Serum Adenosine Deaminase as Inflammatory Marker in Rheumatoid Arthritis

Vinapamula, Kiranmayi S; Pemmaraju, Srinivasarao V L N; Bhattaram, Siddartha Kumar; Bitla, Aparna R.; Manohar, Suchitra M.

doi:10.7860/jcdr/2015/14296.6483

Cited by 25 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extracellular levels of adenosine are also influenced by extracellular ecto-adenosine deaminase (ecto-ADA, that metabolize adenosine to inosine), which is physiologically relevant because its activity regulates AR function (Karmouty-Quintana et al, 2013; Pacheco et al, 2005). Indeed, increased ecto-ADA activity is considered a marker of inflammation (Vinapamula et al, 2015) and atherosclerosis (Kutryb-Zajac et al, 2016).…”

Section: Adenosine Synthesismentioning

confidence: 99%

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Leiva

Guzmán-Gutiérrez

Contreras-Duarte

et al. 2017

Molecular Aspects of Medicine

View full text Add to dashboard Cite

Adenosine as well as agonists and antagonists for the four adenosine receptor subtypes (A1R, A2AR, A2BR and A3R) play a role in several key physiological and pathophysiological processes, including the regulation of vascular tone, thrombosis, immune response, inflammation, and angiogenesis. This review focuses on the adenosine-mediated regulation of lipid availability in the cell and in the systemic circulation as well in humans and animal models. Therefore, adenosine, mainly by acting on A1R, inhibits lipolysis activity, leading to reduction of the circulating fatty acid levels. This nucleoside can also participate in the early development of atherosclerosis by inhibiting the formation of foam cells via stimulation of cholesterol efflux through A2AR expressed on macrophages and reduction of the inflammatory process by activating A2AR and A2BR. Adenosine also appears to modulate intracellular cholesterol availability in Niemann-Pick type C1 disease and Alzheimer disease via A2AR and A3, respectively. Remarkably, the role of adenosine receptors in the regulation of plasma total cholesterol and triglyceride levels has been studied in animal models. Thus, an anti-atherogenic role for A2BR as well as a pro-atherogenic role of A2AR and A1 have been proposed; A3R has not been shown to participate in the control of lipid levels or the development of atherosclerosis. Surprisingly, and despite the role of A2A in the inhibition of foam cell formation among isolated cells, this receptor appears to be pro-atherogenic in mice. Remarkably, the role of adenosine receptors in human dyslipidaemia and atherosclerosis must to be elucidated. Additionally, it has been reported that increased lipid levels impair the effects of adenosine/adenosine receptors in controlling vascular tone, and we speculate on the possibility that this impairment could be due to alterations in the composition of the membrane microdomains where the adenosine receptors are located. Finally, a possible role for adenosine/adenosine receptors in the phenomena of dyslipidaemia in pregnancy has been proposed.

show abstract

Section: Adenosine Synthesismentioning

confidence: 99%

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Leiva

Guzmán-Gutiérrez

Contreras-Duarte

et al. 2017

Molecular Aspects of Medicine

View full text Add to dashboard Cite

show abstract

“…These data suggested that low expression of CD39 on Treg cells could be a biomarker for identifying MTX-resistance rheumatoid arthritis patients. Vinapamula et al [27] have found that serum ADA levels were higher in rheumatoid arthritis patients ( N = 46) compared to controls ( N = 46), which suggested that serum ADA could be as inflammatory marker for rheumatoid arthritis patients. However, we recently investigated the serum ADA levels in 60 rheumatoid arthritis patients and 60 healthy controls (age and sex matched, Chinese people), and our results showed that there was no significant difference of serum ADA in RA patients compared to controls (unpublished data).…”

Section: Adenosine Pathway Changes In Human Autoimmune Diseasesmentioning

confidence: 99%

The role of adenosinergic pathway in human autoimmune diseases

2016

View full text Add to dashboard Cite

Autoimmune diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state of appropriate immune response to nonself-antigen and unresponsiveness to self-antigens. In normal situation, immune homeostasis is regulated by immunosuppressive signal and immunostimulating signal together. Accumulating data have demonstrated that the adenosinergic pathway played key roles in immune suppression and shield body from an excessive inflammatory response. The deficiency of adenosinergic pathway results in the imbalance between the pro- and anti-inflammatory activities. Thus, researchers pay much attention to the role of adenosinergic pathway in autoimmune diseases development. To date, accumulating data have suggested an important role of adenosinergic pathway-related molecules (i.e., CD39, CD73, ADA, adenosine receptors, etc.) in many types of human autoimmune diseases. More importantly, these findings have presented potential value of adenosinergic pathway analysis to be used for autoimmune diseases diagnosis, monitoring and treatment. In this review, we will provide a comprehensive description of the role of adenosinergic pathway in human autoimmune diseases.

show abstract

“…Vinapamula et al found significant positive correlation between serum ADA and CRP in RA patients. They reported cut-off value of 25.3 IU/L for serum ADA level in RA with 82.6% sensitivity and 65.2% specificity (34). It seems that cut off point for serum and synovial level of ADA is an important factor that influences various results in different studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Adenosine Deaminase Level in Serum and Synovial Fluid in Patients with Juvenile Idiopathic Arthritis and Its Relation to Inflammatory Acute Phase Reactants

Rahmani¹,

Raeeskarami²,

Ziaee³

et al. 2017

Iran J Pediatr

View full text Add to dashboard Cite

Background: In JIA, cell-mediated immune response results in secretion of different inflammatory products from activated lymphocytes, macrophages, fibroblasts and leukocytes in synovial joints. Adenosine deaminase (ADA) regulates this immune system activity by metabolizing adenosine through purine metabolic pathway. Objectives: The aim of this study was to compare the level of serum ADA with synovial fluid ADA in JIA patients and to see whether it can be utilized as a marker for the activity of the disease Methods: JIA was diagnosed based on International League of Associations for Rheumatology diagnosis criteria. ADA was measured using special kits. Results: 80% of the patients had oligoarticular and 20% polarticulare JIA. There was a significant relation between erythrocyte sedimentation rate (ESR) and high level of synovial fluid ADA. Synovial ADA level was significantly higher than serum ADA in polyarticular JIA. C-reactive protein (CRP), leukocytes and platelets count were increased in high levels of synovial fluid ADA. No correlation was observed between level of serum and synovial fluid ADA. Conclusions: Synovial fluid ADA seems a more precise index than serum ADA to assess the inflammatory condition. In addition, acute-phase response reactants such as ESR, CRP, and platelets count could be suitable predicting parameters for arthritis.

show abstract

Serum Adenosine Deaminase as Inflammatory Marker in Rheumatoid Arthritis

Cited by 25 publications

References 17 publications

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

The role of adenosinergic pathway in human autoimmune diseases

Comparison of Adenosine Deaminase Level in Serum and Synovial Fluid in Patients with Juvenile Idiopathic Arthritis and Its Relation to Inflammatory Acute Phase Reactants

Contact Info

Product

Resources

About