Serum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness

Yazıcı, Dilek; Yavuz, Dilek; Öğünç, Ayliz Velioğlu; Sirikci, Onder; Toprak, Ahmet; Deyneli, Oğuzhan; Akalın, Sema

doi:10.1089/met.2011.0052

Cited by 22 publications

(10 citation statements)

References 37 publications

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“…Meanwhile, significant increases in BMI, random blood sugar, HbA1c, and resistin level were observed in the diabetic children compared with the control group (p < 0.0001). This agreed with a recent study of Yazıcı et al (28) that reported higher resistin levels in type-1 diabetic patients compared with the controls, as well as many other studies (29,30). Conversely, a previous work of Schäffler et al reported lower resistin concentrations in adult patients with type-1 diabetes compared with healthy control subjects with a similar age range.…”

Section: Discussionsupporting

confidence: 92%

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

Al‐Biltagi

Tolba

Mawlana

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Section: Discussionsupporting

confidence: 92%

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

Al‐Biltagi

Tolba

Mawlana

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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“…While higher leptin levels have been associated with CV events in the general population, the association of leptin with subclinical atherosclerosis is unclear. [35, 36] Our results are in agreement with another CTA study where leptin was not associated with plaque presence or extent. [37]…”

Section: Discussionsupporting

confidence: 91%

Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men

Ketlogetswe

Post

et al. 2014

Aids

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Objective To examine if altered levels of adipokines, adipose-derived peptides associated with myocardial infarction in the general population, may contribute to subclinical coronary atherosclerosis in HIV-infected persons. Design Nested cohort study. Methods We studied HIV-infected(HIV+) and HIV-uninfected(HIV−) men in the Multicenter AIDS Cohort Study with noncontrast CT to measure coronary artery calcium and regional adiposity; 75% additionally underwent coronary CT angiography to measure plaque composition and stenosis. Adiponectin and leptin levels were assessed. Multiple regression models were used to assess associations between adipokine levels and HIV disease parameters, regional adiposity, and plaque adjusted for age, race, HIV serostatus and CVD risk factors (RFs). Results Significant findings were limited to adiponectin. HIV+ men (n=493) had lower adiponectin levels than HIV− men (n=250) after adjusting for CVD RFs (p<0.0001), which became non-significant after adjustment for abdominal visceral and thigh subcutaneous adipose tissue. Among HIV+ men, lower adiponectin levels were associated with higher CD4+ T cell counts (p= 0.004), longer duration of antiretroviral therapy (p= 0.006) and undetectable HIV RNA levels (p = 0.04) after adjusting for age, race and CVD RFs; only CD4+ cell count remained significant after further adjustment for adipose tissue. In both groups, lower adiponectin levels were associated with increased odds of coronary stenosis > 50% (p <0.007). Lower adiponectin levels were associated with increased extent of plaque in HIV+ and of mixed plaque in HIV− men. Conclusions Adiponectin levels were lower in HIV-infected men and related to the severity of subclinical atherosclerosis, independent of traditional CVD risk factors.

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“…In the current study, resistin was significantly higher in diabetic subjects than in control subjects. Other studies have reported comparable results [17, 23]. Shalev et al .…”

Section: Discussionsupporting

confidence: 64%

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Ismail¹,

Hamid²,

Ibrahim³

et al. 2017

aoms

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IntroductionAdiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes.Material and methodsFifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay.ResultsThere were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA1c) (p = 0.006), while other adipokines were not interrelated.ConclusionsThese results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes.

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Serum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness

Abstract: Increased adiponectin correlates negatively and resistin positively with CIMT in type 1 diabetic patients, but adjusting for other known predictors reveals only resistin to be associated with subclinical atherosclerosis in this group of patients.

Cited by 22 publications

References 37 publications

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study

Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

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