Serum Adhesion Molecules in Acute Pancreatitis

Pezzilli, Raffaele; Corsi, Massimiliano M.; Barassi, Alessandra; Morselli-Labate, Antonio Maria; D’Alessandro, Alessandro; Dogliotti, Giada; Fantini, Lorenzo; Malesci, Alberto; Corinaldesi, Roberto; d’Eril, Gianvico Melzi

doi:10.1097/mpa.0b013e31816074df

Cited by 23 publications

(9 citation statements)

References 24 publications

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“…In a small study of Powell et al [132], serum soluble P-selectin concentrations during 3 days from admission did not differ between mild and severe AP, but were significantly higher in non-survivors than survivors. To the contrary, Pezzilli et al [123] reported lower soluble P-selectin in SAP patients’ sera as compared to those with mild AP and healthy controls.…”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 98%

“…It was suggested that the peak soluble E-selectin concentrations are observed late (after 72 h from the onset of AP symptoms) and can therefore not be used as an early marker of AP severity [135,136]. During first 6 h from the onset of pain, Pezzilli et al [123] did not observe higher soluble E-selectin in AP patients compared to healthy controls; however, it was higher in SAP than in mild AP. Ida et al [126] did not show significant difference in soluble E-selectin on admission and on subsequent days in those who died from AP compared to survivors.…”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

“…Pezzilli et al [123] observed higher concentrations of soluble ICAM-1 in patients with SAP versus mild AP. This result is, however, depreciated by the fact that the levels in patients with AP were not significantly different compared to healthy volunteers.…”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

See 2 more Smart Citations

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Dumnicka

Maduzia

Ceranowicz

et al. 2017

IJMS

154

113

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Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in substantial mortality. Early pathologic events in AP, both local and systemic, are associated with vascular derangements, including endothelial activation and injury, dysregulation of vasomotor tone, increased vascular permeability, increased leukocyte migration to tissues, and activation of coagulation. The purpose of the review was to summarize current evidence regarding the interplay between inflammation, coagulation and endothelial dysfunction in the early phase of AP. Practical aspects were emphasized: (1) we summarized available data on diagnostic usefulness of the markers of endothelial dysfunction and activated coagulation in early prediction of severe AP; (2) we reviewed in detail the results of experimental studies and clinical trials targeting coagulation-inflammation interactions in severe AP. Among laboratory tests, d-dimer and angiopoietin-2 measurements seem the most useful in early prediction of severe AP. Although most clinical trials evaluating anticoagulants in treatment of severe AP did not show benefits, they also did not show significantly increased bleeding risk. Promising results of human trials were published for low molecular weight heparin treatment. Several anticoagulants that proved beneficial in animal experiments are thus worth testing in patients.

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Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 98%

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

See 1 more Smart Citation

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Dumnicka

Maduzia

Ceranowicz

et al. 2017

IJMS

154

113

View full text Add to dashboard Cite

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“…Other markers of endothelial activation and dysfunction were shown to be increased in severe AP, including soluble E-selectin, tissue factor or von Willebrand factor and endothelial-specific microRNAs [5,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis

Dumnicka

Sporek

Mazur-Laskowska³

et al. 2016

IJMS

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Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay. Serum concentrations of sFlt-1 were significantly higher in patients with MSAP and SAP as compared to MAP. SAP patients had the highest concentrations. At 24 and 48 h, sFlt-1 positively correlated with inflammatory markers (leukocyte count, C-reactive protein), kidney function (creatinine, urea, cystatin C, serum and urine neutrophil gelatinase-associated lipocalin, urine albumin/creatinine ratio), D-dimer and angiopoietin-2. sFlt-1 positively correlated with the bedside index of severity in AP (BISAP) score and the duration of hospital stay. Serum sFlt-1 above 139 pg/mL predicted more severe AP (MSAP + SAP). In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity.

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“…It is generally believed that inflammatory response plays a central role during this process [3,[8][9][10], of which the activation of ICAM-1, TLR4 and NF-κB proteins are important. Through mutual enhancements, these proteins can lead to deterioration in inflammatory injury [11][12][13][14][15][16]. Additionally, abnormal apoptosis present in multiple organs can also give rise to abnormal changes in the structure and function of these organs [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

Zhang

Liang

et al. 2009

Inflammation

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To observe the protective effects of Salvia miltiorrhizae injection on multiple organs of rats with SAP or OJ. Two hundred eighty-eight rats were used for SAP-associated experiments and OJ-associated experiments. The rats were randomly divided into sham-operated, model control and treated group. According to the different time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The mortality rates, pathological changes and ICAM-1 (only in lung), TLR4 (only in liver), Bax and NF-kappaB proteins expression in multiple organs (liver, kidney, lung, intestinal mucosa, spleen, thymus and lymph nodes) were observed, respectively. The mortality rates of treated groups decreased in both SAP and OJ experiments. Compared to model control group, the pathological changes can be seen in treated groups including; (1) the pathological changes of multiple organs in SAP and OJ experiments were improved, the pathological severity scores of kidney (at 6 h), intestinal mucosa (at 12 h), spleen (at 6 and 12 h), thymus (at 3 and 6 h) and lymph nodes (at 3 and 6 h) in SAP experiment and of liver (on 21 and 28 days), lung (21 days), intestinal mucosa (on 21 and 28 days) and spleen (on 21 and 28 days) in OJ experiment significantly declined (P < 0.05 or P < 0.01); (2) the positive rate of Bax protein in pancreas (at 3 h) and liver (on 6 and 12 h) in SAP experiment and in liver (on 28 days), kidney (on 21 days), and thymus (on 28 days) in OJ experiment were significantly lower (P < 0.05 or P < 0.01); (3) the positive rate of NF-kappaB in liver (at 12 h) and kidney (at 6 h) in SAP experiment and in liver (on 21 days), kidney (on 28 days), intestinal mucosa (on 28 days) and thymus (on 14 days) in OJ experiment significantly decreased (P < 0.05). (4) the positive rate of ICAM-1 in lungs (at 12 h) in SAP experiment was significantly less (P < 0.05). Salvia miltiorrhizae injection can protect multiple organs of SAP or OJ rats and inhibit the expression of ICAM-1, TLR4, NF-kappaB and regulate Bax proteins. Salvia miltiorrhizae may relieve the inflammation response and enhance the immunity function of SAP and OJ rats.

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Serum Adhesion Molecules in Acute Pancreatitis

Abstract: This score seems to be useful for the early assessment of the severity of acute pancreatitis.

Cited by 23 publications

References 24 publications

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis

Effects of Salvia Miltiorrhizae on ICAM-1, TLR4, NF-κB and Bax Proteins Expression in Multiple Organs of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

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