Serum "Acid" Phosphatase in Patients With Carcinoma of the Prostate Gland

Levels of Prostate Specific Antigen that Predict Skeletal Spread in Prostate Cancer

“…Tumour markers may be used for screening, monitoring or staging patients with malignant disease. The advent of PSA (Wang et al, 1979) has caused a widespread reappraisal of the role of serum markers in prostate cancer; in this study the ability of serum PSA correctly to stage M1 disease (patients with skeletal metastases) has been examined and compared with the "standard" SAP method introduced 50 years ago (Gutman and Gutman, 1938).…”

“…The finding of raised levels of serum acid phosphatase (Gutman and Gutman, 1938) has for many years assisted in the identification of such patients and despite the recognition that normal values may be found in a minority of patients with bony disease (Heller, 1987), elevated levels of the enzyme may, particularly in the presence of negative 99Tc scintigraphy, provide warning of tumour dissemination and thus prevent inappropriate treatment being offered to patients with occult metastatic disease.…”

Radioimmunoassay for Prostatic Acid Phosphatase in Early Prostatic Carcinoma

“…The reports from Gutman and his colleagues about 45 years ago (Gutman et al, 1936;Gutman and Gutman, 1938;Gutman, 1942) established the role of serum acid phosphatase assays (E.C. 3.1.3.2.)…”

Purification and characterization of a new human prostatic acid phosphatase isoenzyme

“…In addition to seminal plasma, PAP-II is detected only in tissue extracts of carcinoma Since Gutman et al reported the association between acid phosphatase activity and prostate cancer in 1936 (Gutman et al, 1936), this enzyme has been extensively studied for the past 5 decades (Schwartz et al, 1969;Yam, 1974; Chu et al, 1982). The elevation of acid phosphatase activity in sera from patients with prostate cancer is probably caused by the leakage of this enzyme during metastasis (Gutman, 1942). Prostatic acid phosphatase (PAP-I)1 has been purified to homogeneity as demonstrated by polyacrylamide gel electrophoresis and shown to have an Mr of 100000 (Choe et al, 1978;Chu et al, 1978b;Lee et al, 1978).…”