Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover

Napoli, Nicola; Strollo, Rocky; Sprini, Delia; Maddaloni, Ernesto; Rini, Giovam Battista; Carmina, Enrico

doi:10.1155/2014/487463

Cited by 35 publications

(32 citation statements)

References 23 publications

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“…In postmenopausal women of southern Europe, BMD was lower in vitamin D-deficient groups who also had high levels of bone resorption and formation markers. 95 In 70 patients with CKD stage 5D, BMD was significantly low only at the mid-radius, but did not predict the risk of fracture and was not correlated with circulating 25OHD and 1,25OH2D levels. Rib fractures were associated with a poor nutritional status.…”

Section: Trabecular Bone Scorementioning

confidence: 80%

Fractures in patients with CKD—diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation

Pimentel

Ureña-Torres

Zillikens

et al. 2017

Kidney International

172

122

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Mineral and bone disease is omnipresent in patients with chronic kidney disease (CKD) and leads to a diverse range of clinical manifestations, including bone pain and fractures. The accumulation of traditional clinical risk factors, in addition to those related to CKD, enhances the risk of comorbidity and mortality. Despite significant advances in understanding bone disease in CKD, most clinical and biochemical targets used in clinical practice remain controversial, resulting in an undermanagement of bone fragility. Vitamin D supplementation is widely used, but only a few studies have shown beneficial effects and a reduced risk of fracture and mortality. The achievement of serum levels of 25-hydroxyvitamin D is recommended for CKD patients to reduce a high parathyroid hormone level, which is associated with skeletal fractures. Optimal control of parathyroid hormone also improves bone mineralization and lowers circulating bone biomarkers such as alkaline phosphatase and cross-linked collagen type I peptide. The potential value of more recent biomarkers such as sclerostin and fibroblast growth factor 23, as surrogates for bone fragility, is an encouraging new direction in clinical research but is far from being firmly established. This article reviews the literature related to the pathophysiological role of various mineral and biochemical factors involved in renal osteodystrophy. To better understand bone fragility in CKD, new information related to the impact of disturbances of mineral metabolism on bone strength is urgently needed. The combined expertise of clinicians from various medical disciplines appears crucial for the most successful prevention of fractures in these patients.Kidney International (2017) 92, 1343-1355; http://dx

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Section: Trabecular Bone Scorementioning

confidence: 80%

Fractures in patients with CKD—diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation

Pimentel

Ureña-Torres

Zillikens

et al. 2017

Kidney International

172

122

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“…Serum 25-OH-vitamin D b 30 ng/ml was defined as vitamin D deficiency [28]. Serum PTH was defined as elevated when N55 pg/ml [27].…”

Section: Serum Marker Measurementmentioning

confidence: 99%

Pediatric intestinal failure: Predictors of metabolic bone disease

Demehri¹,

Simha²,

Stephens³

et al. 2015

Journal of Pediatric Surgery

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“…There are reports of co-existence of vitamin D deficiency and low BMD among postmenopausal women of many countries of the world [8][9][10]. There is little information about vitamin D status and osteoporosis in Bangladeshi postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

Ahmed¹,

Haque²,

Uddin³

et al. 2019

IMC J Med Sci

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Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49

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Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover

Cited by 35 publications

References 23 publications

Fractures in patients with CKD—diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation

Fractures in patients with CKD—diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation

Pediatric intestinal failure: Predictors of metabolic bone disease

Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

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