Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929 participants

Xuan, Chao; Tian, Qing; Zhang, Shaoyan; Li, Hui; Tian, Tingting; Zhao, Peng; Yue, Kang; Ling, Yanyan; He, Guo‐Wei; Liu, Limin

doi:10.1177/2040622319891539

Cited by 13 publications

(8 citation statements)

References 34 publications

(37 reference statements)

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“…We found that various metabolites in the metabolic pathway are closely related to the risk of CAD. 37 Hcy is formed in the one-carbon metabolism pathway during the metabolism of methionine to cysteine, and can also be used to regenerate methionine by vitamin B12. 38 Other studies have shown that serum Hcy levels are significant in CAD patients and that it is an independent risk factor for the disease.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of Serum Amino Acids and Association with Early-Onset Coronary Artery Disease

Xuan

Tian

et al. 2021

CIA

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Background: Amino acids play essential roles in protein construction and metabolism. Our study aims to provide a profile of amino acid changes in the serum of patients with earlyonset coronary artery disease (EOCAD) and identify potential disease biomarkers. Methods: Ultra-performance liquid chromatography-multiple reaction monitoringmultistage/mass spectrometry (UPLC-MRM-MS/MS) was used to determine the amino acid profile of patients with EOCAD in sample pools. In the validation stage, the serum levels of candidate amino acids of interest are determined for each sample. Results: A total of 128 EOCAD patients and 64 healthy controls were included in the study. Eight serum amino acids associated with disease state were identified. Compared with the control group, serum levels of seven amino acids (L-Arginine, L-Methionine, L-Tyrosine, L-Serine, L-Aspartic acid, L-Phenylalanine, and L-Glutamic acid) increased and one (4-Hydroxyproline) decreased in the patient group. Results from the validation stage demonstrate that serum levels of 4-Hydroxyproline were significantly lower in myocardial infarction (MI) patients (9.889 ± 3.635 μg/mL) than those in the controls (16.433 ± 4.562 μmol/L, p < 0.001). Elevated serum 4-Hydroxyproline levels were shown to be an independent protective factor for MI (OR = 0.863, 95% CI: 0.822-0.901). The significant negative correlation was seen between serum 4-Hydroxyproline levels and cardiac troponin I (r = −0.667) in MI patients. Conclusion: We have provided a serum amino acid profile for EOCAD patients and screened eight disease state-related amino acids, and we have also shown that 4-Hydroxyproline is a promising target for further biomarker studies in early-onset MI.

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Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of Serum Amino Acids and Association with Early-Onset Coronary Artery Disease

Xuan

Tian

et al. 2021

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“…Inflammation exerts an important role in the development and progression of various diabetic complications. ADA is highly expressed in lymphoid tissues and is essential for the proliferation and differentiation of T lymphocytes as well as the regulation of the maturation and function of monocytes and macrophages ( 23 ). The expression of ADA is significantly increased in tissues rich in macrophage in a rat model of fecal peritonitis ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients

et al. 2021

Endocrine Connections

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Background: Prolonged heart rate-corrected QT (QTc) interval may reflect poor prognosis of patients with type 2 diabetes (T2D). Serum adenosine deaminase (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammation, which may participate in diabetic complications. We investigated the association of serum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D. Methods: In this cross-sectional study, a total of 492 patients with T2D were recruited. Serum ADA levels were determined by venous blood during fasting. QTc interval was estimated from resting 12-lead electrocardiograms, and prolonged QTc interval was defined as QTc > 440 ms. Results: In this study, the prevalence of prolonged QTc interval was 22.8%. Serum ADA levels were positively associated with QTc interval (r = 0.324, p < 0.0001). The proportion of participants with prolonged QTc interval increased significantly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in the third tertile (T3) of ADA (p for trend <0.001). After adjusting for other possible risk factors by multiple linear regression analysis, serum ADA level was still significantly associated with QTc interval (β = 0.217, t = 3.400, p < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379-10.864, p < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290-13.860, p = 0.017) and ADA (OR 1.212, CI 1.094-1.343, p < 0.001) were independent contributors to prolonged QTc interval. Conclusions: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D.

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“…We recently focused on the relationship between one-carbon metabolism and CVD. We found that various metabolites in the metabolic pathway are closely related to the risk of CAD [28]. Hcy is formed in the onecarbon metabolism pathway during the metabolism of methionine to cysteine, and can also be used to regenerate methionine by vitamin B12 [29].…”

Section: Discussionmentioning

confidence: 99%

Serum Amino Acid Profile in Early-onset Coronary Artery Disease Patients

Xuan

Tian

et al. 2020

Preprint

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Background: Amino acids play essential roles in protein construction and metabolism. Our study aims to provide a profile of amino acid changes in the serum of patients with early-onset coronary artery disease (EOCAD) and identify potential disease biomarkers.Methods: Ultra-performance liquid chromatography-multiple reaction monitoring-multistage/mass spectrometry (UPLC-MRM-MS/MS) was used to determine the amino acid profile of patients with EOCAD in sample pools. In the validation stage, the serum levels of candidate amino acids of interest are determined for each sample.Results: A total of 128 EOCAD patients and 64 healthy controls were included in the study. Eight serum amino acids associated with disease state were identified. Compared with the control group, serum levels of seven amino acids (L-Arginine, L-Methionine, L-Tyrosine, L-Serine, L-Aspartic acid, L-Phenylalanine, and L-Glutamic acid) increased and one (4-Hydroxyproline) decreased in the patient group. Results from the validation stage demonstrate that serum levels of 4-Hydroxyproline were significantly lower in myocardial infarction (MI) patients (9.889 ± 3.635 μg/ml) than those in the controls (16.433 ± 4.562 μmol/L, p < 0.001). Elevated serum 4-Hydroxyproline levels were shown to be an independent protective factor for MI (OR = 0.863, 95% CI: 0.822-0.901). The significant negative correlation was seen between serum 4-Hydroxyproline levels and cardiac troponin I (r = -0.667) in MI patients.Conclusion: We have provided a serum amino acid profile for EOCAD patients and screened eight disease state-related amino acids, and we have also shown that 4-Hydroxyproline is a promising target for further biomarker studies in early-onset MI.

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Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929 participants

Cited by 13 publications

References 34 publications

Quantitative Assessment of Serum Amino Acids and Association with Early-Onset Coronary Artery Disease

Quantitative Assessment of Serum Amino Acids and Association with Early-Onset Coronary Artery Disease

The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients

Serum Amino Acid Profile in Early-onset Coronary Artery Disease Patients

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