Serum 25(OH)D response to vitamin D3 supplementation: A meta-regression analysis

Shab-Bidar, Sakineh; Bours, S.; Geusens, Piet; Kessels, Alfons G.H.; Bergh, Joop van den

doi:10.1016/j.nut.2013.12.020

Cited by 41 publications

(44 citation statements)

References 70 publications

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“…Most nutritionists recommend the use of vitamin D3 to treat and prevent vitamin D deficiency, because several studies indicating a higher efficacy for vitamin D3 in raising serum 25(OH)D concentrations when compared to vitamin D2 [96]. Although a significant inter-individual variation exists, due to different variables including body weight, sunlight exposure and calcium intake, it has been calculated that supplementation of 1000 IU of vitamin D3 daily leads to an approximate increase in 25(OH)D levels by 10–20 ng/mL (25–50 mmol/L), [97–99]. Findings from randomised placebo-controlled trials conducted during the winter have shown that each 1 mg of supplemental vitamin D is associated with an increase in serum 25(OH)D of between 0.7 nmol/L [100] and 2 nmol/L [75].…”

Section: The Nutritionist’s Point Of Viewmentioning

confidence: 99%

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Barrea

Savanelli

Somma

et al. 2017

Rev Endocr Metab Disord

184

179

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Psoriasis is a chronic immune-mediated inflammatory skin disease. Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. The epidermis is the natural source of vitamin D synthesis by sunlight action. Recently, a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis, has been reported. Indeed, significant associations between low vitamin D status and psoriasis have been systematically observed. Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. To date, the successful treatment based on adequate dietary intake of vitamin D or oral vitamin D supplementation in psoriasis represent an unmet clinical need and the evidence of its beneficial effects remains still controversial. This information is important either for Dermatologists and Nutritionists to increases the knowledge on the possible bi-directional relationships between low vitamin D status and psoriasis and on the potential usefulness of vitamin D in psoriasis with the aim not only to reduce its clinical severity, but also for delineating the risk profile for co-morbidities cardiac risk factors that may result from psoriasis. In the current review, we analyzed the possible bi-directional links between psoriatic disease and vitamin D.

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Section: The Nutritionist’s Point Of Viewmentioning

confidence: 99%

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Barrea

Savanelli

Somma

et al. 2017

Rev Endocr Metab Disord

184

179

View full text Add to dashboard Cite

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“…Most of the previous vitamin D studies that found age as non-modifying factor of the 25(OH)D response addressed only a specific age group [10,23]. A recently published meta-regression found age positively associated with the 25(OH)D 3 response [24]. The reason for the contradictory finding in the meta-regression and our study could be the mean age of the volunteers which were on average 66 years (subgroups: <69, 70e79 and >80 years) in the meta-regression study, and 39 years (subgroups: 29, 29e45 and >45 years) in the current study.…”

Section: Predictors Of Serum 25(oh)d 3 and 2425(oh) 2 D 3 Response Tmentioning

confidence: 99%

Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites – A randomized controlled trial

et al. 2016

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“…A rule of thumb is that supplementation of 1000 IU of vitamin D3 daily leads to an approximate increase in 25(OH)D levels by 10–20 ng/mL (25–50 mmol/L), but there exists a significant inter-individual variation. This dose-response relationship is also highly dependent on other factors including baseline 25(OH)D level, body weight, and concomitant calcium intake [107,108,109]. After initiation of vitamin D supplementation, re-measurement of 25(OH)D serum levels should not be performed before at least two to three consecutive months of treatment, since some time is needed for 25(OH)D levels to reach a steady state [108].…”

Section: Treatment Of Vitamin D Deficiencymentioning

confidence: 99%

Beneficial Effects of UV-Radiation: Vitamin D and beyond

Trummer

Pandis

Verheyen

et al. 2016

IJERPH

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Aside from its well-known effects on bone and mineral metabolism, vitamin D may also play an important role in extra-skeletal processes like immunologic diseases, cancer, or cardiovascular diseases. Even though meta-analyses showed that vitamin D supplementation reduces fractures, falls, and overall mortality, its potential benefits did not find universal acclaim. Several health care authorities published Recommended Dietary Allowances (RDAs) for vitamin D, most of them ranging from 600 to 800 international units (IU) per day, corresponding to a serum level of 25-hydroxyvitamin D of at least 20 ng/mL (50 nmol/L). However, studies conducted in the general population revealed a much lower overall intake of vitamin D than the proposed RDAs. Thus, strategies to increase the vitamin D intake in the general population, e.g., food fortification or vitamin D supplementation, are needed to match the existing evidence and recommendations. Therefore, several currently ongoing projects aim to investigate the effect of vitamin D supplementation in the general population and try to establish food-based solutions to improve vitamin D status.

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Serum 25(OH)D response to vitamin D3 supplementation: A meta-regression analysis

Cited by 41 publications

References 70 publications

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites – A randomized controlled trial

Beneficial Effects of UV-Radiation: Vitamin D and beyond

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