitus

Cited by 20 publications

References 41 publications

Evaluation of Cardiac Functions in Children and Adolescents with Type 1 Diabetes

Evaluation of Cardiac Functions in Children and Adolescents with Type 1 Diabetes

Prevalence of cardiometabolic risk factors and metabolic syndrome in obese Kuwaiti adolescents

Glycemic variability predicts inflammation in adolescents with type 1 diabetes

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